STRINGSTRING
pycA pycA fabV fabV serBA serBA rpe rpe icd icd accD accD fbaA fbaA acnB acnB folD folD sucC sucC serA2 serA2 serC serC prsA prsA pck pck acs acs accA accA ilvA ilvA lpd lpd gcvT gcvT rpiB rpiB MARIT_0138 MARIT_0138 mutA mutA mutB mutB mdh mdh MARIT_0877 MARIT_0877 sdaA sdaA pfkA pfkA gapA gapA MARIT_1250 MARIT_1250 pdhB pdhB MARIT_0504 MARIT_0504 metF metF cysE cysE fhs fhs pdhC pdhC pdhA pdhA lpdA lpdA sucA sucA sucB sucB serA3 serA3 pgk pgk fbp fbp aceA aceA aceB aceB phbA phbA glyA glyA tkt tkt tkt-2 tkt-2 sucD sucD gcvP gcvP MARIT_0941 MARIT_0941 katB katB eno eno gltA gltA tal tal hbd hbd tpiA tpiA MARIT_2551 MARIT_2551 pgi pgi gcvH gcvH maeB maeB sdhB sdhB sdhA sdhA sdhC sdhC accC accC accB accB pykA pykA yqjC yqjC gpmI gpmI MARIT_0437 MARIT_0437 gapA2 gapA2 fumC fumC MARIT_1960 MARIT_1960
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pycAUnannotated protein; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1150 aa)
fabVUnannotated protein; Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon- carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP); Belongs to the TER reductase family. (395 aa)
serBAUnannotated protein; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (630 aa)
rpeUnannotated protein; Belongs to the ribulose-phosphate 3-epimerase family. (218 aa)
icdUnannotated protein; Belongs to the monomeric-type IDH family. (741 aa)
accDUnannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. (285 aa)
fbaAUnannotated protein; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (355 aa)
acnBUnannotated protein. (925 aa)
folDUnannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (291 aa)
sucCUnannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (398 aa)
serA2Unannotated protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (316 aa)
serCUnannotated protein; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (354 aa)
prsAUnannotated protein. (313 aa)
pckUnannotated protein; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (536 aa)
acsUnannotated protein; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (635 aa)
accAUnannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (317 aa)
ilvAUnannotated protein; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (420 aa)
lpdUnannotated protein. (466 aa)
gcvTUnannotated protein; The glycine cleavage system catalyzes the degradation of glycine. (360 aa)
rpiBUnannotated protein. (144 aa)
MARIT_0138Unannotated protein; Belongs to the enoyl-CoA hydratase/isomerase family. (275 aa)
mutAUnannotated protein. (448 aa)
mutBUnannotated protein. (687 aa)
mdhUnannotated protein; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (310 aa)
MARIT_0877Unannotated protein; Belongs to the ribose-phosphate pyrophosphokinase family. (280 aa)
sdaAUnannotated protein; Belongs to the iron-sulfur dependent L-serine dehydratase family. (474 aa)
pfkAUnannotated protein; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (327 aa)
gapAUnannotated protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (330 aa)
MARIT_1250Unannotated protein. (259 aa)
pdhBUnannotated protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (325 aa)
MARIT_0504Unannotated protein; Belongs to the thiolase-like superfamily. Thiolase family. (417 aa)
metFUnannotated protein; Belongs to the methylenetetrahydrofolate reductase family. (317 aa)
cysEUnannotated protein. (256 aa)
fhsUnannotated protein; Belongs to the formate--tetrahydrofolate ligase family. (561 aa)
pdhCUnannotated protein. (546 aa)
pdhAUnannotated protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (329 aa)
lpdAUnannotated protein. (462 aa)
sucAUnannotated protein. (924 aa)
sucBUnannotated protein; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (402 aa)
serA3Unannotated protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (314 aa)
pgkUnannotated protein; Belongs to the phosphoglycerate kinase family. (395 aa)
fbpUnannotated protein; Belongs to the FBPase class 1 family. (335 aa)
aceAUnannotated protein. (538 aa)
aceBUnannotated protein; Belongs to the malate synthase family. (531 aa)
phbAUnannotated protein; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
glyAUnannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (424 aa)
tktUnannotated protein. (316 aa)
tkt-2Unannotated protein. (281 aa)
sucDUnannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (293 aa)
gcvPUnannotated protein; Belongs to the GcvP family. (947 aa)
MARIT_0941Unannotated protein. (801 aa)
katBUnannotated protein; Belongs to the catalase family. (505 aa)
enoUnannotated protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (429 aa)
gltAUnannotated protein; Belongs to the citrate synthase family. (428 aa)
talUnannotated protein; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (217 aa)
hbdUnannotated protein. (295 aa)
tpiAUnannotated protein; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (252 aa)
MARIT_2551Unannotated protein. (388 aa)
pgiUnannotated protein; Belongs to the GPI family. (523 aa)
gcvHUnannotated protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (126 aa)
maeBUnannotated protein. (766 aa)
sdhBUnannotated protein. (248 aa)
sdhAUnannotated protein. (671 aa)
sdhCUnannotated protein. (224 aa)
accCUnannotated protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (445 aa)
accBUnannotated protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (161 aa)
pykAUnannotated protein; Belongs to the pyruvate kinase family. (475 aa)
yqjCUnannotated protein. (133 aa)
gpmIUnannotated protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (498 aa)
MARIT_0437Unannotated protein. (298 aa)
gapA2Unannotated protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (480 aa)
fumCUnannotated protein; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (465 aa)
MARIT_1960Unannotated protein. (434 aa)
Your Current Organism:
Tenacibaculum maritimum
NCBI taxonomy Id: 1349785
Other names: T. maritimum NCIMB 2154, Tenacibaculum maritimum ATCC 43398, Tenacibaculum maritimum NBRC 110778, Tenacibaculum maritimum NCIMB 2154
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