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| | AGP51698.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (496 aa) |
| | hisC | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (302 aa) |
| | AGP51843.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the IlvD/Edd family. (564 aa) |
| | AGP51933.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (396 aa) |
| | AGP51940.1 | Cysteine synthase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (306 aa) |
| | AGP51984.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (368 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (438 aa) |
| | AGP52144.1 | Asparagine synthase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (608 aa) |
| | AGP52170.1 | 2-hydroxyacid dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (317 aa) |
| | AGP51539.1 | Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (475 aa) |
| | AGP52285.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (391 aa) |
| | AGP52306.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (400 aa) |
| | AGP52503.1 | Glyceraldehyde-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (484 aa) |
| | AGP52504.1 | Asparagine synthase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (613 aa) |
| | gltD | Glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (501 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (157 aa) |
| | AGP52860.1 | Fructose-bisphosphate aldolase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (279 aa) |
| | AGP52903.1 | Transketolase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (611 aa) |
| | AGP52983.1 | Glutamine synthetase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the glutamine synthetase family. (452 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (341 aa) |
| | AGP53284.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (407 aa) |
| | AGP53291.1 | Dihydroxy-acid dehydratase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the IlvD/Edd family. (551 aa) |
| | AGP53357.1 | Ribose 5-phosphate isomerase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (156 aa) |
| | AGP53444.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (385 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (282 aa) |
| | hisE | phosphoribosyl-ATP pyrophosphatase; Catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (94 aa) |
| | AGP53637.1 | Ribulose-phosphate 3-epimerase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the ribulose-phosphate 3-epimerase family. (224 aa) |
| | metK | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (402 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (363 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (176 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (391 aa) |
| | AGP53665.1 | Shikimate dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the shikimate dehydrogenase family. (275 aa) |
| | AGP53715.1 | Class IV aminotransferase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (275 aa) |
| | argH | Argininosuccinate lyase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (476 aa) |
| | argG | Argininosuccinate synthase; Catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (398 aa) |
| | argD | Acetylornithine aminotransferase; Catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (400 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (316 aa) |
| | argJ | N-acetylglutamate synthase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (384 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (342 aa) |
| | AGP53763.1 | Isocitrate dehydrogenase; NADP-specific, catalyzes the formation of 2-oxoglutarate from isocitrate or oxalosuccinate; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the monomeric-type IDH family. (739 aa) |
| | AGP53779.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (581 aa) |
| | AGP53813.1 | Glutamate--ammonia ligase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the glutamine synthetase family. (455 aa) |
| | AGP53882.1 | Glucose dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the DapA family. (312 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (451 aa) |
| | AGP53935.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the TPP enzyme family. (571 aa) |
| | AGP53941.1 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (682 aa) |
| | AGP54078.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the TPP enzyme family. (540 aa) |
| | AGP54090.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (397 aa) |
| | AGP54106.1 | Acetolactate synthase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the TPP enzyme family. (571 aa) |
| | AGP54299.1 | PheC; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (286 aa) |
| | AGP54348.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (159 aa) |
| | AGP54475.1 | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (913 aa) |
| | AGP54496.1 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (334 aa) |
| | AGP54579.1 | 2,4-diaminobutyrate 4-aminotransferase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (574 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (310 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (299 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (250 aa) |
| | AGP54701.1 | Acetolactate synthase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the TPP enzyme family. (562 aa) |
| | leuD | Isopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (197 aa) |
| | leuC | Isopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (476 aa) |
| | AGP54788.1 | Transferase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the alpha-IPM synthase/homocitrate synthase family. (532 aa) |
| | AGP54789.1 | Catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (361 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (339 aa) |
| | AGP54801.1 | 3-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (533 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (332 aa) |
| | AGP54803.1 | Acetolactate synthase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (174 aa) |
| | AGP54804.1 | Acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (617 aa) |
| | glyA-2 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (426 aa) |
| | AGP54847.1 | Serine dehydratase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the iron-sulfur dependent L-serine dehydratase family. (460 aa) |
| | pfkA-2 | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (341 aa) |
| | AGP54936.1 | Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (475 aa) |
| | glyA-3 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (429 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (304 aa) |
| | AGP54996.1 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (362 aa) |
| | AGP54997.1 | Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (430 aa) |
| | lysA-2 | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (466 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (458 aa) |
| | AGP55133.1 | Histidinol-phosphatase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (264 aa) |
| | AGP55202.1 | Succinyl-diaminopimelate desuccinylase; Catalyzes the formation of succinate and diaminoheptanedioate from succinyldiaminoheptanedioate; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (356 aa) |
| | AGP55207.1 | Acetyltransferase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (338 aa) |
| | AGP55272.1 | Acetolactate synthase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the TPP enzyme family. (595 aa) |
| | AGP55364.1 | Aminotransferase AlaT; Broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (403 aa) |
| | AGP55381.1 | Threonine dehydratase; Catalyzes the formation of 2-oxobutanoate from L-threonine; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (454 aa) |
| | AGP55385.1 | Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (387 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (325 aa) |
| | AGP55867.1 | Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (420 aa) |
| | AGP56003.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the IlvD/Edd family. (547 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (269 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the IlvD/Edd family. (602 aa) |
| | AGP56265.1 | Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (340 aa) |
| | AGP56280.1 | Aminotransferase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (393 aa) |
| | AGP56357.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (259 aa) |
| | AGP56358.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (484 aa) |
| | AGP56558.1 | Hydrolase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (210 aa) |
| | AGP56562.1 | Cystathionine gamma-lyase; Catalyzes the formation of cysteine and 2-oxobutanoate from cystathionine; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (404 aa) |
| | pat | Aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (359 aa) |
| | AGP56598.1 | Prephenate dehydratase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (311 aa) |
| | pfp | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (341 aa) |
| | AGP56741.1 | Aspartokinase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the aspartokinase family. (426 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (363 aa) |
| | AGP56921.1 | N-acetylglutamate synthase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the acetyltransferase family. (152 aa) |
| | gpmA | Phosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (253 aa) |
| | AGP56999.1 | Prephenate dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (369 aa) |
| | AGP57033.1 | Threonine synthase; Catalyzes the formation of L-threonine from O-phospho-L-homoserine; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (407 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (372 aa) |
| | AGP57086.1 | Forms citrate from oxaloacetate and acetyl-CoA; functions in TCA cycle; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the citrate synthase family. (367 aa) |
| | AGP57116.1 | Chorismate mutase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (89 aa) |
| | glyA-4 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (423 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (426 aa) |
| | AGP51623.1 | Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (461 aa) |
| | AGP57310.1 | Diaminopimelate decarboxylase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (444 aa) |
| | gltA | Type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the citrate synthase family. (429 aa) |
| | asd-2 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (341 aa) |
| | AGP57844.1 | Catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (162 aa) |
| | proB | Gamma-glutamyl kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (400 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (432 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (594 aa) |
| | AGP58439.1 | Glutamine synthetase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the glutamine synthetase family. (453 aa) |
| | AGP58451.1 | Pyridoxal-5'-phosphate-dependent protein subunit beta; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (380 aa) |
| | AGP58488.1 | Glutamine synthetase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (469 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (357 aa) |
| | pfp-2 | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (342 aa) |
| | AGP58557.1 | Phospho-2-dehydro-3-deoxyheptonate aldolase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the class-II DAHP synthase family. (451 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (441 aa) |
| | hisC-2 | Histidinol-phosphate aminotransferase; Catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (372 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (197 aa) |
| | hisH | Imidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (212 aa) |
| | priA-2 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. (243 aa) |
| | hisF | Imidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (256 aa) |
| | trpE | Anthranilate synthase subunit I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrat [...] (496 aa) |
| | trpC | Indole-3-glycerol-phosphate synthase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the TrpC family. (269 aa) |
| | trpB | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (415 aa) |
| | trpA | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (272 aa) |
| | AGP58655.1 | Glutamate synthase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (1505 aa) |
| | gltD-2 | Glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (486 aa) |
| | AGP58665.1 | Chorismate mutase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (129 aa) |
| | AGP58676.1 | Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (467 aa) |
| | gapA | Glyceraldehyde-3-phosphate dehydrogenase; Required for glycolysis; catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (334 aa) |
| | pgk | Phosphoglycerate kinase; Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the phosphoglycerate kinase family. (400 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (372 aa) |
| | AGP58735.1 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (692 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (329 aa) |
| | AGP58771.1 | Dihydrodipicolinate synthase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the DapA family. (300 aa) |
| | AGP58789.1 | Diadenosine tetraphosphatase; Catalyzes reversively the conversion of L-aspartate beta- semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (420 aa) |
| | AGP58795.1 | Aminotransferase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (371 aa) |
| | AGP58855.1 | Phosphoserine phosphatase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (410 aa) |
| | AGP58897.1 | Chorismate mutase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (120 aa) |
| | AGP58898.1 | Prephenate dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (361 aa) |
| | AGP58949.1 | Diaminopimelate decarboxylase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (410 aa) |
| | AGP59003.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the class-II DAHP synthase family. (399 aa) |
| | AGP59087.1 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1167 aa) |
| | AGP59123.1 | Transketolase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (300 aa) |
| | AGP59124.1 | Transketolase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (233 aa) |
| | AGP59131.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (501 aa) |
| | AGP59146.1 | Inositol monophosphatase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (281 aa) |
| | AGP59159.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the DapA family. (314 aa) |
| | dapA-2 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (304 aa) |
| | AGP59435.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the DapA family. (296 aa) |
| | AGP59550.1 | Asparagine synthase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (638 aa) |
| | AGP59710.1 | 2-hydroxyacid dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (356 aa) |
| | AGP59713.1 | Ribose 5-phosphate isomerase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (154 aa) |
| | AGP59776.1 | Serine/threonine dehydratase; Catalyzes the formation of 2-oxobutanoate from L-threonine or the formation of pyruvate from serine; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (337 aa) |
| | AGP59850.1 | Transketolase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (286 aa) |
| | AGP59851.1 | Transketolase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (328 aa) |
| | AGP59865.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (312 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (772 aa) |
| | AGP59896.1 | L-glutamine synthetase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the glutamine synthetase family. (451 aa) |
| | AGP59909.1 | Aconitate hydratase; Catalyzes the conversion of citrate to isocitrate; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (659 aa) |
| | AGP59970.1 | Threonine aldolase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (353 aa) |
| | AGP60003.1 | Cysteine synthase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (382 aa) |
| | AGP60042.1 | Chorismate mutase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (213 aa) |
| | AGP60170.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (413 aa) |
| | argG-2 | Argininosuccinate synthase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (482 aa) |
| | AGP60712.1 | Succinyl-diaminopimelate desuccinylase; Catalyzes the formation of succinate and diaminoheptanedioate from succinyldiaminoheptanedioate; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (368 aa) |
| | AGP60755.1 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1125 aa) |
| | AGP60770.1 | Histidinol phosphate aminotransferase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (339 aa) |
| | AGP60789.1 | Threonine dehydratase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (295 aa) |
| | aroA-2 | Hypothetical protein; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (451 aa) |
| | gapA-2 | Glyceraldehyde-3-phosphate dehydrogenase; Required for glycolysis; catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (332 aa) |
| | AGP60999.1 | Aminotransferase class I/II; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (655 aa) |
| | AGP61037.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (265 aa) |
| | AGP61079.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (170 aa) |
| | AGP61369.1 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the class-II DAHP synthase family. (391 aa) |
| | AGP61425.1 | Threonine dehydratase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (310 aa) |
| | AGP61436.1 | Shikimate dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the shikimate dehydrogenase family. (299 aa) |
| | aroQ-3 | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (151 aa) |
