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queA queA mnmE mnmE APD31863.1 APD31863.1 nadK nadK APD31865.1 APD31865.1 APD31866.1 APD31866.1 prs-2 prs-2 APD31868.1 APD31868.1 APD31869.1 APD31869.1 APD31870.1 APD31870.1 rex rex APD31872.1 APD31872.1 BMF34_05630 BMF34_05630 thiI thiI APD31965.1 APD31965.1 APD31966.1 APD31966.1 APD32028.1 APD32028.1 rsmG rsmG tgt tgt APD32789.1 APD32789.1 APD32792.1 APD32792.1 mnmG mnmG APD32794.1 APD32794.1 mnmA mnmA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
queAtRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (342 aa)
mnmEtRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. (458 aa)
APD31863.1RNA pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (297 aa)
nadKNAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (278 aa)
APD31865.1GTP pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (223 aa)
APD31866.1Adenylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (190 aa)
prs-2Ribose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (323 aa)
APD31868.1Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology. (371 aa)
APD31869.1Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology. (115 aa)
APD31870.1DUF4649 domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (70 aa)
rexRedox-sensing transcriptional repressor Rex; Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. (214 aa)
APD31872.1Gamma-glutamyl hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (233 aa)
BMF34_05630Hypothetical protein; Incomplete; partial on complete genome; missing start; Derived by automated computational analysis using gene prediction method: Protein Homology. (398 aa)
thiItRNA 4-thiouridine(8) synthase ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (404 aa)
APD31965.1Derived by automated computational analysis using gene prediction method: Protein Homology. (380 aa)
APD31966.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (139 aa)
APD32028.1Queuosine transporter QueT; Derived by automated computational analysis using gene prediction method: Protein Homology. (168 aa)
rsmG16S rRNA (guanine(527)-N(7))-methyltransferase RsmG; Specifically methylates the N7 position of a guanine in 16S rRNA; Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family. (238 aa)
tgttRNA guanosine(34) transglycosylase Tgt; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose t [...] (380 aa)
APD32789.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (92 aa)
APD32792.1DHH family phosphoesterase; Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP); Belongs to the GdpP/PdeA phosphodiesterase family. (657 aa)
mnmGtRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG; NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34; Belongs to the MnmG family. (632 aa)
APD32794.1Phosphohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (152 aa)
mnmAtRNA 2-thiouridine(34) synthase MnmA; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (373 aa)
Your Current Organism:
Streptococcus iniae
NCBI taxonomy Id: 1346
Other names: ATCC 29178, CCUG 27303, CIP 102508, DSM 20576, LMG 14520, LMG:14520, S. iniae, Streptococcus shiloi, strain PW
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