STRINGSTRING
miaA miaA hflX hflX hflK hflK hflC hflC C1M56_18510 C1M56_18510 dnaJ dnaJ dnaK dnaK grpE grpE GCA_000740015_00685 GCA_000740015_00685 lon lon clpX clpX clpP clpP C1M56_03575 C1M56_03575 C1M56_03580 C1M56_03580 C1M56_03585 C1M56_03585 hslO hslO C1M56_09960 C1M56_09960 C1M56_09770 C1M56_09770 hslV hslV hslU hslU groES groES groL groL C1M56_08835 C1M56_08835 clpB clpB ftsH ftsH clpS clpS C1M56_12140 C1M56_12140 C1M56_02510 C1M56_02510 C1M56_02145 C1M56_02145 malT malT
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
miaAUnannotated protein; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (310 aa)
hflXUnannotated protein; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. (429 aa)
hflKUnannotated protein; HflC and HflK could encode or regulate a protease. (400 aa)
hflCUnannotated protein; HflC and HflK could regulate a protease. (326 aa)
C1M56_18510Unannotated protein; Belongs to the small heat shock protein (HSP20) family. (144 aa)
dnaJUnannotated protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK [...] (380 aa)
dnaKUnannotated protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. (637 aa)
grpEUnannotated protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depe [...] (204 aa)
GCA_000740015_00685Unannotated protein. (313 aa)
lonUnannotated protein; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (784 aa)
clpXUnannotated protein; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (426 aa)
clpPUnannotated protein; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (208 aa)
C1M56_03575Unannotated protein. (286 aa)
C1M56_03580Unannotated protein. (309 aa)
C1M56_03585Unannotated protein. (149 aa)
hslOUnannotated protein; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. (296 aa)
C1M56_09960Unannotated protein; Belongs to the HSP15 family. (128 aa)
C1M56_09770Unannotated protein. (166 aa)
hslVUnannotated protein; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. (184 aa)
hslUUnannotated protein; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. (443 aa)
groESUnannotated protein; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (96 aa)
groLUnannotated protein; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (545 aa)
C1M56_08835Unannotated protein. (156 aa)
clpBUnannotated protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (857 aa)
ftsHUnannotated protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (654 aa)
clpSUnannotated protein; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. (106 aa)
C1M56_12140Unannotated protein; Belongs to the ClpA/ClpB family. (755 aa)
C1M56_02510Unannotated protein. (450 aa)
C1M56_02145Unannotated protein; Belongs to the small heat shock protein (HSP20) family. (140 aa)
malTUnannotated protein; Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto- oligosaccharides. Specifically binds to the promoter region of its target genes, recognizing a short DNA motif called the MalT box. (902 aa)
Your Current Organism:
Vibrio diazotrophicus
NCBI taxonomy Id: 1348635
Other names: V. diazotrophicus NBRC 103148, Vibrio diazotrophicus NBRC 103148
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.