(10 nodes) Serine family amino acid metabolic process network (Streptococcus iniae)

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Your Input:
	cysE	Serine O-acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (194 aa)
	APD31913.1	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (165 aa)
	glyA	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
	serB	Phosphoserine phosphatase SerB; Derived by automated computational analysis using gene prediction method: Protein Homology. (218 aa)
	APD31330.1	Cysteine desulfurase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. (408 aa)
	APD32258.1	Phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (391 aa)
	APD32711.1	Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (379 aa)
	serS	serine--tRNA ligase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (425 aa)
	cysK	Cysteine synthase A; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family. (308 aa)
	serC	Phosphoserine transaminase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (363 aa)

Your Current Organism:

Streptococcus iniae

NCBI taxonomy Id: 1346
Other names: ATCC 29178, CCUG 27303, CIP 102508, DSM 20576, LMG 14520, LMG:14520, S. iniae, Streptococcus shiloi, strain PW

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APD31330.1	APD32711.1	BMF34_02200	BMF34_09610	Cysteine desulfurase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.	Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.534
APD31330.1	glyA	BMF34_02200	BMF34_04995	Cysteine desulfurase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.620
APD31913.1	glyA	BMF34_05360	BMF34_04995	Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.629
APD32258.1	APD32711.1	BMF34_07165	BMF34_09610	Phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.421
APD32258.1	cysK	BMF34_07165	BMF34_07730	Phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Cysteine synthase A; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family.	0.707
APD32258.1	glyA	BMF34_07165	BMF34_04995	Phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.462
APD32258.1	serB	BMF34_07165	BMF34_06040	Phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Phosphoserine phosphatase SerB; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.710
APD32258.1	serC	BMF34_07165	BMF34_07175	Phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Phosphoserine transaminase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine.	0.997
APD32711.1	APD31330.1	BMF34_09610	BMF34_02200	Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Cysteine desulfurase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.	0.534
APD32711.1	APD32258.1	BMF34_09610	BMF34_07165	Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.421
APD32711.1	cysE	BMF34_09610	BMF34_01705	Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Serine O-acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.746
APD32711.1	cysK	BMF34_09610	BMF34_07730	Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Cysteine synthase A; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family.	0.919
APD32711.1	glyA	BMF34_09610	BMF34_04995	Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.611
APD32711.1	serB	BMF34_09610	BMF34_06040	Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phosphoserine phosphatase SerB; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.650
cysE	APD32711.1	BMF34_01705	BMF34_09610	Serine O-acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.746
cysE	cysK	BMF34_01705	BMF34_07730	Serine O-acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Cysteine synthase A; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family.	0.986
cysE	glyA	BMF34_01705	BMF34_04995	Serine O-acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.620
cysE	serB	BMF34_01705	BMF34_06040	Serine O-acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phosphoserine phosphatase SerB; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.645
cysE	serC	BMF34_01705	BMF34_07175	Serine O-acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phosphoserine transaminase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine.	0.542
cysK	APD32258.1	BMF34_07730	BMF34_07165	Cysteine synthase A; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family.	Phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.707