STRINGSTRING
murA1 murA1 spoIIIE spoIIIE murE murE AOM17254.1 AOM17254.1 AOM17227.1 AOM17227.1 AOM17114.1 AOM17114.1 AOM16974.1 AOM16974.1 murF murF AOM16753.1 AOM16753.1 FtsW FtsW murB murB ftsL ftsL PbpA PbpA mraY mraY murD murD murG murG ftsQ_1 ftsQ_1 ftsA_1 ftsA_1 ftsZ_1 ftsZ_1 sepF_1 sepF_1 AOM16276.1 AOM16276.1 DivIVA DivIVA whiA whiA tig tig engB engB murC murC FtsW3 FtsW3 xerC_19 xerC_19 gpsB gpsB ftsW_1 ftsW_1 xerC xerC scpB scpB scpA scpA xerD xerD AOM17580.1 AOM17580.1 ftsX ftsX ftsE ftsE murA murA zapA zapA ezrA_2 ezrA_2 xerS xerS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
murA1UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (423 aa)
spoIIIECell division protein FtsK; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FtsK/SpoIIIE/SftA family. (815 aa)
murEUDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Catalyzes the addition of L-lysine to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan; Belongs to the MurCDEF family. MurE subfamily. (501 aa)
AOM17254.1Muramidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (672 aa)
AOM17227.1Septum formation initiator; Derived by automated computational analysis using gene prediction method: Protein Homology. (141 aa)
AOM17114.1Cell division protein FtsK; Derived by automated computational analysis using gene prediction method: Protein Homology. (446 aa)
AOM16974.1Cell division protein FtsK; Derived by automated computational analysis using gene prediction method: Protein Homology. (473 aa)
murFUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (450 aa)
AOM16753.1Cell division protein FtsK; Derived by automated computational analysis using gene prediction method: Protein Homology. (461 aa)
FtsWCell division protein FtsW; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SEDS family. (395 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (311 aa)
ftsLCell division protein; Essential cell division protein; Belongs to the FtsL family. (133 aa)
PbpACell division protein FtsI; Derived by automated computational analysis using gene prediction method: Protein Homology. (730 aa)
mraYphospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (320 aa)
murDUDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (453 aa)
murGUDP-diphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (362 aa)
ftsQ_1Cell division protein FtsQ; Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex; Belongs to the FtsQ/DivIB family. DivIB subfamily. (406 aa)
ftsA_1Cell division protein FtsA; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. (441 aa)
ftsZ_1Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (413 aa)
sepF_1Cell division protein; Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA. (199 aa)
AOM16276.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (73 aa)
DivIVACell division protein DivIVA; Derived by automated computational analysis using gene prediction method: Protein Homology. (235 aa)
whiASporulation regulator WhiA; Involved in cell division and chromosome segregation. (311 aa)
tigTrigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. (429 aa)
engBGTP-binding protein; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. (195 aa)
murCUDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (444 aa)
FtsW3Cell division protein FtsW; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SEDS family. (368 aa)
xerC_19Integrase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 'phage' integrase family. (343 aa)
gpsBCell division protein DivIVA; Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation. (139 aa)
ftsW_1Cell division protein FtsW; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SEDS family. (387 aa)
xerCRecombinase XerC; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (301 aa)
scpBSegregation and condensation protein B; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves. (189 aa)
scpASegregation and condensation protein A; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves. (265 aa)
xerDRecombinase XerD; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (295 aa)
AOM17580.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (699 aa)
ftsXCell division protein FtsX; Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation. Belongs to the ABC-4 integral membrane protein family. FtsX subfamily. (297 aa)
ftsECell division protein FtsE; Part of the ABC transporter FtsEX involved in cellular division. (228 aa)
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (433 aa)
zapACell division protein ZapA; Derived by automated computational analysis using gene prediction method: Protein Homology. (145 aa)
ezrA_2Septation ring formation regulator EzrA; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family. (573 aa)
xerSRecombinase XerS; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 'phage' integrase family. (361 aa)
Your Current Organism:
Enterococcus faecium
NCBI taxonomy Id: 1352
Other names: ATCC 19434, CCUG 542, CFBP 4248, CIP 103014, DSM 20477, E. faecium, JCM 5804, JCM 8727, LMG 11423, LMG:11423, NBRC 100485, NBRC 100486, NCDO 942, NCIMB 11508, NCTC 7171, Streptococcus faecium
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.