(11 nodes) Mixed, incl. HPT domain superfamily, and Histidine kinase-like ATPase domain network (Actinoplanes sp. SE50110)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	ACPL_2260	Sensor histidine kinase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (952 aa)
	ACPL_2274	Two-component system, cell cycle sensor kinase and response regulator; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. (525 aa)
	ACPL_2318	Signal transduction histidine kinase. (825 aa)
	phoR	Sensory box histidine kinase PhoR; Signal transduction histidine kinase. (653 aa)
	barA	Sensory box histidine kinase/response regulator; Signal transduction histidine kinase. (1418 aa)
	ACPL_3427	Two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR; Osmosensitive K+ channel histidine kinase. (715 aa)
	ACPL_3519	Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain. (1038 aa)
	ACPL_3707	Sensor histidine kinase/response regulator; FOG: HAMP domain. (1498 aa)
	ACPL_398	GAF sensor hybrid histidine kinase; FOG: HAMP domain. (1465 aa)
	ACPL_4649	Response regulator receiver sensor signal transduction histidine kinase; Serine phosphatase RsbU, regulator of sigma subunit. (1346 aa)
	ACPL_4809	Two-component system sensor protein; Signal transduction histidine kinase. (774 aa)

Your Current Organism:

Actinoplanes sp. SE50110

NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACPL_2260	ACPL_2274	ACPL_2260	ACPL_2274	Sensor histidine kinase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.	Two-component system, cell cycle sensor kinase and response regulator; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	0.991
ACPL_2260	ACPL_2318	ACPL_2260	ACPL_2318	Sensor histidine kinase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.	Signal transduction histidine kinase.	0.993
ACPL_2260	ACPL_3427	ACPL_2260	ACPL_3427	Sensor histidine kinase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.	Two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR; Osmosensitive K+ channel histidine kinase.	0.991
ACPL_2260	ACPL_3519	ACPL_2260	ACPL_3519	Sensor histidine kinase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.	Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain.	0.976
ACPL_2260	ACPL_3707	ACPL_2260	ACPL_3707	Sensor histidine kinase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.	Sensor histidine kinase/response regulator; FOG: HAMP domain.	0.990
ACPL_2260	ACPL_398	ACPL_2260	ACPL_398	Sensor histidine kinase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.	GAF sensor hybrid histidine kinase; FOG: HAMP domain.	0.994
ACPL_2260	ACPL_4649	ACPL_2260	ACPL_4649	Sensor histidine kinase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.	Response regulator receiver sensor signal transduction histidine kinase; Serine phosphatase RsbU, regulator of sigma subunit.	0.992
ACPL_2260	ACPL_4809	ACPL_2260	ACPL_4809	Sensor histidine kinase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.	Two-component system sensor protein; Signal transduction histidine kinase.	0.993
ACPL_2260	barA	ACPL_2260	ACPL_3376	Sensor histidine kinase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.	Sensory box histidine kinase/response regulator; Signal transduction histidine kinase.	0.992
ACPL_2260	phoR	ACPL_2260	ACPL_2443	Sensor histidine kinase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.	Sensory box histidine kinase PhoR; Signal transduction histidine kinase.	0.991
ACPL_2274	ACPL_2260	ACPL_2274	ACPL_2260	Two-component system, cell cycle sensor kinase and response regulator; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	Sensor histidine kinase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.	0.991
ACPL_2274	ACPL_2318	ACPL_2274	ACPL_2318	Two-component system, cell cycle sensor kinase and response regulator; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	Signal transduction histidine kinase.	0.992
ACPL_2274	ACPL_3427	ACPL_2274	ACPL_3427	Two-component system, cell cycle sensor kinase and response regulator; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	Two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR; Osmosensitive K+ channel histidine kinase.	0.997
ACPL_2274	ACPL_3519	ACPL_2274	ACPL_3519	Two-component system, cell cycle sensor kinase and response regulator; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain.	0.976
ACPL_2274	ACPL_3707	ACPL_2274	ACPL_3707	Two-component system, cell cycle sensor kinase and response regulator; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	Sensor histidine kinase/response regulator; FOG: HAMP domain.	0.991
ACPL_2274	ACPL_398	ACPL_2274	ACPL_398	Two-component system, cell cycle sensor kinase and response regulator; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	GAF sensor hybrid histidine kinase; FOG: HAMP domain.	0.992
ACPL_2274	ACPL_4649	ACPL_2274	ACPL_4649	Two-component system, cell cycle sensor kinase and response regulator; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	Response regulator receiver sensor signal transduction histidine kinase; Serine phosphatase RsbU, regulator of sigma subunit.	0.998
ACPL_2274	ACPL_4809	ACPL_2274	ACPL_4809	Two-component system, cell cycle sensor kinase and response regulator; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	Two-component system sensor protein; Signal transduction histidine kinase.	0.993
ACPL_2274	barA	ACPL_2274	ACPL_3376	Two-component system, cell cycle sensor kinase and response regulator; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	Sensory box histidine kinase/response regulator; Signal transduction histidine kinase.	0.993
ACPL_2274	phoR	ACPL_2274	ACPL_2443	Two-component system, cell cycle sensor kinase and response regulator; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	Sensory box histidine kinase PhoR; Signal transduction histidine kinase.	0.993