(31 nodes) Cysteine and methionine metabolism, and L-threonine ammonia-lyase activity network (Streptomyces rapamycinicus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AGP51696.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (743 aa)
	AGP51940.1	Cysteine synthase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (306 aa)
	glyA	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (438 aa)
	AGP51539.1	Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (475 aa)
	AGP52306.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (400 aa)
	AGP53284.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (407 aa)
	metK	S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (402 aa)
	mmuM	Converts homocysteine and S-adenosyl-methionine to methionine and S-adenosyl-homocysteine or S-methyl-methionine and homocysteine to two methionines; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (313 aa)
	AGP54801.1	3-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (533 aa)
	AGP54806.1	Dihydrofolate reductase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (308 aa)
	AGP54847.1	Serine dehydratase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the iron-sulfur dependent L-serine dehydratase family. (460 aa)
	thrB	Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (304 aa)
	AGP54996.1	Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (362 aa)
	AGP54997.1	Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (430 aa)
	AGP55381.1	Threonine dehydratase; Catalyzes the formation of 2-oxobutanoate from L-threonine; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (454 aa)
	AGP55385.1	Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (387 aa)
	AGP56558.1	Hydrolase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (210 aa)
	AGP56562.1	Cystathionine gamma-lyase; Catalyzes the formation of cysteine and 2-oxobutanoate from cystathionine; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (404 aa)
	serC	Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (372 aa)
	AGP51623.1	Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (461 aa)
	ahcY	S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (485 aa)
	AGP57626.1	Adenosylhomocysteinase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (373 aa)
	AGP58451.1	Pyridoxal-5'-phosphate-dependent protein subunit beta; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (380 aa)
	AGP58573.1	5,10-methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the methylenetetrahydrofolate reductase family. (290 aa)
	AGP58855.1	Phosphoserine phosphatase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (410 aa)
	AGP59087.1	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1167 aa)
	AGP59776.1	Serine/threonine dehydratase; Catalyzes the formation of 2-oxobutanoate from L-threonine or the formation of pyruvate from serine; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (337 aa)
	metE	5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (772 aa)
	AGP60003.1	Cysteine synthase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (382 aa)
	AGP60789.1	Threonine dehydratase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (295 aa)
	AGP61425.1	Threonine dehydratase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (310 aa)

Your Current Organism:

Streptomyces rapamycinicus

NCBI taxonomy Id: 1343740
Other names: S. rapamycinicus NRRL 5491, Streptomyces rapamycinicus NRRL 5491

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGP51539.1	AGP51623.1	M271_02840	M271_29250	Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.914
AGP51539.1	AGP51696.1	M271_02840	M271_00285	Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.485
AGP51539.1	AGP51940.1	M271_02840	M271_01515	Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Cysteine synthase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.849
AGP51539.1	AGP52306.1	M271_02840	M271_03380	Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.911
AGP51539.1	AGP53284.1	M271_02840	M271_08320	Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.911
AGP51539.1	AGP54801.1	M271_02840	M271_16170	Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	3-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.575
AGP51539.1	AGP54847.1	M271_02840	M271_16405	Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Serine dehydratase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the iron-sulfur dependent L-serine dehydratase family.	0.916
AGP51539.1	AGP54997.1	M271_02840	M271_17165	Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.881
AGP51539.1	AGP55381.1	M271_02840	M271_19160	Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Threonine dehydratase; Catalyzes the formation of 2-oxobutanoate from L-threonine; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.928
AGP51539.1	AGP55385.1	M271_02840	M271_19180	Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.996
AGP51539.1	AGP56558.1	M271_02840	M271_25355	Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hydrolase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.921
AGP51539.1	AGP56562.1	M271_02840	M271_25375	Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Cystathionine gamma-lyase; Catalyzes the formation of cysteine and 2-oxobutanoate from cystathionine; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.994
AGP51539.1	AGP57626.1	M271_02840	M271_30970	Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Adenosylhomocysteinase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.946
AGP51539.1	AGP58855.1	M271_02840	M271_37270	Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phosphoserine phosphatase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.943
AGP51539.1	AGP59087.1	M271_02840	M271_38475	Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.945
AGP51539.1	AGP59776.1	M271_02840	M271_42000	Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Serine/threonine dehydratase; Catalyzes the formation of 2-oxobutanoate from L-threonine or the formation of pyruvate from serine; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.939
AGP51539.1	AGP60003.1	M271_02840	M271_43150	Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Cysteine synthase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.827
AGP51539.1	AGP60789.1	M271_02840	M271_47130	Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Threonine dehydratase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.924
AGP51539.1	AGP61425.1	M271_02840	M271_50335	Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Threonine dehydratase; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.938
AGP51539.1	ahcY	M271_02840	M271_29550	Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.	0.949