(51 nodes) Dynein complex, and Dynactin complex network (Caenorhabditis brenneri)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CAEBREN_31719	Uncharacterized protein. (273 aa)
	Cbn-nud-1	CBN-NUD-1 protein. (325 aa)
	lis-1	Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes. Belongs to the WD repeat LIS1/nudF family. (404 aa)
	CAEBREN_22126	zf-C3Hc3H domain-containing protein. (1101 aa)
	CAEBREN_29777	Uncharacterized protein. (303 aa)
	CAEBREN_14231	Uncharacterized protein. (271 aa)
	CAEBREN_17905	Uncharacterized protein. (415 aa)
	CAEBREN_13735	Uncharacterized protein. (1075 aa)
	CAEBREN_00749	DHC_N2 domain-containing protein. (852 aa)
	Cbn-dnc-2	CBN-DNC-2 protein. (327 aa)
	CAEBREN_18054	Uncharacterized protein. (128 aa)
	CAEBREN_28345	Uncharacterized protein. (401 aa)
	CAEBREN_18284	Uncharacterized protein. (123 aa)
	Cbn-dlc-3	Dynein light chain. (132 aa)
	Cbn-cap-2	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (238 aa)
	CAEBREN_14725	WD_REPEATS_REGION domain-containing protein. (273 aa)
	Cbn-ben-1	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
	CAEBREN_12522	Uncharacterized protein. (161 aa)
	CAEBREN_02994	Uncharacterized protein. (478 aa)
	CAEBREN_04893	Uncharacterized protein. (306 aa)
	CAEBREN_25173	Uncharacterized protein. (121 aa)
	CAEBREN_11133	Uncharacterized protein. (106 aa)
	CAEBREN_15757	Dynein light chain roadblock. (95 aa)
	CAEBREN_19893	CAP-Gly domain-containing protein. (1296 aa)
	CAEBREN_31458	Uncharacterized protein; Belongs to the actin family. (361 aa)
	CAEBREN_02627	Dynein light chain. (94 aa)
	CAEBREN_31685	Uncharacterized protein. (370 aa)
	Cbn-dnc-5	CBN-DNC-5 protein. (180 aa)
	CAEBREN_30500	Uncharacterized protein. (1264 aa)
	Cbn-dnc-4	CBN-DNC-4 protein. (413 aa)
	CAEBREN_21570	Uncharacterized protein. (306 aa)
	CAEBREN_00358	CAP-Gly domain-containing protein. (1317 aa)
	Cbn-nud-2	CBN-NUD-2 protein. (303 aa)
	CAEBREN_28751	Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
	CAEBREN_10287	Uncharacterized protein. (102 aa)
	CAEBREN_08068	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (282 aa)
	CAEBREN_12779	Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (441 aa)
	CAEBREN_23444	Uncharacterized protein. (750 aa)
	CAEBREN_20999	Uncharacterized protein. (1126 aa)
	CAEBREN_32350	DHC_N1 domain-containing protein. (995 aa)
	CAEBREN_22899	Dynein light chain. (90 aa)
	CAEBREN_29886	Uncharacterized protein. (2099 aa)
	CAEBREN_30051	Dynein_C domain-containing protein. (318 aa)
	Cbn-dlc-5	CBN-DLC-5 protein. (186 aa)
	CAEBREN_05363	Uncharacterized protein. (647 aa)
	CAEBREN_29846	Uncharacterized protein; Belongs to the actin family. (374 aa)
	CAEBREN_04291	Uncharacterized protein. (215 aa)
	Cbn-bicd-1	CBN-BICD-1 protein. (735 aa)
	CAEBREN_28930	Uncharacterized protein. (2028 aa)
	Cbn-dnc-6	CBN-DNC-6 protein. (174 aa)
	CAEBREN_28895	Uncharacterized protein. (54 aa)

Your Current Organism:

Caenorhabditis brenneri

NCBI taxonomy Id: 135651
Other names: C. brenneri, Caenorhabditis CB5161, Caenorhabditis brenneri Sudhaus & Kiontke, 2007, Caenorhabditis n. sp. CB5161, Caenorhabditis sp. 1 CB5161, Caenorhabditis sp. 4 (CB5161, LKC28, SB129, SB280), Caenorhabditis sp. 4 (CE-II), Caenorhabditis sp. CB5161, Caenorhabditis sp. PB2801

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAEBREN_00358	CAEBREN_00749	G0P6U3	G0ML57	CAP-Gly domain-containing protein.	DHC_N2 domain-containing protein.	0.918
CAEBREN_00358	CAEBREN_02627	G0P6U3	G0NYJ0	CAP-Gly domain-containing protein.	Dynein light chain.	0.782
CAEBREN_00358	CAEBREN_02994	G0P6U3	G0N9A8	CAP-Gly domain-containing protein.	Uncharacterized protein.	0.918
CAEBREN_00358	CAEBREN_04291	G0P6U3	G0PH44	CAP-Gly domain-containing protein.	Uncharacterized protein.	0.924
CAEBREN_00358	CAEBREN_04893	G0P6U3	G0NG64	CAP-Gly domain-containing protein.	Uncharacterized protein.	0.979
CAEBREN_00358	CAEBREN_05363	G0P6U3	G0PCJ5	CAP-Gly domain-containing protein.	Uncharacterized protein.	0.990
CAEBREN_00358	CAEBREN_08068	G0P6U3	G0P7W5	CAP-Gly domain-containing protein.	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.971
CAEBREN_00358	CAEBREN_10287	G0P6U3	G0P7U1	CAP-Gly domain-containing protein.	Uncharacterized protein.	0.826
CAEBREN_00358	CAEBREN_11133	G0P6U3	G0NKH5	CAP-Gly domain-containing protein.	Uncharacterized protein.	0.503
CAEBREN_00358	CAEBREN_12522	G0P6U3	G0N9A7	CAP-Gly domain-containing protein.	Uncharacterized protein.	0.918
CAEBREN_00358	CAEBREN_12779	G0P6U3	G0P8T1	CAP-Gly domain-containing protein.	Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.	0.987
CAEBREN_00358	CAEBREN_13735	G0P6U3	G0ML56	CAP-Gly domain-containing protein.	Uncharacterized protein.	0.918
CAEBREN_00358	CAEBREN_14725	G0P6U3	G0MYN4	CAP-Gly domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.890
CAEBREN_00358	CAEBREN_15757	G0P6U3	G0NNZ5	CAP-Gly domain-containing protein.	Dynein light chain roadblock.	0.801
CAEBREN_00358	CAEBREN_17905	G0P6U3	G0ML53	CAP-Gly domain-containing protein.	Uncharacterized protein.	0.853
CAEBREN_00358	CAEBREN_18054	G0P6U3	G0MLL5	CAP-Gly domain-containing protein.	Uncharacterized protein.	0.991
CAEBREN_00358	CAEBREN_20999	G0P6U3	G0P9D0	CAP-Gly domain-containing protein.	Uncharacterized protein.	0.940
CAEBREN_00358	CAEBREN_21570	G0P6U3	G0P249	CAP-Gly domain-containing protein.	Uncharacterized protein.	0.979
CAEBREN_00358	CAEBREN_22126	G0P6U3	G0MCK5	CAP-Gly domain-containing protein.	zf-C3Hc3H domain-containing protein.	0.969
CAEBREN_00358	CAEBREN_22899	G0P6U3	G0PAE3	CAP-Gly domain-containing protein.	Dynein light chain.	0.782

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