STRINGSTRING
hisC hisC aroQ aroQ AGP53444.1 AGP53444.1 aroB aroB aroK aroK aroC aroC AGP53665.1 AGP53665.1 AGP54299.1 AGP54299.1 aroA aroA AGP55867.1 AGP55867.1 pat pat AGP56598.1 AGP56598.1 AGP56999.1 AGP56999.1 AGP57116.1 AGP57116.1 trpD trpD AGP58557.1 AGP58557.1 hisC-2 hisC-2 priA-2 priA-2 trpE trpE trpC trpC trpB trpB trpA trpA AGP58665.1 AGP58665.1 AGP58795.1 AGP58795.1 AGP58897.1 AGP58897.1 AGP58898.1 AGP58898.1 AGP59003.1 AGP59003.1 rapK rapK AGP60042.1 AGP60042.1 AGP60770.1 AGP60770.1 aroA-2 aroA-2 AGP60999.1 AGP60999.1 AGP61037.1 AGP61037.1 AGP61369.1 AGP61369.1 AGP61380.1 AGP61380.1 AGP61436.1 AGP61436.1 aroQ-3 aroQ-3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hisCHypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (302 aa)
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (157 aa)
AGP53444.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (385 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (363 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (176 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (391 aa)
AGP53665.1Shikimate dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the shikimate dehydrogenase family. (275 aa)
AGP54299.1PheC; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (286 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (458 aa)
AGP55867.1Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (420 aa)
patAminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (359 aa)
AGP56598.1Prephenate dehydratase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (311 aa)
AGP56999.1Prephenate dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (369 aa)
AGP57116.1Chorismate mutase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (89 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (357 aa)
AGP58557.1Phospho-2-dehydro-3-deoxyheptonate aldolase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the class-II DAHP synthase family. (451 aa)
hisC-2Histidinol-phosphate aminotransferase; Catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (372 aa)
priA-21-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. (243 aa)
trpEAnthranilate synthase subunit I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrat [...] (496 aa)
trpCIndole-3-glycerol-phosphate synthase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the TrpC family. (269 aa)
trpBTryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (415 aa)
trpATryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (272 aa)
AGP58665.1Chorismate mutase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (129 aa)
AGP58795.1Aminotransferase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (371 aa)
AGP58897.1Chorismate mutase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (120 aa)
AGP58898.1Prephenate dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (361 aa)
AGP59003.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the class-II DAHP synthase family. (399 aa)
rapKHypothetical protein; Involved in the biosynthesis of the macrocyclic amino acid- linked polyketides rapamycin which is a potent immunosuppressant that prevents T-cell proliferation through initial binding to the immunophilin FKBP12. Catalyzes the hydrolysis of chorismate via a 1,4- conjugate elimination of water to yield (4R,5R)-4,5-dihydroxycyclohexa- 1,5-dienecarboxylic acid (DCDC); Belongs to the FkbO/Hyg5 family. (334 aa)
AGP60042.1Chorismate mutase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (213 aa)
AGP60770.1Histidinol phosphate aminotransferase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (339 aa)
aroA-2Hypothetical protein; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (451 aa)
AGP60999.1Aminotransferase class I/II; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (655 aa)
AGP61037.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (265 aa)
AGP61369.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the class-II DAHP synthase family. (391 aa)
AGP61380.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (330 aa)
AGP61436.1Shikimate dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the shikimate dehydrogenase family. (299 aa)
aroQ-33-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (151 aa)
Your Current Organism:
Streptomyces rapamycinicus
NCBI taxonomy Id: 1343740
Other names: S. rapamycinicus NRRL 5491, Streptomyces rapamycinicus NRRL 5491
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