(44 nodes) Organelle membrane contact site network (Aspergillus welwitschiae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A3F3PHH6	Uncharacterized protein. (751 aa)
	A0A3F3PN03	Uncharacterized protein. (722 aa)
	A0A3F3QCE4	Uncharacterized protein. (280 aa)
	A0A3F3PLI4	Calcium/ hydrogen exchanger; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (1113 aa)
	A0A3F3PK76	Uncharacterized protein. (231 aa)
	A0A3F3PJS5	Uncharacterized protein. (252 aa)
	A0A3F3PJ33	Uncharacterized protein. (130 aa)
	A0A3F3PIR3	Uncharacterized protein. (314 aa)
	A0A3F3PIP8	Uncharacterized protein. (169 aa)
	A0A3F3PIL1	Uncharacterized protein. (341 aa)
	A0A3F3PID6	Uncharacterized protein. (173 aa)
	A0A3F3PI66	Uncharacterized protein. (599 aa)
	A0A3F3PHY0	Uncharacterized protein. (242 aa)
	A0A3F3PHM0	Uncharacterized protein. (769 aa)
	A0A3F3PN73	Small COPII coat GTPase SAR1; Belongs to the small GTPase superfamily. SAR1 family. (189 aa)
	A0A3F3PHE3	Uncharacterized protein. (541 aa)
	A0A3F3PH90	Uncharacterized protein. (241 aa)
	A0A3F3PH04	Uncharacterized protein. (183 aa)
	A0A3F3QBZ9	Uncharacterized protein. (472 aa)
	A0A3F3QBN2	MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (252 aa)
	A0A3F3QBJ4	Uncharacterized protein. (1222 aa)
	A0A3F3QA57	PKS_ER domain-containing protein. (346 aa)
	A0A3F3QHG6	MICOS complex subunit MIC10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (94 aa)
	A0A3F3Q7H2	GRAM domain protein. (1253 aa)
	A0A3F3Q5P3	Alpha/Beta hydrolase protein. (602 aa)
	A0A3F3Q5I6	PKD_channel domain-containing protein. (637 aa)
	A0A3F3Q4V4	Uncharacterized protein. (750 aa)
	A0A3F3Q4U9	Uncharacterized protein. (1061 aa)
	A0A3F3Q3Z6	Catalytic protein. (1438 aa)
	MDM34	Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. (563 aa)
	MDM12	Mitochondrial distribution and morphology protein 12; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pat [...] (435 aa)
	A0A3F3PZN9	Uncharacterized protein. (735 aa)
	A0A3F3PWR8	SMP-LTD domain-containing protein. (934 aa)
	A0A3F3PWP4	Uncharacterized protein. (472 aa)
	A0A3F3PV40	Uncharacterized protein. (713 aa)
	A0A3F3PUU5	WD40 repeat-like protein. (1536 aa)
	A0A3F3PR39	PXA domain-domain-containing protein. (1229 aa)
	A0A3F3QGP4	Uncharacterized protein. (1620 aa)
	A0A3F3QG95	Armadillo-type protein. (576 aa)
	MDM10	Mitochondrial distribution and morphology protein 10; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the recepto [...] (468 aa)
	A0A3F3QER5	Uncharacterized protein. (301 aa)
	MMM1	Maintenance of mitochondrial morphology protein 1; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta- barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 su [...] (485 aa)
	A0A3F3QCK9	Uncharacterized protein. (416 aa)
	A0A3F3PR05	MICOS complex subunit MIC12; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (123 aa)

Your Current Organism:

Aspergillus welwitschiae

NCBI taxonomy Id: 1341132
Other names: A. welwitschiae, Aspergillus welwitschiae (Bres.) Henn., CBS 139.54, Ustilago welwitschiae

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A3F3PH04	A0A3F3PHY0	A0A3F3PH04	A0A3F3PHY0	Uncharacterized protein.	Uncharacterized protein.	0.520
A0A3F3PH04	A0A3F3PV40	A0A3F3PH04	A0A3F3PV40	Uncharacterized protein.	Uncharacterized protein.	0.411
A0A3F3PH04	A0A3F3Q4V4	A0A3F3PH04	A0A3F3Q4V4	Uncharacterized protein.	Uncharacterized protein.	0.419
A0A3F3PH04	A0A3F3QBJ4	A0A3F3PH04	A0A3F3QBJ4	Uncharacterized protein.	Uncharacterized protein.	0.568
A0A3F3PH04	MDM10	A0A3F3PH04	A0A3F3QFL8	Uncharacterized protein.	Mitochondrial distribution and morphology protein 10; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the recepto [...]	0.700
A0A3F3PH04	MDM34	A0A3F3PH04	A0A3F3Q373	Uncharacterized protein.	Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.	0.532
A0A3F3PH04	MMM1	A0A3F3PH04	A0A3F3QDT0	Uncharacterized protein.	Maintenance of mitochondrial morphology protein 1; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta- barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 su [...]	0.719
A0A3F3PH90	A0A3F3PHE3	A0A3F3PH90	A0A3F3PHE3	Uncharacterized protein.	Uncharacterized protein.	0.411
A0A3F3PH90	A0A3F3PHY0	A0A3F3PH90	A0A3F3PHY0	Uncharacterized protein.	Uncharacterized protein.	0.562
A0A3F3PH90	A0A3F3QBJ4	A0A3F3PH90	A0A3F3QBJ4	Uncharacterized protein.	Uncharacterized protein.	0.568
A0A3F3PH90	MDM10	A0A3F3PH90	A0A3F3QFL8	Uncharacterized protein.	Mitochondrial distribution and morphology protein 10; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the recepto [...]	0.700
A0A3F3PH90	MDM34	A0A3F3PH90	A0A3F3Q373	Uncharacterized protein.	Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.	0.532
A0A3F3PH90	MMM1	A0A3F3PH90	A0A3F3QDT0	Uncharacterized protein.	Maintenance of mitochondrial morphology protein 1; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta- barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 su [...]	0.719
A0A3F3PHE3	A0A3F3PH90	A0A3F3PHE3	A0A3F3PH90	Uncharacterized protein.	Uncharacterized protein.	0.411
A0A3F3PHE3	A0A3F3QBJ4	A0A3F3PHE3	A0A3F3QBJ4	Uncharacterized protein.	Uncharacterized protein.	0.568
A0A3F3PHE3	MDM10	A0A3F3PHE3	A0A3F3QFL8	Uncharacterized protein.	Mitochondrial distribution and morphology protein 10; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the recepto [...]	0.762
A0A3F3PHE3	MDM34	A0A3F3PHE3	A0A3F3Q373	Uncharacterized protein.	Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.	0.629
A0A3F3PHE3	MMM1	A0A3F3PHE3	A0A3F3QDT0	Uncharacterized protein.	Maintenance of mitochondrial morphology protein 1; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta- barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 su [...]	0.765
A0A3F3PHH6	A0A3F3QBJ4	A0A3F3PHH6	A0A3F3QBJ4	Uncharacterized protein.	Uncharacterized protein.	0.568
A0A3F3PHH6	MDM10	A0A3F3PHH6	A0A3F3QFL8	Uncharacterized protein.	Mitochondrial distribution and morphology protein 10; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the recepto [...]	0.762