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mleA_1 mleA_1 fbp fbp gap gap pgk pgk tpiA tpiA eno eno AOM15134.1 AOM15134.1 Pgm2 Pgm2 acyP acyP accB accB accC accC accD accD accA_1 accA_1 AOM15481.1 AOM15481.1 pfkA pfkA pyk pyk gnd_1 gnd_1 ulaG ulaG AOM15511.1 AOM15511.1 AOM15512.1 AOM15512.1 SgaB SgaB ulaD ulaD SgbU SgbU araD araD manP_1 manP_1 AOM15546.1 AOM15546.1 PepV2 PepV2 PflB PflB ldhA ldhA pdhA pdhA pdhB pdhB pdhC pdhC lpdA lpdA cfiB cfiB GapA GapA tkt tkt cysK cysK fhs2 fhs2 ldh ldh ulaA_2 ulaA_2 AOM15844.1 AOM15844.1 AOM15891.1 AOM15891.1 ManZ ManZ ManY ManY gnd gnd AOM16009.1 AOM16009.1 gpmA gpmA FruAB FruAB NifJ NifJ gdh_4 gdh_4 phnW phnW phnX phnX arcC arcC glcK glcK PcaC PcaC pgi pgi gdhA gdhA zwf zwf folD folD kbaY kbaY fruA_3 fruA_3 fruA_4 fruA_4 fba fba glnA glnA AOM16382.1 AOM16382.1 eutD eutD AOM16416.1 AOM16416.1 prs2_1 prs2_1 Pck Pck galM galM lysC lysC asd asd dapB dapB dapA dapA dapF dapF lysA lysA cysM_4 cysM_4 galM2 galM2 bsdC bsdC pad1 pad1 AOM16608.1 AOM16608.1 mro mro Fba Fba AOM16668.1 AOM16668.1 ulaB ulaB Fdh Fdh adhE adhE AOM16823.1 AOM16823.1 rpiA_2 rpiA_2 gpmA-2 gpmA-2 glxK_1 glxK_1 xylB xylB cysE cysE prs1 prs1 Rpe Rpe ldh1 ldh1 AOM17289.1 AOM17289.1 ackA_4 ackA_4 araD-2 araD-2 AOM17440.1 AOM17440.1 catE catE glyA glyA mgsA mgsA nrnA_2 nrnA_2 yutF yutF
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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mleA_1Malate dehydrogenase; Malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; Derived by automated computational analysis using gene prediction method: Protein Homology. (546 aa)
fbpClass 3; catalyzes the formation of fructose 6-phosphate from fructose-1,6-bisphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (632 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase; NAD-dependent; catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; active during glycolysis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (333 aa)
pgkPhosphoglycerate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate kinase family. (396 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (432 aa)
AOM15134.1Succinyl-diaminopimelate desuccinylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (379 aa)
Pgm2Phosphoglucomutase; Catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (575 aa)
acyPAcylphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (91 aa)
accBacetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (158 aa)
accCacetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (459 aa)
accDacetyl-CoA carboxylase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (289 aa)
accA_1acetyl-CoA carboxylase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (261 aa)
AOM15481.14-oxalocrotonate tautomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 4-oxalocrotonate tautomerase family. (59 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (320 aa)
pykPyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (594 aa)
gnd_16-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (473 aa)
ulaGAscorbate 6-phosphate lactonase; Derived by automated computational analysis using gene prediction method: Protein Homology. (355 aa)
AOM15511.1PTS ascorbate transporter subunit IIA; Derived by automated computational analysis using gene prediction method: Protein Homology. (153 aa)
AOM15512.1PTS ascorbate transporter subunit IIC; Phosphoenolpyruvate-dependent sugar phosphotransferase system; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; Derived by automated computational analysis using gene prediction method: Protein Homology. (494 aa)
SgaBPTS ascorbate transporter subunit IIB; Derived by automated computational analysis using gene prediction method: Protein Homology. (99 aa)
ulaDCatalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; Derived by automated computational analysis using gene prediction method: Protein Homology. (212 aa)
SgbUXylulose 5-phosphate 3-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (286 aa)
araDCatalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; Derived by automated computational analysis using gene prediction method: Protein Homology. (236 aa)
manP_1PTS mannose transporter subunit IIABC; Phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; Derived by automated computational analysis using gene prediction method: Protein Homology. (646 aa)
AOM15546.1Aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (250 aa)
PepV2Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (446 aa)
PflBFormate acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (743 aa)
ldhALactate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (339 aa)
pdhAPyruvate dehydrogenase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (369 aa)
pdhB2-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (325 aa)
pdhCDihydrolipoamide acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (547 aa)
lpdADihydrolipoamide dehydrogenase; E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: Protein Homology. (468 aa)
cfiBPyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1142 aa)
GapAGlyceraldehyde-3-phosphate dehydrogenase; NAD-dependent; catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; active during glycolysis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
tktTransketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (665 aa)
cysKCysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family. (308 aa)
fhs2Formate--tetrahydrofolate ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the formate--tetrahydrofolate ligase family. (556 aa)
ldhLactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (314 aa)
ulaA_2Glycosidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (457 aa)
AOM15844.1PTS lactose transporter subunit IIB; Derived by automated computational analysis using gene prediction method: Protein Homology. (94 aa)
AOM15891.1Amidase; Catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the amidase family. (483 aa)
ManZPTS mannose transporter subunit IID; Derived by automated computational analysis using gene prediction method: Protein Homology. (285 aa)
ManYPTS sorbose transporter subunit IIC; Derived by automated computational analysis using gene prediction method: Protein Homology. (277 aa)
gnd6-phosphogluconate dehydrogenase; Similar to full-length Gnd, these proteins seems to have a truncated C-terminal 6PGD domainin; in Methylobacillus flagellatus this gene is essential for NAD+-dependent oxidation of 6-phosphogluconate; Derived by automated computational analysis using gene prediction method: Protein Homology. (300 aa)
AOM16009.1enoyl-CoA hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (161 aa)
gpmAPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (222 aa)
FruABPTS fructose transporter subunit IIC; Derived by automated computational analysis using gene prediction method: Protein Homology. (643 aa)
NifJPyruvate-flavodoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1230 aa)
gdh_4Sugar dehydrogenase; Converts glucose to D-glucono-1,5 lactone; Derived by automated computational analysis using gene prediction method: Protein Homology. (261 aa)
phnW2-aminoethylphosphonate:pyruvate aminotransferase; Involved in phosphonate degradation; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily. (363 aa)
phnXPhosphonoacetaldehyde hydrolase; Involved in phosphonate degradation; Belongs to the HAD-like hydrolase superfamily. PhnX family. (181 aa)
arcCCarbamate kinase; Catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; Derived by automated computational analysis using gene prediction method: Protein Homology. (315 aa)
glcKGlucokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (320 aa)
PcaC4-carboxymuconolactone decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (114 aa)
pgiGlucose-6-phosphate isomerase; Functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GPI family. (448 aa)
gdhAGlutamate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (449 aa)
zwfGlucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (508 aa)
folD5,10-methylene-tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa)
kbaYHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (286 aa)
fruA_3PTS fructose transporter subunit IIBC; Derived by automated computational analysis using gene prediction method: Protein Homology. (472 aa)
fruA_4PTS sugar transporter subunit IIA; Derived by automated computational analysis using gene prediction method: Protein Homology. (149 aa)
fbaFructose-bisphosphate aldolase; Catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (289 aa)
glnAGlutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (446 aa)
AOM16382.1Reduces fumarate to succinate in anaerobic bacterial respiration; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (504 aa)
eutDPhosphotransacetylase; In Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; Derived by automated computational analysis using gene prediction method: Protein Homology. (326 aa)
AOM16416.1Glycerate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glycerate kinase type-1 family. (373 aa)
prs2_1Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (324 aa)
PckPhosphoenolpyruvate carboxykinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (545 aa)
galMAldose epimerase; Converts alpha-aldose to the beta-anomer. (343 aa)
lysCAspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (453 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (333 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (238 aa)
dapA4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (266 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (419 aa)
cysM_4Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (305 aa)
galM2Aldose epimerase; Converts alpha-aldose to the beta-anomer. (346 aa)
bsdC3,4-dihydroxybenzoate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UbiD family. (491 aa)
pad13-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (194 aa)
AOM16608.1Amino acid decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (139 aa)
mroAldose epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (335 aa)
FbaIron ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (289 aa)
AOM16668.1PTS ascorbate transporter subunit IIC; Derived by automated computational analysis using gene prediction method: Protein Homology. (429 aa)
ulaBPTS ascorbate transporter subunit IIB; Derived by automated computational analysis using gene prediction method: Protein Homology. (100 aa)
FdhDehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (377 aa)
adhEAcetaldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (865 aa)
AOM16823.1HAD family hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (231 aa)
rpiA_2Ribose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (227 aa)
gpmA-2Phosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (228 aa)
glxK_1Glycerate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glycerate kinase type-1 family. (376 aa)
xylBGluconate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FGGY kinase family. (512 aa)
cysESerine acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (178 aa)
prs1Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (323 aa)
RpeCatalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribulose-phosphate 3-epimerase family. (216 aa)
ldh1Lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (324 aa)
AOM17289.1AP endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (278 aa)
ackA_4Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (394 aa)
araD-2Catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; Derived by automated computational analysis using gene prediction method: Protein Homology. (232 aa)
AOM17440.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (340 aa)
catEGlyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (289 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (414 aa)
mgsAMethylglyoxal synthase; Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. (140 aa)
nrnA_2Oligoribonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (320 aa)
yutFHAD family hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (254 aa)
Your Current Organism:
Enterococcus faecium
NCBI taxonomy Id: 1352
Other names: ATCC 19434, CCUG 542, CFBP 4248, CIP 103014, DSM 20477, E. faecium, JCM 5804, JCM 8727, LMG 11423, LMG:11423, NBRC 100485, NBRC 100486, NCDO 942, NCIMB 11508, NCTC 7171, Streptococcus faecium
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