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| | GCA_001591765_00776 | Unannotated protein. (482 aa) |
| | GCA_001591765_00777 | Unannotated protein. (180 aa) |
| | CMV25_04260 | Unannotated protein. (496 aa) |
| | ilvD | Unannotated protein; Belongs to the IlvD/Edd family. (570 aa) |
| | ilvB | Unannotated protein. (567 aa) |
| | ilvN | Unannotated protein. (158 aa) |
| | ilvC | Unannotated protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (340 aa) |
| | ilvA | Unannotated protein; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (416 aa) |
| | CMV25_10810 | Unannotated protein. (410 aa) |
| | acnA | Unannotated protein; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (869 aa) |
| | CMV25_10820 | Unannotated protein; Belongs to the citrate synthase family. (441 aa) |
| | argB | Unannotated protein; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (292 aa) |
| | argD | Unannotated protein. (378 aa) |
| | argJ | Unannotated protein; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (399 aa) |
| | argC | Unannotated protein; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (345 aa) |
| | GCA_001591765_00902 | Unannotated protein. (137 aa) |
| | CMV25_00630 | Unannotated protein. (331 aa) |
| | gpmA | Unannotated protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (231 aa) |
| | tpiA | Unannotated protein; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (252 aa) |
| | CMV25_07935 | Unannotated protein; Belongs to the PHP hydrolase family. HisK subfamily. (259 aa) |
| | CMV25_07950 | Unannotated protein; Belongs to the ribulose-phosphate 3-epimerase family. (215 aa) |
| | CMV25_07985 | Unannotated protein. (369 aa) |
| | CMV25_07990 | Unannotated protein. (388 aa) |
| | prs | Unannotated protein; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (321 aa) |
| | cysE | Unannotated protein. (197 aa) |
| | aroD | Unannotated protein; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (216 aa) |
| | GCA_001591765_01330 | Unannotated protein. (129 aa) |
| | CMV25_09700 | Unannotated protein. (283 aa) |
| | CMV25_09730 | Unannotated protein. (389 aa) |
| | aroE | Unannotated protein; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (272 aa) |
| | aroB | Unannotated protein; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (355 aa) |
| | eno | Unannotated protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (441 aa) |
| | CMV25_02670 | Unannotated protein; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1137 aa) |
| | fba | Unannotated protein. (293 aa) |
| | CMV25_04545 | Unannotated protein; Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate. (381 aa) |
| | dapD | Unannotated protein; Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate. (231 aa) |
| | pfkA | Unannotated protein; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (335 aa) |
| | pyk | Unannotated protein; Belongs to the pyruvate kinase family. (500 aa) |
| | CMV25_10465 | Unannotated protein. (426 aa) |
| | thrB | Unannotated protein; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (290 aa) |
| | prs-2 | Unannotated protein; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (327 aa) |
| | CMV25_08645 | Unannotated protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (393 aa) |
| | serC | Unannotated protein; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (365 aa) |
| | aroC | Unannotated protein; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (388 aa) |
| | CMV25_09820 | Unannotated protein. (367 aa) |
| | aroA | Unannotated protein; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (426 aa) |
| | CMV25_09875 | Unannotated protein. (197 aa) |
| | alsS | Unannotated protein; Belongs to the TPP enzyme family. (552 aa) |
| | glyA | Unannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa) |
| | argF | Unannotated protein; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (333 aa) |
| | CMV25_08345 | Unannotated protein; Belongs to the aspartokinase family. (450 aa) |
| | CMV25_10620 | Unannotated protein. (289 aa) |
| | CMV25_10615 | Unannotated protein. (322 aa) |
| | dapB | Unannotated protein; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (254 aa) |
| | metE | Unannotated protein; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (751 aa) |
| | cysK | Unannotated protein; Belongs to the cysteine synthase/cystathionine beta- synthase family. (308 aa) |
| | hisE | Unannotated protein. (104 aa) |
| | hisI | Unannotated protein; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (121 aa) |
| | hisF | Unannotated protein; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (252 aa) |
| | hisA | Unannotated protein. (237 aa) |
| | hisH | Unannotated protein; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (208 aa) |
| | hisB | Unannotated protein. (194 aa) |
| | serB | Unannotated protein. (217 aa) |
| | hisD | Unannotated protein; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (430 aa) |
| | hisG | Unannotated protein; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (213 aa) |
| | hisZ | Unannotated protein; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (319 aa) |
| | hisC | Unannotated protein; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (349 aa) |
| | metK | Unannotated protein; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (395 aa) |
| | CMV25_04960 | Unannotated protein. (391 aa) |
| | GCA_001591765_01887 | Unannotated protein. (170 aa) |
| | CMV25_07005 | Unannotated protein. (447 aa) |
| | CMV25_06985 | Unannotated protein. (152 aa) |
| | CMV25_01030 | Unannotated protein. (479 aa) |
| | CMV25_01035 | Unannotated protein. (1500 aa) |
| | kbaY | Unannotated protein. (281 aa) |
| | CMV25_03625 | Unannotated protein. (89 aa) |
| | GCA_001591765_02059 | Unannotated protein. (193 aa) |
| | pgk | Unannotated protein; Belongs to the phosphoglycerate kinase family. (398 aa) |
| | luxS | Unannotated protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (157 aa) |
| | CMV25_06390 | Unannotated protein; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (340 aa) |
| | rsmA | Unannotated protein; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (290 aa) |
| | argG | Unannotated protein; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (402 aa) |
| | argH | Unannotated protein. (464 aa) |
| | CMV25_06685 | Unannotated protein. (476 aa) |
| | CMV25_08910 | Unannotated protein. (228 aa) |
| | CMV25_08920 | Unannotated protein. (795 aa) |
| | CMV25_09205 | Unannotated protein. (381 aa) |
| | tkt | Unannotated protein; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (663 aa) |
| | asd | Unannotated protein; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (360 aa) |
| | dapA | Unannotated protein; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa) |
| | rex | Unannotated protein; Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. (221 aa) |
| | metAA | Unannotated protein; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (310 aa) |
| | CMV25_01575 | Unannotated protein; Belongs to the UPF0237 family. (88 aa) |
| | sdaAA | Unannotated protein; Belongs to the iron-sulfur dependent L-serine dehydratase family. (289 aa) |
| | sdaAB | Unannotated protein; Belongs to the iron-sulfur dependent L-serine dehydratase family. (223 aa) |
| | CMV25_01330 | Unannotated protein. (185 aa) |
| | trpD | Unannotated protein; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (334 aa) |
| | trpC | Unannotated protein; Belongs to the TrpC family. (256 aa) |
| | trpF | Unannotated protein; Belongs to the TrpF family. (205 aa) |
| | trpB | Unannotated protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (412 aa) |
| | trpA | Unannotated protein; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (257 aa) |
| | pepV | Unannotated protein. (472 aa) |
| | proB | Unannotated protein; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (266 aa) |
| | proA | Unannotated protein; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (413 aa) |
| | GCA_001591765_00480 | Unannotated protein. (395 aa) |
| | leuD | Unannotated protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (196 aa) |
| | leuC | Unannotated protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (457 aa) |
| | leuB | Unannotated protein; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (345 aa) |
| | leuA | Unannotated protein; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (521 aa) |
| | CMV25_03640 | Unannotated protein; Belongs to the glutamine synthetase family. (702 aa) |
| | glnA | Unannotated protein; Belongs to the glutamine synthetase family. (446 aa) |
| | CMV25_03765 | Unannotated protein; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (226 aa) |
| | proC | Unannotated protein; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (259 aa) |
| | CMV25_03910 | Unannotated protein; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (342 aa) |
| | CMV25_03915 | Unannotated protein; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (341 aa) |
| | rpiA | Unannotated protein; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (225 aa) |
| | CMV25_03995 | Unannotated protein. (196 aa) |
| | gap | Unannotated protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (337 aa) |
| | aroK | Unannotated protein; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (160 aa) |
| | pheA | Unannotated protein. (275 aa) |
| | CMV25_10055 | Unannotated protein. (416 aa) |
| | CMV25_10175 | Unannotated protein. (343 aa) |
