STRINGSTRING
ezrA_2 ezrA_2 cwlC cwlC rnhC rnhC zapA zapA CvpA CvpA mutS2 mutS2 ecsA_3 ecsA_3 traL traL rpoE rpoE Pbp1B Pbp1B YneF YneF DacA DacA Pbp2B Pbp2B AOM15493.1 AOM15493.1 spxA_1 spxA_1 AOM15593.1 AOM15593.1 AOM15594.1 AOM15594.1 AOM15595.1 AOM15595.1 AOM15605.1 AOM15605.1 AOM15606.1 AOM15606.1 yozE yozE AOM17587.1 AOM17587.1 AOM15700.1 AOM15700.1 suhB suhB typA_1 typA_1 AOM15703.1 AOM15703.1 ftsW_1 ftsW_1 AOM15706.1 AOM15706.1 AOM17590.1 AOM17590.1 AOM15707.1 AOM15707.1 rsmD rsmD coaD coaD ylbL ylbL AOM15776.1 AOM15776.1 AmiC AmiC ponA ponA recU recU ypsA ypsA gpsB gpsB prpA prpA Pbp5 Pbp5 Psr Psr FtsW3 FtsW3 AOM15931.1 AOM15931.1 ArsC3 ArsC3 prsA_1 prsA_1 murC murC AOM16068.1 AOM16068.1 disA disA DsbG DsbG ltaS1_1 ltaS1_1 DivIVA DivIVA AOM16275.1 AOM16275.1 AOM16276.1 AOM16276.1 sepF_1 sepF_1 Alr2 Alr2 ftsZ_1 ftsZ_1 ftsA_1 ftsA_1 ftsQ_1 ftsQ_1 murG murG murD murD mraY mraY PbpA PbpA ftsL ftsL mraW mraW mraZ mraZ AOM16288.1 AOM16288.1 murA1 murA1 murB murB AOM16430.1 AOM16430.1 AOM16499.1 AOM16499.1 AOM16573.1 AOM16573.1 AOM16574.1 AOM16574.1 AOM16592.1 AOM16592.1 murF murF ddl ddl def def AOM17095.1 AOM17095.1 mreC mreC mreD mreD SagA SagA murE murE AOM17271.1 AOM17271.1 ytgP_2 ytgP_2 rluB rluB Pbp2A Pbp2A AOM17312.1 AOM17312.1 hit hit ecsA_2 ecsA_2 ecsB_2 ecsB_2 AOM17316.1 AOM17316.1 trmB trmB spxA spxA mecA mecA CoiA CoiA AOM17354.1 AOM17354.1 CyaA CyaA RelA RelA ppnK ppnK RluD2 RluD2 mgtE mgtE AOM17413.1 AOM17413.1 spoIIIE spoIIIE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ezrA_2Septation ring formation regulator EzrA; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family. (573 aa)
cwlCCell wall hydrolase; Probably involved in cell-wall metabolism. Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family. (303 aa)
rnhCRibonuclease HIII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (305 aa)
zapACell division protein ZapA; Derived by automated computational analysis using gene prediction method: Protein Homology. (145 aa)
CvpAColicin V production protein CvpA; Derived by automated computational analysis using gene prediction method: Protein Homology. (182 aa)
mutS2DNA mismatch repair protein MutS; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (786 aa)
ecsA_3Sodium ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (299 aa)
traLSodium ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (420 aa)
rpoEDNA-directed RNA polymerase subunit delta; Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; Belongs to the RpoE family. (206 aa)
Pbp1BTransglycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (781 aa)
YneFHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (74 aa)
DacAD-alanyl-D-alanine carboxypeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S11 family. (435 aa)
Pbp2BCell division protein FtsI; Derived by automated computational analysis using gene prediction method: Protein Homology. (717 aa)
AOM15493.1Nucleic acid-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (189 aa)
spxA_1Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ArsC family. (151 aa)
AOM15593.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (348 aa)
AOM15594.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (419 aa)
AOM15595.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0302 family. (193 aa)
AOM15605.1Lipase; Derived by automated computational analysis using gene prediction method: Protein Homology. (298 aa)
AOM15606.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (237 aa)
yozEHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0346 family. (75 aa)
AOM17587.1Peptidase M15; Derived by automated computational analysis using gene prediction method: Protein Homology. (274 aa)
AOM15700.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0223 family. (91 aa)
suhBInositol monophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (255 aa)
typA_1GTP-binding protein TypA; Derived by automated computational analysis using gene prediction method: Protein Homology. (609 aa)
AOM15703.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0358 family. (100 aa)
ftsW_1Cell division protein FtsW; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SEDS family. (387 aa)
AOM15706.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (374 aa)
AOM17590.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0342 family. (145 aa)
AOM15707.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (112 aa)
rsmDSAM-dependent methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (186 aa)
coaDPhosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (163 aa)
ylbLPeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (347 aa)
AOM15776.1Integrase; Derived by automated computational analysis using gene prediction method: Protein Homology. (317 aa)
AmiCN-acetylmuramoyl-L-alanine amidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (295 aa)
ponAPenicillin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (793 aa)
recUHolliday junction endonuclease; Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation; Belongs to the RecU family. (215 aa)
ypsAHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0398 family. (179 aa)
gpsBCell division protein DivIVA; Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation. (139 aa)
prpAPeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (364 aa)
Pbp5Penicillin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (679 aa)
PsrTranscriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (251 aa)
FtsW3Cell division protein FtsW; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SEDS family. (368 aa)
AOM15931.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (57 aa)
ArsC3Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ArsC family. (145 aa)
prsA_1Rotamase; Plays a major role in protein secretion by helping the post- translocational extracellular folding of several secreted proteins. (295 aa)
murCUDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (444 aa)
AOM16068.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (389 aa)
disAHypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (295 aa)
DsbGThioredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (173 aa)
ltaS1_1Phosphoglycerol transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (706 aa)
DivIVACell division protein DivIVA; Derived by automated computational analysis using gene prediction method: Protein Homology. (235 aa)
AOM16275.1RNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (260 aa)
AOM16276.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (73 aa)
sepF_1Cell division protein; Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA. (199 aa)
Alr2Hypothetical protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. (225 aa)
ftsZ_1Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (413 aa)
ftsA_1Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. (441 aa)
ftsQ_1Cell division protein FtsQ; Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex; Belongs to the FtsQ/DivIB family. DivIB subfamily. (406 aa)
murGUDP-diphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (362 aa)
murDUDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (453 aa)
mraYphospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (320 aa)
PbpACell division protein FtsI; Derived by automated computational analysis using gene prediction method: Protein Homology. (730 aa)
ftsLCell division protein; Essential cell division protein; Belongs to the FtsL family. (133 aa)
mraW16S rRNA methyltransferase; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (319 aa)
mraZProtein MraZ; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the MraZ family. (143 aa)
AOM16288.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (122 aa)
murA1UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (423 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (311 aa)
AOM16430.1Alkaline phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (697 aa)
AOM16499.1Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology. (114 aa)
AOM16573.1Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ArsC family. (118 aa)
AOM16574.1Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ArsC family. (136 aa)
AOM16592.1N-acetylmuramoyl-L-alanine amidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (714 aa)
murFUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (450 aa)
ddlD-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (358 aa)
defPeptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (187 aa)
AOM17095.1N-acetylmuramoyl-L-alanine amidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (483 aa)
mreCRod shape-determining protein MreC; Involved in formation and maintenance of cell shape. (284 aa)
mreDRod shape-determining protein MreD; Derived by automated computational analysis using gene prediction method: Protein Homology. (169 aa)
SagAHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (524 aa)
murEUDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Catalyzes the addition of L-lysine to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan; Belongs to the MurCDEF family. MurE subfamily. (501 aa)
AOM17271.1Transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (196 aa)
ytgP_2Polysaccharide biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (548 aa)
rluBPseudouridine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pseudouridine synthase RsuA family. (239 aa)
Pbp2APenicillin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (723 aa)
AOM17312.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (114 aa)
hitHistidine triad protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (144 aa)
ecsA_2Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (245 aa)
ecsB_2Multidrug ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (403 aa)
AOM17316.1Aminoglycoside phosphotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (259 aa)
trmBtRNA (guanine-N7)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (220 aa)
spxAArsR family transcriptional regulator; Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development- promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress. Belongs to the ArsC family. Spx subfamily. (132 aa)
mecACompetence negative regulator MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. (217 aa)
CoiACompetence protein CoiA; Derived by automated computational analysis using gene prediction method: Protein Homology. (332 aa)
AOM17354.1GTP pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (225 aa)
CyaAAdenylate cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (191 aa)
RelAGTP pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (234 aa)
ppnKInorganic polyphosphate kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (265 aa)
RluD2Pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (299 aa)
mgtEMagnesium transporter MgtE; Acts as a magnesium transporter. (453 aa)
AOM17413.1CAAX protease; Derived by automated computational analysis using gene prediction method: Protein Homology. (220 aa)
spoIIIECell division protein FtsK; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FtsK/SpoIIIE/SftA family. (815 aa)
Your Current Organism:
Enterococcus faecium
NCBI taxonomy Id: 1352
Other names: ATCC 19434, CCUG 542, CFBP 4248, CIP 103014, DSM 20477, E. faecium, JCM 5804, JCM 8727, LMG 11423, LMG:11423, NBRC 100485, NBRC 100486, NCDO 942, NCIMB 11508, NCTC 7171, Streptococcus faecium
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