STRINGSTRING
AGP51740.1 AGP51740.1 AGP51820.1 AGP51820.1 AGP51995.1 AGP51995.1 AGP51996.1 AGP51996.1 AGP51997.1 AGP51997.1 AGP51998.1 AGP51998.1 glyA glyA AGP52629.1 AGP52629.1 AGP52657.1 AGP52657.1 AGP52658.1 AGP52658.1 AGP52738.1 AGP52738.1 AGP52886.1 AGP52886.1 AGP52945.1 AGP52945.1 AGP52946.1 AGP52946.1 AGP52983.1 AGP52983.1 AGP53329.1 AGP53329.1 AGP53813.1 AGP53813.1 AGP53879.1 AGP53879.1 AGP53943.1 AGP53943.1 AGP53999.1 AGP53999.1 AGP54010.1 AGP54010.1 AGP54067.1 AGP54067.1 AGP54131.1 AGP54131.1 katE katE AGP54246.1 AGP54246.1 AGP54252.1 AGP54252.1 AGP54300.1 AGP54300.1 AGP54316.1 AGP54316.1 AGP54327.1 AGP54327.1 AGP54475.1 AGP54475.1 AGP54492.1 AGP54492.1 gcvT gcvT gcvH gcvH glyA-2 glyA-2 AGP54942.1 AGP54942.1 AGP54957.1 AGP54957.1 AGP54958.1 AGP54958.1 glyA-3 glyA-3 AGP55135.1 AGP55135.1 acsA acsA AGP57059.1 AGP57059.1 AGP57081.1 AGP57081.1 AGP57086.1 AGP57086.1 purU purU AGP57138.1 AGP57138.1 mdh mdh glyA-4 glyA-4 AGP57187.1 AGP57187.1 AGP57298.1 AGP57298.1 AGP57482.1 AGP57482.1 AGP57661.1 AGP57661.1 gltA gltA AGP58214.1 AGP58214.1 AGP58253.1 AGP58253.1 AGP58301.1 AGP58301.1 AGP58371.1 AGP58371.1 AGP58439.1 AGP58439.1 AGP58488.1 AGP58488.1 AGP58504.1 AGP58504.1 AGP59025.1 AGP59025.1 AGP59238.1 AGP59238.1 AGP59366.1 AGP59366.1 AGP59483.1 AGP59483.1 AGP59858.1 AGP59858.1 AGP59887.1 AGP59887.1 AGP59896.1 AGP59896.1 AGP59909.1 AGP59909.1 AGP60048.1 AGP60048.1 gcvP gcvP AGP60144.1 AGP60144.1 AGP60206.1 AGP60206.1 AGP60215.1 AGP60215.1 AGP60222.1 AGP60222.1 AGP60391.1 AGP60391.1 AGP60541.1 AGP60541.1 AGP60623.1 AGP60623.1 AGP61069.1 AGP61069.1 AGP61192.1 AGP61192.1 AGP61193.1 AGP61193.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AGP51740.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the thiolase-like superfamily. Thiolase family. (387 aa)
AGP51820.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (385 aa)
AGP51995.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the glycerate kinase type-1 family. (370 aa)
AGP51996.1Glyoxylate carboligase; Catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the TPP enzyme family. (589 aa)
AGP51997.1Tartronate semialdehyde reductase; NADH-dependent; catalyzed the reversible formation of glycerate from tartronate semialdehyde; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (298 aa)
AGP51998.1Hydroxypyruvate isomerase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the hyi family. (276 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (438 aa)
AGP52629.1Dihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (466 aa)
AGP52657.1Formate dehydrogenase subunit alpha; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1087 aa)
AGP52658.1Ferredoxin; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (342 aa)
AGP52738.1AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (537 aa)
AGP52886.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the thiolase-like superfamily. Thiolase family. (385 aa)
AGP52945.1methylmalonyl-CoA mutase; MDM; functions in conversion of succinate to propionate; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (737 aa)
AGP52946.1methylmalonyl-CoA mutase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (590 aa)
AGP52983.1Glutamine synthetase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the glutamine synthetase family. (452 aa)
AGP53329.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the thiolase-like superfamily. Thiolase family. (382 aa)
AGP53813.1Glutamate--ammonia ligase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the glutamine synthetase family. (455 aa)
AGP53879.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the thiolase-like superfamily. Thiolase family. (404 aa)
AGP53943.1Haloacid dehalogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (224 aa)
AGP53999.1acetyl-CoA synthetase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (568 aa)
AGP54010.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (137 aa)
AGP54067.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the thiolase-like superfamily. Thiolase family. (402 aa)
AGP54131.1Formate dehydrogenase subunit alpha; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (649 aa)
katEHydroperoxidase II; Serves to protect cells from the toxic effects of hydrogen peroxide. (699 aa)
AGP54246.1Protein meaA; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (659 aa)
AGP54252.1Glycerate kinase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the glycerate kinase type-1 family. (377 aa)
AGP54300.12-dehydro-3-deoxyphosphogluconate aldolase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (217 aa)
AGP54316.1Malate synthase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the malate synthase family. (539 aa)
AGP54327.1AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (565 aa)
AGP54475.1Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (913 aa)
AGP54492.1Aldolase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (210 aa)
gcvTGlycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. (375 aa)
gcvHGlycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa)
glyA-2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (426 aa)
AGP54942.1methylmalonyl-CoA mutase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (532 aa)
AGP54957.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa)
AGP54958.1methylmalonyl-CoA epimerase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (150 aa)
glyA-3Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (429 aa)
AGP55135.1Catalase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the catalase family. (488 aa)
acsAacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (667 aa)
AGP57059.1Haloacid dehalogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (213 aa)
AGP57081.1acetyl-CoA carboxylase subunit alpha; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (670 aa)
AGP57086.1Forms citrate from oxaloacetate and acetyl-CoA; functions in TCA cycle; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the citrate synthase family. (367 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (289 aa)
AGP57138.1methylmalonyl-CoA mutase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (136 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
glyA-4Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (423 aa)
AGP57187.1methylmalonyl-CoA mutase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (529 aa)
AGP57298.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa)
AGP57482.1FAD-linked oxidase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (455 aa)
AGP57661.1Biotin carboxyl carrier protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (730 aa)
gltAType II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the citrate synthase family. (429 aa)
AGP58214.1acetyl-CoA acetyltransferase; Catalyzes the thiolytic cleavage of beta-ketoadipyl-CoA to succinate and acetyl-CoA; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the thiolase-like superfamily. Thiolase family. (389 aa)
AGP58253.1Ketohydroxyglutarate aldolase; Catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (216 aa)
AGP58301.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (249 aa)
AGP58371.1Tartrate dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (358 aa)
AGP58439.1Glutamine synthetase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the glutamine synthetase family. (453 aa)
AGP58488.1Glutamine synthetase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (469 aa)
AGP58504.1Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (462 aa)
AGP59025.1Formate dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (204 aa)
AGP59238.1Ketohydroxyglutarate aldolase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (213 aa)
AGP59366.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the hyi family. (263 aa)
AGP59483.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (615 aa)
AGP59858.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (214 aa)
AGP59887.1Haloacid dehalogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (234 aa)
AGP59896.1L-glutamine synthetase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the glutamine synthetase family. (451 aa)
AGP59909.1Aconitate hydratase; Catalyzes the conversion of citrate to isocitrate; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (659 aa)
AGP60048.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (388 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (971 aa)
AGP60144.1crotonyl-CoA reductase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (415 aa)
AGP60206.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa)
AGP60215.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the thiolase-like superfamily. Thiolase family. (385 aa)
AGP60222.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the thiolase-like superfamily. Thiolase family. (356 aa)
AGP60391.1FAD-linked oxidase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (457 aa)
AGP60541.1Hydroxypyruvate isomerase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the hyi family. (260 aa)
AGP60623.1Cyclase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (214 aa)
AGP61069.1Tartrate dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (360 aa)
AGP61192.1methylmalonyl-CoA carboxyltransferase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (529 aa)
AGP61193.1Biotin carboxyl carrier protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (590 aa)
Your Current Organism:
Streptomyces rapamycinicus
NCBI taxonomy Id: 1343740
Other names: S. rapamycinicus NRRL 5491, Streptomyces rapamycinicus NRRL 5491
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.