(5 nodes) HPT domain superfamily, and Histidine kinase-like ATPase domain network (Actinoplanes sp. SE50110)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ACPL_2274	Two-component system, cell cycle sensor kinase and response regulator; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain. (525 aa)
	ACPL_2318	Signal transduction histidine kinase. (825 aa)
	ACPL_3427	Two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR; Osmosensitive K+ channel histidine kinase. (715 aa)
	ACPL_4649	Response regulator receiver sensor signal transduction histidine kinase; Serine phosphatase RsbU, regulator of sigma subunit. (1346 aa)
	ACPL_4809	Two-component system sensor protein; Signal transduction histidine kinase. (774 aa)

Your Current Organism:

Actinoplanes sp. SE50110

NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
ACPL_2274	ACPL_2318	Two-component system, cell cycle sensor kinase and response regulator; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	Signal transduction histidine kinase.	0.992
ACPL_2274	ACPL_3427	Two-component system, cell cycle sensor kinase and response regulator; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	Two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR; Osmosensitive K+ channel histidine kinase.	0.997
ACPL_2274	ACPL_4649	Two-component system, cell cycle sensor kinase and response regulator; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	Response regulator receiver sensor signal transduction histidine kinase; Serine phosphatase RsbU, regulator of sigma subunit.	0.998
ACPL_2274	ACPL_4809	Two-component system, cell cycle sensor kinase and response regulator; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	Two-component system sensor protein; Signal transduction histidine kinase.	0.993
ACPL_2318	ACPL_2274	Signal transduction histidine kinase.	Two-component system, cell cycle sensor kinase and response regulator; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	0.992
ACPL_2318	ACPL_3427	Signal transduction histidine kinase.	Two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR; Osmosensitive K+ channel histidine kinase.	0.994
ACPL_2318	ACPL_4649	Signal transduction histidine kinase.	Response regulator receiver sensor signal transduction histidine kinase; Serine phosphatase RsbU, regulator of sigma subunit.	0.999
ACPL_2318	ACPL_4809	Signal transduction histidine kinase.	Two-component system sensor protein; Signal transduction histidine kinase.	0.993
ACPL_3427	ACPL_2274	Two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR; Osmosensitive K+ channel histidine kinase.	Two-component system, cell cycle sensor kinase and response regulator; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	0.997
ACPL_3427	ACPL_2318	Two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR; Osmosensitive K+ channel histidine kinase.	Signal transduction histidine kinase.	0.994
ACPL_3427	ACPL_4649	Two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR; Osmosensitive K+ channel histidine kinase.	Response regulator receiver sensor signal transduction histidine kinase; Serine phosphatase RsbU, regulator of sigma subunit.	0.997
ACPL_3427	ACPL_4809	Two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR; Osmosensitive K+ channel histidine kinase.	Two-component system sensor protein; Signal transduction histidine kinase.	0.994
ACPL_4649	ACPL_2274	Response regulator receiver sensor signal transduction histidine kinase; Serine phosphatase RsbU, regulator of sigma subunit.	Two-component system, cell cycle sensor kinase and response regulator; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	0.998
ACPL_4649	ACPL_2318	Response regulator receiver sensor signal transduction histidine kinase; Serine phosphatase RsbU, regulator of sigma subunit.	Signal transduction histidine kinase.	0.999
ACPL_4649	ACPL_3427	Response regulator receiver sensor signal transduction histidine kinase; Serine phosphatase RsbU, regulator of sigma subunit.	Two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR; Osmosensitive K+ channel histidine kinase.	0.997
ACPL_4649	ACPL_4809	Response regulator receiver sensor signal transduction histidine kinase; Serine phosphatase RsbU, regulator of sigma subunit.	Two-component system sensor protein; Signal transduction histidine kinase.	0.999
ACPL_4809	ACPL_2274	Two-component system sensor protein; Signal transduction histidine kinase.	Two-component system, cell cycle sensor kinase and response regulator; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain.	0.993
ACPL_4809	ACPL_2318	Two-component system sensor protein; Signal transduction histidine kinase.	Signal transduction histidine kinase.	0.993
ACPL_4809	ACPL_3427	Two-component system sensor protein; Signal transduction histidine kinase.	Two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR; Osmosensitive K+ channel histidine kinase.	0.994
ACPL_4809	ACPL_4649	Two-component system sensor protein; Signal transduction histidine kinase.	Response regulator receiver sensor signal transduction histidine kinase; Serine phosphatase RsbU, regulator of sigma subunit.	0.999