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purA purA guaB guaB cinA cinA APD32654.1 APD32654.1 accC accC accD accD accA accA APD32377.1 APD32377.1 nadE nadE gmk gmk nadD nadD APD32343.1 APD32343.1 upp upp tmk tmk pyrH pyrH coaE coaE APD32021.1 APD32021.1 atpB atpB atpF atpF atpH atpH atpA atpA atpG atpG atpD atpD atpC atpC cmk cmk thyA thyA prs-2 prs-2 APD31865.1 APD31865.1 nadK nadK xpt xpt tdk tdk guaA guaA APD31782.1 APD31782.1 APD31777.1 APD31777.1 coaC coaC coaA coaA APD31750.1 APD31750.1 APD31705.1 APD31705.1 pyrE pyrE pyrF pyrF APD31658.1 APD31658.1 dacA dacA APD31640.1 APD31640.1 APD31638.1 APD31638.1 apt apt udk udk APD31511.1 APD31511.1 pyrD pyrD folD folD APD31447.1 APD31447.1 coaD coaD pyrG pyrG APD31217.1 APD31217.1 APD31194.1 APD31194.1 APD31188.1 APD31188.1 APD31120.1 APD31120.1 ackA ackA adk adk APD31021.1 APD31021.1 prs prs hpt hpt
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa)
guaBIMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (493 aa)
cinACompetence/damage-inducible protein A; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CinA family. (423 aa)
APD32654.1Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (147 aa)
accCacetyl-CoA carboxylase biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (454 aa)
accDacetyl-CoA carboxylase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (288 aa)
accAacetyl-CoA carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (256 aa)
APD32377.1Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (486 aa)
nadENAD(+) synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (274 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (208 aa)
nadDNicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (210 aa)
APD32343.1HD domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (197 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa)
tmkdTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (210 aa)
pyrHUMP kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (244 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (203 aa)
APD32021.1F0F1 ATP synthase subunit C; Derived by automated computational analysis using gene prediction method: Protein Homology. (65 aa)
atpBF0F1 ATP synthase subunit A; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (237 aa)
atpFATP synthase F0 subunit B; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (164 aa)
atpHF0F1 ATP synthase subunit delta; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (178 aa)
atpAF0F1 ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (501 aa)
atpGF0F1 ATP synthase subunit gamma; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (291 aa)
atpDF0F1 ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (468 aa)
atpCF0F1 ATP synthase subunit epsilon; Produces ATP from ADP in the presence of a proton gradient across the membrane. (138 aa)
cmkCytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (226 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (279 aa)
prs-2Ribose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (323 aa)
APD31865.1GTP pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (223 aa)
nadKNAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (278 aa)
xptXanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (193 aa)
tdkThymidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (192 aa)
guaAGlutamine-hydrolyzing GMP synthase; Catalyzes the synthesis of GMP from XMP. (520 aa)
APD31782.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (112 aa)
APD31777.1Phosphopantothenate--cysteine ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (229 aa)
coaCPhosphopantothenoylcysteine decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (181 aa)
coaAType I pantothenate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (306 aa)
APD31750.1Riboflavin biosynthesis protein RibF; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribF family. (310 aa)
APD31705.1Dihydroorotase; Derived by automated computational analysis using gene prediction method: Protein Homology. (156 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (208 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (243 aa)
APD31658.1Nucleoside-diphosphate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (140 aa)
dacATIGR00159 family protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (281 aa)
APD31640.1Iron ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (471 aa)
APD31638.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (322 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (172 aa)
udkUridine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (208 aa)
APD31511.1Class 1b ribonucleoside-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (319 aa)
pyrDDihydroorotate oxidase; Catalyzes the conversion of dihydroorotate to orotate. (311 aa)
folDBifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (285 aa)
APD31447.1NUDIX hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (148 aa)
coaDPantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (163 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (535 aa)
APD31217.1GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (739 aa)
APD31194.1DNA topology modulation protein FlaR; Derived by automated computational analysis using gene prediction method: Protein Homology. (168 aa)
APD31188.1Phosphoribulokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (198 aa)
APD31120.1Deoxynucleoside kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (214 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (212 aa)
APD31021.1Adenylosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (430 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (321 aa)
hptHypoxanthine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (180 aa)
Your Current Organism:
Streptococcus iniae
NCBI taxonomy Id: 1346
Other names: ATCC 29178, CCUG 27303, CIP 102508, DSM 20576, LMG 14520, LMG:14520, S. iniae, Streptococcus shiloi, strain PW
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