(52 nodes) Infectious disease network (Streptococcus iniae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	APD31024.1	Protein tyrosine phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. (150 aa)
	secY	Preprotein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (434 aa)
	rpoA	DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (312 aa)
	APD31079.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (112 aa)
	APD31080.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (97 aa)
	rpoB	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1187 aa)
	rpoC	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1210 aa)
	APD31123.1	Adhesin; Derived by automated computational analysis using gene prediction method: Protein Homology. (1194 aa)
	APD31144.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (167 aa)
	APD31190.1	FMN adenylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (397 aa)
	APD31229.1	Thiol reductase thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (113 aa)
	APD31241.1	MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (389 aa)
	APD31338.1	Peptide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (499 aa)
	APD31339.1	Peptide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (308 aa)
	secY2	Accessory Sec system protein translocase subunit SecY2; Part of the accessory SecA2/SecY2 system specifically required for export of possible cell wall proteins. The central subunit of a protein translocation channel. (421 aa)
	secA2	Accessory Sec system translocase SecA2; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. (792 aa)
	APD31429.1	Multidrug ABC transporter permease/ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (580 aa)
	APD31430.1	Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (584 aa)
	sodA	Superoxide dismutase; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. (202 aa)
	APD31524.1	Internalin; Derived by automated computational analysis using gene prediction method: Protein Homology. (759 aa)
	APD31570.1	MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (406 aa)
	APD31575.1	Sugar ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (573 aa)
	APD31576.1	Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (576 aa)
	APD31640.1	Iron ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (471 aa)
	APD31658.1	Nucleoside-diphosphate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (140 aa)
	tpx	Lipid hydroperoxide peroxidase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Tpx subfamily. (163 aa)
	APD31754.1	Phosphate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (288 aa)
	APD31921.1	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (580 aa)
	APD31922.1	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (573 aa)
	APD31925.1	Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (588 aa)
	APD31926.1	Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (580 aa)
	BMF34_05510	Hypothetical protein; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (332 aa)
	tuf	Translation elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (398 aa)
	APD32102.1	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (375 aa)
	APD32134.1	Phosphate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (226 aa)
	APD32195.1	Preprotein translocase subunit SecG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. (78 aa)
	msrA	Peptide-methionine (S)-S-oxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (178 aa)
	rpoZ	DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (105 aa)
	trxB	Thioredoxin-disulfide reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (304 aa)
	APD32485.1	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (561 aa)
	secA	Preprotein translocase subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane; Belongs to the SecA family. (844 aa)
	trxA	Thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thioredoxin family. (104 aa)
	APD32548.1	Type VII secretion protein EsxA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the WXG100 family. (96 aa)
	APD32588.1	Peptide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (343 aa)
	APD32589.1	Peptide ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (304 aa)
	APD32665.1	Multidrug ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (594 aa)
	APD32666.1	Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (569 aa)
	APD32679.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (195 aa)
	APD32681.1	Histidine triad protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (841 aa)
	APD32717.1	Preprotein translocase subunit SecE; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SecE/SEC61-gamma family. (58 aa)
	ahpC	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. (187 aa)
	APD32762.1	MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (407 aa)

Your Current Organism:

Streptococcus iniae

NCBI taxonomy Id: 1346
Other names: ATCC 29178, CCUG 27303, CIP 102508, DSM 20576, LMG 14520, LMG:14520, S. iniae, Streptococcus shiloi, strain PW

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APD31024.1	APD31229.1	BMF34_00420	BMF34_01620	Protein tyrosine phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the low molecular weight phosphotyrosine protein phosphatase family.	Thiol reductase thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.767
APD31024.1	APD31429.1	BMF34_00420	BMF34_02800	Protein tyrosine phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the low molecular weight phosphotyrosine protein phosphatase family.	Multidrug ABC transporter permease/ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.486
APD31024.1	APD31430.1	BMF34_00420	BMF34_02805	Protein tyrosine phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the low molecular weight phosphotyrosine protein phosphatase family.	Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.486
APD31024.1	APD31575.1	BMF34_00420	BMF34_03570	Protein tyrosine phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the low molecular weight phosphotyrosine protein phosphatase family.	Sugar ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.486
APD31024.1	APD31576.1	BMF34_00420	BMF34_03575	Protein tyrosine phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the low molecular weight phosphotyrosine protein phosphatase family.	Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.486
APD31024.1	APD31921.1	BMF34_00420	BMF34_05400	Protein tyrosine phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the low molecular weight phosphotyrosine protein phosphatase family.	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.486
APD31024.1	APD31922.1	BMF34_00420	BMF34_05405	Protein tyrosine phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the low molecular weight phosphotyrosine protein phosphatase family.	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.486
APD31024.1	APD31925.1	BMF34_00420	BMF34_05425	Protein tyrosine phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the low molecular weight phosphotyrosine protein phosphatase family.	Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.486
APD31024.1	APD31926.1	BMF34_00420	BMF34_05430	Protein tyrosine phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the low molecular weight phosphotyrosine protein phosphatase family.	Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.486
APD31024.1	APD32485.1	BMF34_00420	BMF34_08415	Protein tyrosine phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the low molecular weight phosphotyrosine protein phosphatase family.	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.486
APD31024.1	APD32665.1	BMF34_00420	BMF34_09345	Protein tyrosine phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the low molecular weight phosphotyrosine protein phosphatase family.	Multidrug ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.486
APD31024.1	APD32666.1	BMF34_00420	BMF34_09350	Protein tyrosine phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the low molecular weight phosphotyrosine protein phosphatase family.	Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.486
APD31024.1	trxA	BMF34_00420	BMF34_08580	Protein tyrosine phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the low molecular weight phosphotyrosine protein phosphatase family.	Thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thioredoxin family.	0.767
APD31079.1	APD31080.1	BMF34_00810	BMF34_00815	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.946
APD31080.1	APD31079.1	BMF34_00815	BMF34_00810	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.946
APD31229.1	APD31024.1	BMF34_01620	BMF34_00420	Thiol reductase thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	Protein tyrosine phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the low molecular weight phosphotyrosine protein phosphatase family.	0.767
APD31229.1	APD31524.1	BMF34_01620	BMF34_03300	Thiol reductase thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	Internalin; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.464
APD31229.1	APD31640.1	BMF34_01620	BMF34_03900	Thiol reductase thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	Iron ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.497
APD31229.1	APD31658.1	BMF34_01620	BMF34_03990	Thiol reductase thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	Nucleoside-diphosphate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.511
APD31229.1	APD32102.1	BMF34_01620	BMF34_06350	Thiol reductase thioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.817