STRINGSTRING
ACPL_1100 ACPL_1100 ssb ssb ACPL_1392 ACPL_1392 dnaG dnaG pcrA pcrA ACPL_1659 ACPL_1659 dnaE-2 dnaE-2 polA polA uvrB uvrB uvrA uvrA uvrC uvrC dinB dinB lexA lexA ACPL_2693 ACPL_2693 polA-2 polA-2 topA topA holB holB ACPL_506 ACPL_506 drrC drrC ACPL_526 ACPL_526 lexA-2 lexA-2 ssb-2 ssb-2 ACPL_5832 ACPL_5832 dnaG-2 dnaG-2 ruvB ruvB ruvA ruvA ruvC ruvC dnaQ dnaQ dinP dinP ACPL_708 ACPL_708 recX recX recA recA ACPL_7611 ACPL_7611 ACPL_7625 ACPL_7625 ACPL_7626 ACPL_7626 ACPL_7634 ACPL_7634 ACPL_7700 ACPL_7700 xseA xseA xseB xseB ACPL_7829 ACPL_7829 dinG dinG radA radA disA disA dnaZ dnaZ ACPL_8324 ACPL_8324 dnaB-3 dnaB-3 ssb-3 ssb-3 pcrA-2 pcrA-2 trcF trcF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACPL_1100Laminin subunit beta-2. (466 aa)
ssbSingle-stranded DNA-binding protein. (215 aa)
ACPL_1392DNA polymerase III, delta subunit. (327 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (617 aa)
pcrASuperfamily I DNA and RNA helicases. (643 aa)
ACPL_1659DNA polymerase III subunit epsilon; Nuclease subunit of the excinuclease complex. (603 aa)
dnaE-2DNA polymerase III, alpha subunit. (1176 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (899 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (733 aa)
uvrAUvrABC system protein A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (985 aa)
uvrCUvrABC system protein C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (661 aa)
dinBDNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (504 aa)
lexARepressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (215 aa)
ACPL_2693Hypothetical protein. (586 aa)
polA-2DNA polymerase I; 5'-3' exonuclease (including N-terminal domain of PolI). (331 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (926 aa)
holBDNA polymerase III subunit delta; ATPase involved in DNA replication. (394 aa)
ACPL_506Hypothetical protein. (575 aa)
drrCUvrABC system protein A; Excinuclease ATPase subunit. (762 aa)
ACPL_526DNA excision repair protein ERCC-3; DNA or RNA helicases of superfamily II. (548 aa)
lexA-2Repressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (212 aa)
ssb-2Single-stranded DNA-binding protein. (164 aa)
ACPL_5832Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (351 aa)
dnaG-2DNA primase (bacterial type). (408 aa)
ruvBHolliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (348 aa)
ruvAHolliday junction ATP-dependent DNA helicase ruvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (200 aa)
ruvCHolliday junction resolvase; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (175 aa)
dnaQDNA polymerase III, alpha subunit (gram-positive type). (401 aa)
dinPDNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (391 aa)
ACPL_708Superfamily II DNA helicase. (708 aa)
recXRegulatory protein recX; Modulates RecA activity; Belongs to the RecX family. (151 aa)
recARecombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (361 aa)
ACPL_7611Superfamily I DNA and RNA helicases. (708 aa)
ACPL_7625Superfamily I DNA and RNA helicases; Belongs to the helicase family. UvrD subfamily. (1221 aa)
ACPL_7626Superfamily I DNA and RNA helicases; Belongs to the helicase family. UvrD subfamily. (1354 aa)
ACPL_7634DNA polymerase sliding clamp subunit (PCNA homolog). (346 aa)
ACPL_7700Hypothetical protein. (180 aa)
xseAExodeoxyribonuclease VII large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (414 aa)
xseBExodeoxyribonuclease 7 small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (67 aa)
ACPL_7829Uncharacterized protein; DNA repair photolyase. (643 aa)
dinGRad3-related DNA helicases. (632 aa)
radADNA repair protein RadA/Sms; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (472 aa)
disADNA integrity scanning protein disA; Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process. (393 aa)
dnaZDNA polymerase III, gamma/tau subunits. (1175 aa)
ACPL_8324Superfamily I DNA and RNA helicases. (1038 aa)
dnaB-3Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (427 aa)
ssb-3Single-stranded DNA-binding protein. (190 aa)
pcrA-2Superfamily I DNA and RNA helicases. (865 aa)
trcFTranscription-repair coupling factor (superfamily II helicase); Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1203 aa)
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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