(14 nodes) Thioredoxin-like superfamily network (Streptococcus iniae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	APD31831.1	Glutathione peroxidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutathione peroxidase family. (159 aa)
	tpx	Lipid hydroperoxide peroxidase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Tpx subfamily. (163 aa)
	arsC	Arsenate reductase (glutaredoxin); Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ArsC family. (135 aa)
	spxA	Transcriptional regulator Spx; Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development- promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress. Belongs to the ArsC family. Spx subfamily. (134 aa)
	APD31112.1	Thiol reductase thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (105 aa)
	APD31229.1	Thiol reductase thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (113 aa)
	APD32054.1	Glutathione-dependent disulfide-bond oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GST superfamily. (258 aa)
	APD31513.1	NrdH-redoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (72 aa)
	APD32256.1	Arsenate reductase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ArsC family. (118 aa)
	trxA	Thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thioredoxin family. (104 aa)
	APD32679.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (195 aa)
	ahpC	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. (187 aa)
	APD32733.1	Alkyl hydroperoxide reductase subunit F; Derived by automated computational analysis using gene prediction method: Protein Homology. (510 aa)
	APD32757.1	Transcriptional regulator Spx; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ArsC family. (132 aa)

Your Current Organism:

Streptococcus iniae

NCBI taxonomy Id: 1346
Other names: ATCC 29178, CCUG 27303, CIP 102508, DSM 20576, LMG 14520, LMG:14520, S. iniae, Streptococcus shiloi, strain PW

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APD31229.1	APD32679.1	BMF34_01620	BMF34_09425	Thiol reductase thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.484
APD31229.1	APD32733.1	BMF34_01620	BMF34_09730	Thiol reductase thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	Alkyl hydroperoxide reductase subunit F; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.523
APD31229.1	ahpC	BMF34_01620	BMF34_09725	Thiol reductase thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.	0.603
APD31513.1	APD31831.1	BMF34_03240	BMF34_04930	NrdH-redoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	Glutathione peroxidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutathione peroxidase family.	0.738
APD31513.1	APD32054.1	BMF34_03240	BMF34_06100	NrdH-redoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	Glutathione-dependent disulfide-bond oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GST superfamily.	0.643
APD31513.1	ahpC	BMF34_03240	BMF34_09725	NrdH-redoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.	0.441
APD31831.1	APD31513.1	BMF34_04930	BMF34_03240	Glutathione peroxidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutathione peroxidase family.	NrdH-redoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.738
APD31831.1	APD32054.1	BMF34_04930	BMF34_06100	Glutathione peroxidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutathione peroxidase family.	Glutathione-dependent disulfide-bond oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GST superfamily.	0.650
APD31831.1	ahpC	BMF34_04930	BMF34_09725	Glutathione peroxidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutathione peroxidase family.	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.	0.814
APD32054.1	APD31513.1	BMF34_06100	BMF34_03240	Glutathione-dependent disulfide-bond oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GST superfamily.	NrdH-redoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.643
APD32054.1	APD31831.1	BMF34_06100	BMF34_04930	Glutathione-dependent disulfide-bond oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GST superfamily.	Glutathione peroxidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutathione peroxidase family.	0.650
APD32054.1	ahpC	BMF34_06100	BMF34_09725	Glutathione-dependent disulfide-bond oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GST superfamily.	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.	0.696
APD32256.1	APD32757.1	BMF34_07155	BMF34_09855	Arsenate reductase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ArsC family.	Transcriptional regulator Spx; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ArsC family.	0.634
APD32679.1	APD31229.1	BMF34_09425	BMF34_01620	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Thiol reductase thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.484
APD32679.1	ahpC	BMF34_09425	BMF34_09725	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.	0.410
APD32679.1	trxA	BMF34_09425	BMF34_08580	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thioredoxin family.	0.484
APD32733.1	APD31229.1	BMF34_09730	BMF34_01620	Alkyl hydroperoxide reductase subunit F; Derived by automated computational analysis using gene prediction method: Protein Homology.	Thiol reductase thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.523
APD32733.1	ahpC	BMF34_09730	BMF34_09725	Alkyl hydroperoxide reductase subunit F; Derived by automated computational analysis using gene prediction method: Protein Homology.	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.	0.994
APD32733.1	trxA	BMF34_09730	BMF34_08580	Alkyl hydroperoxide reductase subunit F; Derived by automated computational analysis using gene prediction method: Protein Homology.	Thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thioredoxin family.	0.559
APD32757.1	APD32256.1	BMF34_09855	BMF34_07155	Transcriptional regulator Spx; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ArsC family.	Arsenate reductase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ArsC family.	0.634