(9 nodes) Thiamine metabolism network (Lactococcus raffinolactis NBRC100932)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	rsgA	Unannotated protein; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. (294 aa)
	CMV25_08375	Unannotated protein. (266 aa)
	CMV25_09495	Unannotated protein. (173 aa)
	CMV25_06345	Unannotated protein. (380 aa)
	thiI	Unannotated protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (407 aa)
	CMV25_08770	Unannotated protein. (218 aa)
	GCA_001591765_00602	Unannotated protein. (164 aa)
	adk	Unannotated protein; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (215 aa)
	CMV25_08060	Unannotated protein. (377 aa)

Your Current Organism:

Lactococcus raffinolactis NBRC100932

NCBI taxonomy Id: 1348633
Other names: L. raffinolactis NBRC 100932, Lactococcus raffinolactis NBRC 100932

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CMV25_06345	CMV25_08060	GCA_001591765_00081	GCA_001591765_01272	Unannotated protein.	Unannotated protein.	0.943
CMV25_06345	thiI	GCA_001591765_00081	GCA_001591765_00082	Unannotated protein.	Unannotated protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.	0.990
CMV25_08060	CMV25_06345	GCA_001591765_01272	GCA_001591765_00081	Unannotated protein.	Unannotated protein.	0.943
CMV25_08060	thiI	GCA_001591765_01272	GCA_001591765_00082	Unannotated protein.	Unannotated protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.	0.960
CMV25_08375	rsgA	GCA_001591765_01640	GCA_001591765_01249	Unannotated protein.	Unannotated protein; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.	0.467
CMV25_08770	adk	GCA_001591765_00222	GCA_001591765_00824	Unannotated protein.	Unannotated protein; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.	0.873
CMV25_08770	rsgA	GCA_001591765_00222	GCA_001591765_01249	Unannotated protein.	Unannotated protein; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.	0.901
CMV25_09495	GCA_001591765_00602	GCA_001591765_02133	GCA_001591765_00602	Unannotated protein.	Unannotated protein.	0.716
GCA_001591765_00602	CMV25_09495	GCA_001591765_00602	GCA_001591765_02133	Unannotated protein.	Unannotated protein.	0.716
adk	CMV25_08770	GCA_001591765_00824	GCA_001591765_00222	Unannotated protein; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.	Unannotated protein.	0.873
rsgA	CMV25_08375	GCA_001591765_01249	GCA_001591765_01640	Unannotated protein; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.	Unannotated protein.	0.467
rsgA	CMV25_08770	GCA_001591765_01249	GCA_001591765_00222	Unannotated protein; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.	Unannotated protein.	0.901
thiI	CMV25_06345	GCA_001591765_00082	GCA_001591765_00081	Unannotated protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.	Unannotated protein.	0.990
thiI	CMV25_08060	GCA_001591765_00082	GCA_001591765_01272	Unannotated protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.	Unannotated protein.	0.960