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AGP53199.1 AGP53199.1 AGP53620.1 AGP53620.1 AGP53630.1 AGP53630.1 pyrF pyrF pyrD pyrD carB carB carA carA AGP53653.1 AGP53653.1 pyrC pyrC pyrB pyrB pyrR pyrR AGP55749.1 AGP55749.1 guaB guaB purM purM purF purF purL purL purQ purQ purS purS purC purC purD purD purA purA pyrE pyrE guaA guaA purN purN purH purH AGP57274.1 AGP57274.1 purK purK purE purE AGP59943.1 AGP59943.1 AGP61039.1 AGP61039.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGP53199.1Adenylosuccinate lyase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (477 aa)
AGP53620.1Nitrate reductase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (460 aa)
AGP53630.1Inosine 5'-monophosphate dehydrogenase; Catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (487 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the OMP decarboxylase family. Type 2 subfamily. (286 aa)
pyrDDiguanylate cyclase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (369 aa)
carBCarbamoyl phosphate synthase large subunit; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the CarB family. (1103 aa)
carACarbamoyl phosphate synthase small subunit; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the CarA family. (379 aa)
AGP53653.1Membrane protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (199 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (433 aa)
pyrBAspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (326 aa)
pyrRUracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. (193 aa)
AGP55749.1Inosine 5'-monophosphate dehydrogenase; Catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (375 aa)
guaBInosine-5`-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (500 aa)
purMPhosphoribosylaminoimidazole synthetase; Phage-associated protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (519 aa)
purLPhosphoribosylglycinamide synthetase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the tr [...] (749 aa)
purQPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (226 aa)
purSPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (94 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the SAICAR synthetase family. (306 aa)
purDPhosphoribosylamine--glycine ligase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the GARS family. (421 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (423 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (179 aa)
guaAGMP synthase; Catalyzes the synthesis of GMP from XMP. (528 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (218 aa)
purHIMP cyclohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (529 aa)
AGP57274.1Nucleoside triphosphate pyrophosphohydrolase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (344 aa)
purKPhosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (373 aa)
purEPhosphoribosylaminoimidazole carboxylase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (170 aa)
AGP59943.1Transporter; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (462 aa)
AGP61039.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (395 aa)
Your Current Organism:
Streptomyces rapamycinicus
NCBI taxonomy Id: 1343740
Other names: S. rapamycinicus NRRL 5491, Streptomyces rapamycinicus NRRL 5491
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