STRINGSTRING
psuG psuG AGP52785.1 AGP52785.1 pyrF pyrF pyrD pyrD carB carB carA carA pyrC pyrC pyrB pyrB pyrR pyrR AGP53903.1 AGP53903.1 AGP54270.1 AGP54270.1 AGP54272.1 AGP54272.1 AGP54344.1 AGP54344.1 dut dut tdk tdk AGP54574.1 AGP54574.1 thyX thyX pyrH pyrH AGP55056.1 AGP55056.1 AGP55118.1 AGP55118.1 AGP55119.1 AGP55119.1 AGP55293.1 AGP55293.1 AGP55873.1 AGP55873.1 pyrE pyrE dcd dcd upp upp tmk tmk AGP56932.1 AGP56932.1 AGP57226.1 AGP57226.1 AGP57227.1 AGP57227.1 AGP57241.1 AGP57241.1 AGP57250.1 AGP57250.1 AGP57313.1 AGP57313.1 ndk ndk AGP58674.1 AGP58674.1 pyrG pyrG cmk cmk AGP60453.1 AGP60453.1 AGP60909.1 AGP60909.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
psuGPseudouridine-5'-phosphate glycosidase; Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway; Belongs to the pseudouridine-5'-phosphate glycosidase family. (311 aa)
AGP52785.1Carbohydrate kinase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (378 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the OMP decarboxylase family. Type 2 subfamily. (286 aa)
pyrDDiguanylate cyclase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (369 aa)
carBCarbamoyl phosphate synthase large subunit; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the CarB family. (1103 aa)
carACarbamoyl phosphate synthase small subunit; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the CarA family. (379 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (433 aa)
pyrBAspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (326 aa)
pyrRUracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant. (193 aa)
AGP53903.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (144 aa)
AGP54270.1Phenylhydantoinase; Catalyzes the hydrolytic cleavage of hydantoin with aromatic side chains at the 5'position; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (466 aa)
AGP54272.1Apolipoprotein acyltransferase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (280 aa)
AGP54344.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (250 aa)
dutHypothetical protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (171 aa)
tdkThymidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (214 aa)
AGP54574.1Vitamin B12-dependent ribonucleotide reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (955 aa)
thyXHypothetical protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (246 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (260 aa)
AGP55056.1Malonic semialdehyde reductase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (206 aa)
AGP55118.1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (807 aa)
AGP55119.1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (349 aa)
AGP55293.1Malonic semialdehyde reductase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (196 aa)
AGP55873.1Hydrolase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (426 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (179 aa)
dcddCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (191 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (211 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (1090 aa)
AGP56932.15'-nucleotidase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the 5'-nucleotidase family. (594 aa)
AGP57226.1Cytidine deaminase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (140 aa)
AGP57227.1Pyrimidine-nucleoside phosphorylase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (427 aa)
AGP57241.1ATP-binding protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (211 aa)
AGP57250.1Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (273 aa)
AGP57313.1Allantoate amidohydrolase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (408 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (137 aa)
AGP58674.1Nucleotidase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the 5'-nucleotidase family. (598 aa)
pyrGCTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (551 aa)
cmkCytidylate kinase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (234 aa)
AGP60453.1Malonic semialdehyde reductase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (209 aa)
AGP60909.1Amidase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (426 aa)
Your Current Organism:
Streptomyces rapamycinicus
NCBI taxonomy Id: 1343740
Other names: S. rapamycinicus NRRL 5491, Streptomyces rapamycinicus NRRL 5491
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