(163 nodes) Longevity regulating pathway - worm network (Caenorhabditis brenneri)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Cbn-hsp-60	CBN-HSP-60 protein; Belongs to the chaperonin (HSP60) family. (567 aa)
	ftt-2	CBN-FTT-2 protein; Belongs to the 14-3-3 family. (248 aa)
	CAEBREN_24408	Uncharacterized protein. (75 aa)
	CAEBREN_02036	VHL domain-containing protein. (177 aa)
	CAEBREN_13113	Fatty acyl-CoA reductase; Catalyzes the reduction of fatty acyl-CoA to fatty alcohols. (536 aa)
	Cbn-jkk-1	CBN-JKK-1 protein. (435 aa)
	CAEBREN_15133	Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
	CAEBREN_16382	Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
	CAEBREN_21541	Uncharacterized protein; Belongs to the cytochrome P450 family. (495 aa)
	CAEBREN_03244	Uncharacterized protein; Belongs to the cytochrome P450 family. (449 aa)
	CAEBREN_08589	Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
	CAEBREN_04660	Uncharacterized protein; Belongs to the cytochrome P450 family. (493 aa)
	Cbn-sod-3	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (223 aa)
	Cbn-cyp-33A1	CBN-CYP-33A1 protein; Belongs to the cytochrome P450 family. (493 aa)
	Cbn-nhr-48	CBN-NHR-48 protein. (860 aa)
	Cbn-atf-5	CBN-ATF-5 protein. (275 aa)
	CAEBREN_01773	Uncharacterized protein. (292 aa)
	CAEBREN_22109	Uncharacterized protein. (287 aa)
	CAEBREN_10846	Uncharacterized protein. (165 aa)
	CAEBREN_01518	Uncharacterized protein. (113 aa)
	CAEBREN_12387	Uncharacterized protein; Belongs to the GST superfamily. (255 aa)
	CAEBREN_31196	Uncharacterized protein; Belongs to the GST superfamily. (250 aa)
	CAEBREN_05553	Uncharacterized protein; Belongs to the protein kinase superfamily. (381 aa)
	Cbn-gst-36	CBN-GST-36 protein. (210 aa)
	CAEBREN_31767	Uncharacterized protein. (741 aa)
	Cbn-sip-1	CBN-SIP-1 protein; Belongs to the small heat shock protein (HSP20) family. (162 aa)
	CAEBREN_17786	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (535 aa)
	CAEBREN_26095	Nuclear receptor domain-containing protein. (442 aa)
	CAEBREN_02271	VHL domain-containing protein. (170 aa)
	Cbn-pme-2	Poly [ADP-ribose] polymerase. (519 aa)
	CAEBREN_08009	Uncharacterized protein; Belongs to the GST superfamily. (206 aa)
	CAEBREN_14956	Uncharacterized protein; Belongs to the GST superfamily. (209 aa)
	CAEBREN_12715	Uncharacterized protein; Belongs to the GST superfamily. (209 aa)
	CAEBREN_04473	Uncharacterized protein. (209 aa)
	CAEBREN_19495	Uncharacterized protein. (210 aa)
	CAEBREN_01610	Uncharacterized protein. (207 aa)
	CAEBREN_18794	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (511 aa)
	Cbn-ctl-2	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (500 aa)
	CAEBREN_17928	Uncharacterized protein; Belongs to the cytochrome P450 family. (491 aa)
	Cbn-haf-1	CBN-HAF-1 protein. (677 aa)
	CAEBREN_31247	Uncharacterized protein. (526 aa)
	Cbn-daf-9	CBN-DAF-9 protein; Belongs to the cytochrome P450 family. (533 aa)
	CAEBREN_11387	Uncharacterized protein; Belongs to the heat shock protein 70 family. (661 aa)
	Cbn-age-1	CBN-AGE-1 protein; Belongs to the PI3/PI4-kinase family. (1144 aa)
	Cbn-sek-1	CBN-SEK-1 protein; Belongs to the protein kinase superfamily. (341 aa)
	Cbn-lipl-4	Lipase; Belongs to the AB hydrolase superfamily. Lipase family. (409 aa)
	Cbn-gsto-3	CBN-GSTO-3 protein; Belongs to the GST superfamily. (323 aa)
	CAEBREN_19906	Uncharacterized protein. (496 aa)
	CAEBREN_20003	Uncharacterized protein. (112 aa)
	lgg-2	Protein lgg. (123 aa)
	Cbn-fat-5	CBN-FAT-5 protein; Belongs to the fatty acid desaturase type 1 family. (333 aa)
	CAEBREN_06907	Protein kinase domain-containing protein. (770 aa)
	Cbn-unc-51	CBN-UNC-51 protein. (858 aa)
	Cbn-gst-38	CBN-GST-38 protein; Belongs to the GST superfamily. (209 aa)
	Cbn-cyp-33D1	CBN-CYP-33D1 protein; Belongs to the cytochrome P450 family. (490 aa)
	Cbn-lips-10	CBN-LIPS-10 protein. (276 aa)
	CAEBREN_09882	Uncharacterized protein. (1077 aa)
	Cbn-hsb-1	CBN-HSB-1 protein. (81 aa)
	CAEBREN_06303	DUF148 domain-containing protein. (146 aa)
	CAEBREN_08229	Uncharacterized protein. (1851 aa)
	CAEBREN_23036	Uncharacterized protein. (477 aa)
	CAEBREN_25185	Non-specific serine/threonine protein kinase. (548 aa)
	Cbn-daf-36	CBN-DAF-36 protein. (148 aa)
	CAEBREN_14940	Uncharacterized protein. (284 aa)
	Cbn-tcer-1	CBN-TCER-1 protein. (900 aa)
	CAEBREN_16101	Uncharacterized protein. (93 aa)
	CAEBREN_30310	Uncharacterized protein. (365 aa)
	CAEBREN_29878	BZIP domain-containing protein. (257 aa)
	CAEBREN_01873	Uncharacterized protein. (425 aa)
	Cbn-ddl-1	CBN-DDL-1 protein. (163 aa)
	Cbn-cyp-33C11	CBN-CYP-33C11 protein; Belongs to the cytochrome P450 family. (494 aa)
	Cbn-cyp-33C9	CBN-CYP-33C9 protein. (496 aa)
	CAEBREN_18724	Uncharacterized protein; Belongs to the cytochrome P450 family. (424 aa)
	CAEBREN_16505	Uncharacterized protein. (219 aa)
	Cbn-hcf-1	CBN-HCF-1 protein. (775 aa)
	CAEBREN_18517	Uncharacterized protein; Belongs to the GST superfamily. (267 aa)
	CAEBREN_07990	Fork-head domain-containing protein. (483 aa)
	CAEBREN_03943	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2185 aa)
	CAEBREN_16508	Uncharacterized protein. (242 aa)
	CAEBREN_28470	Fork-head domain-containing protein. (441 aa)
	Cbn-hif-1	CBN-HIF-1 protein. (732 aa)
	Cbn-kri-1	CBN-KRI-1 protein. (540 aa)
	Cbn-clpp-1	ATP-dependent Clp protease proteolytic subunit. (223 aa)
	Cbn-sir-2.1	CBN-SIR-2.1 protein. (611 aa)
	CAEBREN_05620	Protein kinase domain-containing protein. (405 aa)
	Cbn-pme-1	Poly [ADP-ribose] polymerase. (403 aa)
	CAEBREN_17492	SMK-1 domain-containing protein. (1171 aa)
	Cbn-gcs-1	CBN-GCS-1 protein. (654 aa)
	CAEBREN_14274	Deacetylase sirtuin-type domain-containing protein. (612 aa)
	CAEBREN_05283	Protein kinase domain-containing protein. (386 aa)
	CAEBREN_01299	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (144 aa)
	CAEBREN_02236	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (143 aa)
	CAEBREN_31267	Uncharacterized protein; Belongs to the cytochrome P450 family. (505 aa)
	CAEBREN_28282	Uncharacterized protein; Belongs to the fatty acid desaturase type 1 family. (340 aa)
	Cbn-par-5	CBN-PAR-5 protein; Belongs to the 14-3-3 family. (248 aa)
	CAEBREN_05836	Fork-head domain-containing protein. (717 aa)
	CAEBREN_21581	HSF_DOMAIN domain-containing protein. (688 aa)
	CAEBREN_15511	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (143 aa)
	CAEBREN_12489	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (143 aa)
	CAEBREN_16878	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (143 aa)
	Cbn-daf-18	CBN-DAF-18 protein. (683 aa)
	CAEBREN_32002	Mitogen-activated protein kinase. (391 aa)
	CAEBREN_29500	Uncharacterized protein. (346 aa)
	CAEBREN_30969	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (221 aa)
	CAEBREN_08904	Nuclear receptor domain-containing protein. (260 aa)
	Cbn-daf-12	CBN-DAF-12 protein. (131 aa)
	CAEBREN_09109	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (221 aa)
	CAEBREN_07464	Uncharacterized protein; Belongs to the GST superfamily. (212 aa)
	CAEBREN_20287	Uncharacterized protein; Belongs to the GST superfamily. (212 aa)
	CAEBREN_31931	Poly [ADP-ribose] polymerase. (915 aa)
	CAEBREN_31755	Uncharacterized protein. (765 aa)
	CAEBREN_00923	Uncharacterized protein. (473 aa)
	CAEBREN_21266	Uncharacterized protein; Belongs to the protein kinase superfamily. (347 aa)
	CAEBREN_19756	DUF148 domain-containing protein. (250 aa)
	CAEBREN_23166	DUF148 domain-containing protein. (250 aa)
	CAEBREN_28114	Uncharacterized protein. (560 aa)
	CAEBREN_30412	Protein kinase domain-containing protein. (324 aa)
	CAEBREN_30533	Protein kinase domain-containing protein. (355 aa)
	CAEBREN_13046	Mitogen-activated protein kinase. (463 aa)
	CAEBREN_05268	BZIP domain-containing protein. (864 aa)
	CAEBREN_32554	Uncharacterized protein; Belongs to the GST superfamily. (207 aa)
	CAEBREN_16021	Uncharacterized protein. (210 aa)
	CAEBREN_15403	Uncharacterized protein. (209 aa)
	CAEBREN_14802	Uncharacterized protein; Belongs to the GST superfamily. (209 aa)
	CAEBREN_02173	Uncharacterized protein. (112 aa)
	CAEBREN_11365	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (511 aa)
	Cbn-lips-6	CBN-LIPS-6 protein. (385 aa)
	CAEBREN_08726	Uncharacterized protein; Belongs to the fatty acid desaturase type 1 family. (340 aa)
	CAEBREN_11357	Uncharacterized protein. (350 aa)
	CAEBREN_05079	Uncharacterized protein; Belongs to the cytochrome P450 family. (128 aa)
	Cbn-pmk-1	Mitogen-activated protein kinase. (380 aa)
	CAEBREN_25322	Mitogen-activated protein kinase. (367 aa)
	Cbn-pmk-3	Mitogen-activated protein kinase. (469 aa)
	CAEBREN_30336	ANK_REP_REGION domain-containing protein. (541 aa)
	Cbn-daf-2	CBN-DAF-2 protein. (1937 aa)
	CAEBREN_31240	Uncharacterized protein; Belongs to the cytochrome P450 family. (495 aa)
	CAEBREN_15833	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (110 aa)
	CAEBREN_16327	Uncharacterized protein. (206 aa)
	CAEBREN_05754	Uncharacterized protein. (95 aa)
	CAEBREN_00335	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (110 aa)
	Cbn-zip-3	CBN-ZIP-3 protein. (320 aa)
	CAEBREN_02840	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (227 aa)
	CAEBREN_30586	Uncharacterized protein; Belongs to the cytochrome P450 family. (483 aa)
	CAEBREN_29191	SMK-1 domain-containing protein. (1206 aa)
	CAEBREN_25208	WH2 domain-containing protein. (513 aa)
	CAEBREN_02175	Uncharacterized protein; Belongs to the cytochrome P450 family. (395 aa)
	CAEBREN_03470	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1178 aa)
	CAEBREN_17512	Uncharacterized protein; Belongs to the heat shock protein 70 family. (657 aa)
	CAEBREN_29358	Uncharacterized protein. (727 aa)
	CAEBREN_30807	Poly [ADP-ribose] polymerase. (272 aa)
	Cbn-lips-17	CBN-LIPS-17 protein. (257 aa)
	CAEBREN_21207	Uncharacterized protein. (614 aa)
	CAEBREN_05314	DUF148 domain-containing protein. (434 aa)
	CAEBREN_31526	Poly [ADP-ribose] polymerase. (524 aa)
	CAEBREN_03353	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (144 aa)
	CAEBREN_10775	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family. (143 aa)
	CAEBREN_19684	Uncharacterized protein; Belongs to the GST superfamily. (218 aa)
	CAEBREN_16817	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (511 aa)
	CAEBREN_28957	WW domain-containing protein. (318 aa)
	CAEBREN_31872	Uncharacterized protein; Belongs to the cytochrome P450 family. (300 aa)
	CAEBREN_32734	Uncharacterized protein. (499 aa)
	CAEBREN_31217	Uncharacterized protein; Belongs to the cytochrome P450 family. (513 aa)
	Cbn-ubl-5	CBN-UBL-5 protein. (73 aa)

Your Current Organism:

Caenorhabditis brenneri

NCBI taxonomy Id: 135651
Other names: C. brenneri, Caenorhabditis CB5161, Caenorhabditis brenneri Sudhaus & Kiontke, 2007, Caenorhabditis n. sp. CB5161, Caenorhabditis sp. 1 CB5161, Caenorhabditis sp. 4 (CB5161, LKC28, SB129, SB280), Caenorhabditis sp. 4 (CE-II), Caenorhabditis sp. CB5161, Caenorhabditis sp. PB2801

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAEBREN_00335	CAEBREN_01299	G0PEQ0	G0NU08	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family.	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family.	0.931
CAEBREN_00335	CAEBREN_01873	G0PEQ0	G0NAN1	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family.	Uncharacterized protein.	0.674
CAEBREN_00335	CAEBREN_02236	G0PEQ0	G0NU10	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family.	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family.	0.801
CAEBREN_00335	CAEBREN_03353	G0PEQ0	G0PMB1	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family.	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family.	0.930
CAEBREN_00335	CAEBREN_05836	G0PEQ0	G0NVG7	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family.	Fork-head domain-containing protein.	0.569
CAEBREN_00335	CAEBREN_07990	G0PEQ0	G0NH75	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family.	Fork-head domain-containing protein.	0.569
CAEBREN_00335	CAEBREN_08229	G0PEQ0	G0N858	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family.	Uncharacterized protein.	0.625
CAEBREN_00335	CAEBREN_09109	G0PEQ0	G0P080	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family.	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	0.495
CAEBREN_00335	CAEBREN_10775	G0PEQ0	G0PMB3	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family.	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family.	0.801
CAEBREN_00335	CAEBREN_11387	G0PEQ0	G0MTS9	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.571
CAEBREN_00335	CAEBREN_12489	G0PEQ0	G0NWU0	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family.	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family.	0.802
CAEBREN_00335	CAEBREN_15511	G0PEQ0	G0NWT7	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family.	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family.	0.801
CAEBREN_00335	CAEBREN_16878	G0PEQ0	G0NWU3	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family.	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family.	0.806
CAEBREN_00335	CAEBREN_17512	G0PEQ0	G0PJ01	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.571
CAEBREN_00335	CAEBREN_21581	G0PEQ0	G0NVM9	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family.	HSF_DOMAIN domain-containing protein.	0.834
CAEBREN_00335	CAEBREN_24408	G0PEQ0	B6VBJ7	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family.	Uncharacterized protein.	0.576
CAEBREN_00335	CAEBREN_25322	G0PEQ0	G0PBC0	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family.	Mitogen-activated protein kinase.	0.407
CAEBREN_00335	CAEBREN_28470	G0PEQ0	G0NKL6	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family.	Fork-head domain-containing protein.	0.464
CAEBREN_00335	CAEBREN_30969	G0PEQ0	G0NZF8	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family.	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	0.495
CAEBREN_00335	Cbn-daf-2	G0PEQ0	G0PDK2	SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family.	CBN-DAF-2 protein.	0.625

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