STRINGSTRING
ACPL_1792 ACPL_1792 rmlB rmlB ACPL_3097 ACPL_3097 acbV acbV acbU acbU acbS acbS acbR acbR acbK acbK acbM acbM acbL acbL acbN acbN acbO acbO acbC acbC acbB acbB acbA acbA ACPL_6249 ACPL_6249 ACPL_6250 ACPL_6250 ACPL_6251 ACPL_6251
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACPL_1792PfkB domain protein; Sugar kinases, ribokinase family. (296 aa)
rmlBdTDP-D-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (325 aa)
ACPL_3097Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (290 aa)
acbVdTDP-4-keto-6-deoxy-glucose 4-aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (431 aa)
acbU1-epi-valienol-7-phosphate 1-kinase. (492 aa)
acbSGlycosyltransferase. (709 aa)
acbR1-epi-valienol-1, 7-bisphosphate-1-adenylyltransferase. (363 aa)
acbKAcarbose 7-kinase; Catalyzes the phosphorylation of the alpha-glucosidase inhibitor acarbose. Phosphorylation of acarbose could be a resistance- like self-protection mechanism; Belongs to the carbohydrate kinase PfkB family. (299 aa)
acbM2-epi-5-epi-valiolone 7-kinase; Catalyzes the conversion of 2-epi-5-epi-valiolone to 2-epi-5- epi-valiolone 7-phosphate. Involved in the biosynthesis of the acarviose moiety of the alpha-glucosidase inhibitor acarbose. Belongs to the ROK (NagC/XylR) family. (359 aa)
acbLCyclitol dehydrogenase. (366 aa)
acbNCyclitol oxidoreductase. (251 aa)
acbO2-epi-5-epi-valiolone-7-phosphate 2-epimerase; Involved in the biosynthesis of the alpha-glucosidase inhibitor acarbose. Catalyzes the 2-epimerisation of 2-epi-5- epivaliolone 7-phosphate to yield 5-epi-valiolone 7-phosphate. Belongs to the hyi family. (270 aa)
acbC2-epi-5-epi-valiolone synthase; Catalyzes the cyclization of D-sedoheptulose 7-phosphate to 2-epi-5-epi-valiolone. Does not use ido-heptulose 7-phosphate and 3- deoxy-arabino-heptulosonate 7-phosphate. Involved in the biosynthesis of the acarviose moiety of the alpha-glucosidase inhibitor acarbose. Belongs to the sugar phosphate cyclases superfamily. EEVS family. (398 aa)
acbBdTDP-glucose 4,6-dehydratase; Probably involved in the biosynthesis of the acarviose moiety of the alpha-glucosidase inhibitor acarbose. Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6-deoxy-D- xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction (By similarity). Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (320 aa)
acbAGlucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis; Belongs to the glucose-1-phosphate thymidylyltransferase family. (278 aa)
ACPL_6249Glucose kinase; Transcriptional regulator/sugar kinase. (284 aa)
ACPL_62503-dehydroquinate synthetase. (264 aa)
ACPL_6251L-threonine 3-dehydrogenase; Zn-dependent alcohol dehydrogenases. (364 aa)
Your Current Organism:
Actinoplanes sp. SE50110
NCBI taxonomy Id: 134676
Other names: A. sp. SE50/110, Actinoplanes sp. (strain 50/110), Actinoplanes sp. 50/110, Actinoplanes sp. SE50/110
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