STRINGSTRING
tilS tilS hpt hpt APD31021.1 APD31021.1 adk adk purA purA APD31188.1 APD31188.1 APD31194.1 APD31194.1 APD31215.1 APD31215.1 cpdB cpdB APD32827.1 APD32827.1 pyrD pyrD APD31511.1 APD31511.1 APD31512.1 APD31512.1 APD31513.1 APD31513.1 udk udk apt apt APD31668.1 APD31668.1 APD31669.1 APD31669.1 deoB deoB arsC arsC APD31677.1 APD31677.1 deoD deoD hk hk pyrF pyrF pyrE pyrE APD31705.1 APD31705.1 glmS glmS coaA coaA APD31764.1 APD31764.1 deoA deoA deoC deoC APD31767.1 APD31767.1 APD31768.1 APD31768.1 APD31769.1 APD31769.1 APD31770.1 APD31770.1 satA satA APD31782.1 APD31782.1 guaA guaA BMF34_05060 BMF34_05060 xpt xpt guaC guaC APD31950.1 APD31950.1 pyrR pyrR APD31959.1 APD31959.1 APD32048.1 APD32048.1 add add APD32099.1 APD32099.1 APD32230.1 APD32230.1 APD32231.1 APD32231.1 APD32232.1 APD32232.1 glmU glmU APD32234.1 APD32234.1 APD32235.1 APD32235.1 APD32236.1 APD32236.1 APD32237.1 APD32237.1 upp upp gmk gmk luxS luxS nadE nadE APD32377.1 APD32377.1 APD32378.1 APD32378.1 APD32379.1 APD32379.1 APD32473.1 APD32473.1 APD32601.1 APD32601.1 nrdG nrdG APD32748.1 APD32748.1 APD32749.1 APD32749.1 APD32750.1 APD32750.1 guaB guaB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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tilStRNA lysidine(34) synthetase TilS; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. (395 aa)
hptHypoxanthine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (180 aa)
APD31021.1Adenylosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (430 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (212 aa)
purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa)
APD31188.1Phosphoribulokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (198 aa)
APD31194.1DNA topology modulation protein FlaR; Derived by automated computational analysis using gene prediction method: Protein Homology. (168 aa)
APD31215.1Ribonucleotide reductase assembly protein NrdI; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NrdI family. (154 aa)
cpdB2',3'-cyclic-nucleotide 2'-phosphodiesterase; In Escherichia coli this is a periplasmic enzyme while in gram positive organisms it may be anchored at the cell surface; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (795 aa)
APD32827.1Haloacid dehalogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (215 aa)
pyrDDihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate. (311 aa)
APD31511.1Class 1b ribonucleoside-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (319 aa)
APD31512.1Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (719 aa)
APD31513.1NrdH-redoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (72 aa)
udkUridine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (208 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (172 aa)
APD31668.1Noncanonical pyrimidine nucleotidase, YjjG family; Derived by automated computational analysis using gene prediction method: Protein Homology. (229 aa)
APD31669.1Succinate-semialdehyde dehydrogenase; In Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (457 aa)
deoBPhosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (403 aa)
arsCArsenate reductase (glutaredoxin); Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ArsC family. (135 aa)
APD31677.1Purine-nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (269 aa)
deoDPurine-nucleoside phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (237 aa)
hkLytR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (261 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (243 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (208 aa)
APD31705.1Dihydroorotase; Derived by automated computational analysis using gene prediction method: Protein Homology. (156 aa)
glmSGlutamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (604 aa)
coaAType I pantothenate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (306 aa)
APD31764.1Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (199 aa)
deoAPyrimidine-nucleoside phosphorylase; Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (425 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (220 aa)
APD31767.1Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (129 aa)
APD31768.1BMP family ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (351 aa)
APD31769.1Heme ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (510 aa)
APD31770.1Branched-chain amino acid ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the binding-protein-dependent transport system permease family. (354 aa)
satASugar ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the binding-protein-dependent transport system permease family. (318 aa)
APD31782.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (112 aa)
guaAGlutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP. (520 aa)
BMF34_05060Transposase; Frameshifted; internal stop; Derived by automated computational analysis using gene prediction method: Protein Homology. (422 aa)
xptXanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (193 aa)
guaCGMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. (327 aa)
APD31950.1Uracil permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (419 aa)
pyrRBifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. (173 aa)
APD31959.1Ribonucleoside hydrolase RihC; Derived by automated computational analysis using gene prediction method: Protein Homology. (303 aa)
APD32048.1Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (226 aa)
addAdenosine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (339 aa)
APD32099.1HAD family hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (300 aa)
APD32230.15'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (230 aa)
APD32231.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (86 aa)
APD32232.1ADP-ribose pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (183 aa)
glmUUDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (461 aa)
APD32234.1NAD(P)-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (321 aa)
APD32235.13-oxoacyl-ACP reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (232 aa)
APD32236.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (78 aa)
APD32237.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (81 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (208 aa)
luxSS-ribosylhomocysteine lyase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (160 aa)
nadENAD(+) synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (274 aa)
APD32377.1Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (486 aa)
APD32378.1IS30 family transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (317 aa)
APD32379.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (114 aa)
APD32473.1Isochorismatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (182 aa)
APD32601.1Pur operon repressor; Derived by automated computational analysis using gene prediction method: Protein Homology. (270 aa)
nrdGAnaerobic ribonucleoside-triphosphate reductase activating protein; Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine. (206 aa)
APD32748.1GNAT family N-acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (166 aa)
APD32749.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (310 aa)
APD32750.1Anaerobic ribonucleoside-triphosphate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (731 aa)
guaBIMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (493 aa)
Your Current Organism:
Streptococcus iniae
NCBI taxonomy Id: 1346
Other names: ATCC 29178, CCUG 27303, CIP 102508, DSM 20576, LMG 14520, LMG:14520, S. iniae, Streptococcus shiloi, strain PW
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