(13 nodes) DNA replication network (Actinoplanes sp. SE50110)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ssb	Single-stranded DNA-binding protein. (215 aa)
	ACPL_1392	DNA polymerase III, delta subunit. (327 aa)
	dnaG	DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (617 aa)
	ACPL_1659	DNA polymerase III subunit epsilon; Nuclease subunit of the excinuclease complex. (603 aa)
	dnaE-2	DNA polymerase III, alpha subunit. (1176 aa)
	holB	DNA polymerase III subunit delta; ATPase involved in DNA replication. (394 aa)
	ssb-2	Single-stranded DNA-binding protein. (164 aa)
	ACPL_5832	Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (351 aa)
	dnaG-2	DNA primase (bacterial type). (408 aa)
	dnaQ	DNA polymerase III, alpha subunit (gram-positive type). (401 aa)
	dnaZ	DNA polymerase III, gamma/tau subunits. (1175 aa)
	dnaB-3	Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (427 aa)
	ssb-3	Single-stranded DNA-binding protein. (190 aa)

Your Current Organism:

Actinoplanes sp. SE50110

NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACPL_1392	ACPL_1659	ACPL_1392	ACPL_1659	DNA polymerase III, delta subunit.	DNA polymerase III subunit epsilon; Nuclease subunit of the excinuclease complex.	0.958
ACPL_1392	dnaE-2	ACPL_1392	ACPL_1776	DNA polymerase III, delta subunit.	DNA polymerase III, alpha subunit.	0.993
ACPL_1392	dnaG	ACPL_1392	ACPL_1453	DNA polymerase III, delta subunit.	DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.	0.442
ACPL_1392	dnaQ	ACPL_1392	ACPL_6692	DNA polymerase III, delta subunit.	DNA polymerase III, alpha subunit (gram-positive type).	0.960
ACPL_1392	dnaZ	ACPL_1392	ACPL_8134	DNA polymerase III, delta subunit.	DNA polymerase III, gamma/tau subunits.	0.993
ACPL_1392	holB	ACPL_1392	ACPL_496	DNA polymerase III, delta subunit.	DNA polymerase III subunit delta; ATPase involved in DNA replication.	0.995
ACPL_1392	ssb	ACPL_1392	ACPL_1290	DNA polymerase III, delta subunit.	Single-stranded DNA-binding protein.	0.495
ACPL_1659	ACPL_1392	ACPL_1659	ACPL_1392	DNA polymerase III subunit epsilon; Nuclease subunit of the excinuclease complex.	DNA polymerase III, delta subunit.	0.958
ACPL_1659	dnaE-2	ACPL_1659	ACPL_1776	DNA polymerase III subunit epsilon; Nuclease subunit of the excinuclease complex.	DNA polymerase III, alpha subunit.	0.954
ACPL_1659	dnaG	ACPL_1659	ACPL_1453	DNA polymerase III subunit epsilon; Nuclease subunit of the excinuclease complex.	DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.	0.554
ACPL_1659	dnaG-2	ACPL_1659	ACPL_5940	DNA polymerase III subunit epsilon; Nuclease subunit of the excinuclease complex.	DNA primase (bacterial type).	0.554
ACPL_1659	dnaQ	ACPL_1659	ACPL_6692	DNA polymerase III subunit epsilon; Nuclease subunit of the excinuclease complex.	DNA polymerase III, alpha subunit (gram-positive type).	0.955
ACPL_1659	dnaZ	ACPL_1659	ACPL_8134	DNA polymerase III subunit epsilon; Nuclease subunit of the excinuclease complex.	DNA polymerase III, gamma/tau subunits.	0.953
ACPL_1659	holB	ACPL_1659	ACPL_496	DNA polymerase III subunit epsilon; Nuclease subunit of the excinuclease complex.	DNA polymerase III subunit delta; ATPase involved in DNA replication.	0.961
ACPL_1659	ssb	ACPL_1659	ACPL_1290	DNA polymerase III subunit epsilon; Nuclease subunit of the excinuclease complex.	Single-stranded DNA-binding protein.	0.412
ACPL_1659	ssb-2	ACPL_1659	ACPL_5803	DNA polymerase III subunit epsilon; Nuclease subunit of the excinuclease complex.	Single-stranded DNA-binding protein.	0.412
ACPL_1659	ssb-3	ACPL_1659	ACPL_8344	DNA polymerase III subunit epsilon; Nuclease subunit of the excinuclease complex.	Single-stranded DNA-binding protein.	0.412
ACPL_5832	dnaB-3	ACPL_5832	ACPL_8338	Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily.	Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily.	0.901
ACPL_5832	dnaE-2	ACPL_5832	ACPL_1776	Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily.	DNA polymerase III, alpha subunit.	0.654
ACPL_5832	dnaG	ACPL_5832	ACPL_1453	Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily.	DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.	0.903