(33 nodes) Protein targeting to ER network (Aspergillus welwitschiae)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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gene co-occurrence

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co-expression

protein homology

Your Input:
	A0A3F3PSS4	Uncharacterized protein. (392 aa)
	A0A3F3PI99	TPR_REGION domain-containing protein. (261 aa)
	A0A3F3PJH7	Signal peptidase complex catalytic subunit SEC11. (170 aa)
	A0A3F3PLH0	Inorganic phosphate transport PHO88. (187 aa)
	A0A3F3PLV5	Bacterial luciferase-like protein. (428 aa)
	A0A3F3PMM3	Pre protein translocase subunit Sec66-domain-containing protein. (270 aa)
	A0A3F3PPI3	Signal recognition particle subunit SRP72; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane; Belongs to the SRP72 family. (652 aa)
	A0A3F3PQU8	TPR_REGION domain-containing protein. (341 aa)
	A0A3F3PR55	ICE2-domain-containing protein. (441 aa)
	A0A3F3PR85	SecY subunit domain-containing protein. (478 aa)
	A0A3F3PTH6	Signal peptidase complex component. (209 aa)
	A0A3F3PZ38	Translocation protein Sec62-domain-containing protein. (398 aa)
	A0A3F3PZN6	Uncharacterized protein. (202 aa)
	A0A3F3Q075	Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (533 aa)
	A0A3F3Q1T2	Signal recognition particle subunit SRP68; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane; Belongs to the SRP68 family. (613 aa)
	A0A3F3Q215	Signal peptidase subunit 3. (248 aa)
	A0A3F3Q223	Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (127 aa)
	A0A3F3Q2E4	Protein translocation complex component. (700 aa)
	A0A3F3Q2G7	Uncharacterized protein. (70 aa)
	GET3	ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...] (341 aa)
	A0A3F3Q4G0	ER membrane protein. (355 aa)
	A0A3F3Q7E2	Uncharacterized protein. (215 aa)
	A0A3F3Q804	Microsomal signal peptidase 12 kDa subunit-domain-containing protein. (143 aa)
	A0A3F3QA56	Signal recognition particle receptor beta subunit-domain-containing protein. (319 aa)
	A0A3F3QA80	78 kDa glucose-regulated protein; Belongs to the heat shock protein 70 family. (672 aa)
	A0A3F3QBD1	Uncharacterized protein. (189 aa)
	A0A3F3QCA6	Zn(2)-C6 fungal-type domain-containing protein. (1393 aa)
	A0A3F3QDR8	Signal recognition particle, alpha subunit, N-terminal-domain-containing protein. (646 aa)
	A0A3F3QDX4	Uncharacterized protein. (347 aa)
	A0A3F3QGD6	Uncharacterized protein. (389 aa)
	A0A3F3QGG9	Signal recognition particle 9 kDa protein-domain-containing protein. (166 aa)
	A0A3F3QH17	Uncharacterized protein. (461 aa)
	A0A3F3QJR7	Signal recognition particle, SRP14 subunit. (131 aa)

Your Current Organism:

Aspergillus welwitschiae

NCBI taxonomy Id: 1341132
Other names: A. welwitschiae, Aspergillus welwitschiae (Bres.) Henn., CBS 139.54, Ustilago welwitschiae

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A3F3PI99	A0A3F3PLV5	A0A3F3PI99	A0A3F3PLV5	TPR_REGION domain-containing protein.	Bacterial luciferase-like protein.	0.613
A0A3F3PI99	A0A3F3PZN6	A0A3F3PI99	A0A3F3PZN6	TPR_REGION domain-containing protein.	Uncharacterized protein.	0.632
A0A3F3PI99	A0A3F3Q223	A0A3F3PI99	A0A3F3Q223	TPR_REGION domain-containing protein.	Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum.	0.830
A0A3F3PI99	A0A3F3QA80	A0A3F3PI99	A0A3F3QA80	TPR_REGION domain-containing protein.	78 kDa glucose-regulated protein; Belongs to the heat shock protein 70 family.	0.440
A0A3F3PI99	A0A3F3QBD1	A0A3F3PI99	A0A3F3QBD1	TPR_REGION domain-containing protein.	Uncharacterized protein.	0.632
A0A3F3PI99	A0A3F3QDX4	A0A3F3PI99	A0A3F3QDX4	TPR_REGION domain-containing protein.	Uncharacterized protein.	0.869
A0A3F3PI99	GET3	A0A3F3PI99	A0A3F3Q3H7	TPR_REGION domain-containing protein.	ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...]	0.820
A0A3F3PJH7	A0A3F3PTH6	A0A3F3PJH7	A0A3F3PTH6	Signal peptidase complex catalytic subunit SEC11.	Signal peptidase complex component.	0.990
A0A3F3PJH7	A0A3F3Q215	A0A3F3PJH7	A0A3F3Q215	Signal peptidase complex catalytic subunit SEC11.	Signal peptidase subunit 3.	0.985
A0A3F3PJH7	A0A3F3Q223	A0A3F3PJH7	A0A3F3Q223	Signal peptidase complex catalytic subunit SEC11.	Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum.	0.528
A0A3F3PJH7	A0A3F3Q804	A0A3F3PJH7	A0A3F3Q804	Signal peptidase complex catalytic subunit SEC11.	Microsomal signal peptidase 12 kDa subunit-domain-containing protein.	0.986
A0A3F3PLV5	A0A3F3PI99	A0A3F3PLV5	A0A3F3PI99	Bacterial luciferase-like protein.	TPR_REGION domain-containing protein.	0.613
A0A3F3PLV5	A0A3F3PQU8	A0A3F3PLV5	A0A3F3PQU8	Bacterial luciferase-like protein.	TPR_REGION domain-containing protein.	0.613
A0A3F3PMM3	A0A3F3PR85	A0A3F3PMM3	A0A3F3PR85	Pre protein translocase subunit Sec66-domain-containing protein.	SecY subunit domain-containing protein.	0.983
A0A3F3PMM3	A0A3F3PSS4	A0A3F3PMM3	A0A3F3PSS4	Pre protein translocase subunit Sec66-domain-containing protein.	Uncharacterized protein.	0.856
A0A3F3PMM3	A0A3F3PTH6	A0A3F3PMM3	A0A3F3PTH6	Pre protein translocase subunit Sec66-domain-containing protein.	Signal peptidase complex component.	0.469
A0A3F3PMM3	A0A3F3PZ38	A0A3F3PMM3	A0A3F3PZ38	Pre protein translocase subunit Sec66-domain-containing protein.	Translocation protein Sec62-domain-containing protein.	0.975
A0A3F3PMM3	A0A3F3Q223	A0A3F3PMM3	A0A3F3Q223	Pre protein translocase subunit Sec66-domain-containing protein.	Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum.	0.923
A0A3F3PMM3	A0A3F3Q2E4	A0A3F3PMM3	A0A3F3Q2E4	Pre protein translocase subunit Sec66-domain-containing protein.	Protein translocation complex component.	0.983
A0A3F3PMM3	A0A3F3Q2G7	A0A3F3PMM3	A0A3F3Q2G7	Pre protein translocase subunit Sec66-domain-containing protein.	Uncharacterized protein.	0.974