STRINGSTRING
whiB-5 whiB-5 fdhF fdhF thiC thiC moaA moaA wblB wblB udgB udgB ACPL_7829 ACPL_7829 fumB fumB mutY mutY ispH ispH nth nth fbiC fbiC whiB whiB ACPL_1403 ACPL_1403 lipA lipA nadA nadA acnA acnA ACPL_2006 ACPL_2006 ACPL_2123 ACPL_2123 purF purF ACPL_2394 ACPL_2394 ACPL_2806 ACPL_2806 ACPL_2857 ACPL_2857 ACPL_3344 ACPL_3344 mqnE mqnE mqnC mqnC nuoB nuoB ACPL_450 ACPL_450 nuoG nuoG sdaA sdaA nuoI nuoI ACPL_5000 ACPL_5000 ACPL_5341 ACPL_5341 ACPL_5754 ACPL_5754 ACPL_5755 ACPL_5755 ACPL_6027 ACPL_6027 ACPL_6084 ACPL_6084 bioB bioB ACPL_7123 ACPL_7123 miaB miaB ACPL_7174 ACPL_7174 rimO rimO ispG ispG rlmN rlmN leuC leuC nuoB-2 nuoB-2 nuoI-2 nuoI-2 whiB-2 whiB-2 cysH cysH nirA nirA whiB-3 whiB-3 whiB-4 whiB-4 ACPL_7645 ACPL_7645
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
whiB-5Transcription factor WhiB; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (100 aa)
fdhFMolybdopterin oxidoreductase; Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. (1307 aa)
thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (505 aa)
moaAMolybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (335 aa)
wblBTranscription factor WhiB; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (128 aa)
udgBUracil-DNA glycosylase. (225 aa)
ACPL_7829Uncharacterized protein; DNA repair photolyase. (643 aa)
fumBFumarate hydratase, class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (555 aa)
mutYA/G-specific DNA glycosylase. (298 aa)
ispH4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (320 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (267 aa)
fbiCFO synthase; Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes. (915 aa)
whiBTranscription factor WhiB; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (85 aa)
ACPL_1403Oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (400 aa)
lipALipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (298 aa)
nadAQuinolinate synthase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (389 aa)
acnAAconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (923 aa)
ACPL_2006Formate dehydrogenase, alpha subunit; Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (751 aa)
ACPL_2123Molybdopterin dinucleotide-binding region; Uncharacterized anaerobic dehydrogenase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (753 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (524 aa)
ACPL_2394Coproporphyrinogen III oxidase and related Fe-S oxidoreductases. (431 aa)
ACPL_2806Lysine 2,3-aminomutase. (454 aa)
ACPL_2857Anaerobic ribonucleoside-triphosphate reductase activating protein; Pyruvate-formate lyase-activating enzyme. (203 aa)
ACPL_3344Hypothetical protein. (182 aa)
mqnEFO synthase subunit 2 1; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. (389 aa)
mqnCRadical SAM domain-containing protein; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). (413 aa)
nuoBNADH dehydrogenase I subunit B; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (222 aa)
ACPL_450NADH dehydrogenase I subunit F; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. (438 aa)
nuoGNADH dehydrogenase I subunit G; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (831 aa)
sdaAL-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (434 aa)
nuoINADH dehydrogenase I subunit I; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (186 aa)
ACPL_5000Hypothetical protein. (435 aa)
ACPL_5341NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit. (492 aa)
ACPL_5754Formate dehydrogenase, alpha subunit; Anaerobic dehydrogenases, typically selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (840 aa)
ACPL_5755Formate dehydrogenase, alpha subunit; Uncharacterized anaerobic dehydrogenase. (189 aa)
ACPL_6027DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog; Belongs to the sigma-70 factor family. ECF subfamily. (151 aa)
ACPL_6084Lysine 2,3-aminomutase. (442 aa)
bioBBiotin synthetase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (331 aa)
ACPL_7123HhH-GPD family protein; Predicted EndoIII-related endonuclease. (194 aa)
miaBBifunctional enzyme involved in thiolation and methylation of tRNA; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (490 aa)
ACPL_7174DNA polymerase bacteriophage-type; Uracil-DNA glycosylase. (221 aa)
rimOMiaB-like tRNA modifying enzyme YliG; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (486 aa)
ispG4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (390 aa)
rlmNRibosomal RNA large subunit methyltransferase N; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (392 aa)
leuC3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (484 aa)
nuoB-2NADH dehydrogenase I subunit B; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (178 aa)
nuoI-2NADH dehydrogenase I subunit I; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (199 aa)
whiB-2Transcription factor WhiB; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (84 aa)
cysHPhosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (254 aa)
nirASulfite reductase, beta subunit (hemoprotein); Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (563 aa)
whiB-3Transcription factor WhiB; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (132 aa)
whiB-4Transcriptional regulatory protein WhiB-like WhiB7; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (120 aa)
ACPL_7645Ferredoxin 1; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (108 aa)
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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