90 items (Zootermopsis nevadensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	L798_07051	DNA replication licensing factor MCM8; Belongs to the MCM family. (833 aa)
	L798_02092	Replication factor C subunit 4. (361 aa)
	L798_06593	Checkpoint protein; Belongs to the HUS1 family. (279 aa)
	L798_08700	DNA replication licensing factor MCM9; Belongs to the MCM family. (1000 aa)
	L798_12384	Ankyrin repeat domain-containing protein 11. (744 aa)
	L798_07907	Piezo_RRas_bdg domain-containing protein. (821 aa)
	L798_00096	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
	L798_14167	Craniofacial development protein 2. (140 aa)
	L798_05101	Craniofacial development protein 2. (227 aa)
	L798_07584	E3 ubiquitin-protein ligase RNF8 A. (542 aa)
	L798_13237	Uncharacterized protein. (117 aa)
	L798_01187	Uncharacterized protein. (116 aa)
	L798_02831	Replication factor C subunit 2. (364 aa)
	L798_11187	Uncharacterized protein. (115 aa)
	L798_14995	Ubiquitin. (230 aa)
	L798_11781	Tumor suppressor p53-binding protein 1. (1553 aa)
	L798_10718	14-3-3 protein zeta; Belongs to the 14-3-3 family. (303 aa)
	L798_14458	Uncharacterized protein. (141 aa)
	L798_15284	Proteasome activator complex subunit 4. (1833 aa)
	L798_09937	Uncharacterized protein. (149 aa)
	L798_13806	DNA topoisomerase 2-binding protein 1. (1298 aa)
	L798_13508	G2/mitotic-specific cyclin-B; Belongs to the cyclin family. (388 aa)
	L798_09558	DNA helicase; Belongs to the MCM family. (936 aa)
	L798_09068	Uncharacterized protein. (145 aa)
	L798_09289	DNA helicase; Belongs to the MCM family. (887 aa)
	L798_08302	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (1393 aa)
	L798_08319	Uncharacterized protein. (174 aa)
	L798_13901	Cell division control protein 2-like protein; Belongs to the protein kinase superfamily. (299 aa)
	L798_08031	Cell division protein kinase 2; Belongs to the protein kinase superfamily. (268 aa)
	L798_07743	Replication factor C subunit 5. (334 aa)
	L798_08005	BRCA1-A complex subunit MERIT40. (332 aa)
	L798_07447	KxDL domain-containing protein. (222 aa)
	L798_12216	Lys-63-specific deubiquitinase BRCC36. (107 aa)
	L798_06657	Uncharacterized protein. (172 aa)
	L798_10699	DNA helicase; Belongs to the MCM family. (861 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
	L798_07450	Origin recognition complex subunit 6. (252 aa)
	L798_09841	Uncharacterized protein. (139 aa)
	L798_09593	Replication protein A 14 kDa subunit. (116 aa)
	L798_10234	CDC45-related protein. (572 aa)
	L798_10145	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (358 aa)
	L798_10599	Membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase. (550 aa)
	L798_09441	MCM10-like protein. (750 aa)
	L798_04854	Origin recognition complex subunit 2. (492 aa)
	L798_10442	Uncharacterized protein. (468 aa)
	L798_01129	Cell cycle checkpoint control protein; Belongs to the rad9 family. (428 aa)
	L798_08397	RCC1 and BTB domain-containing protein 1. (532 aa)
	L798_08301	Uncharacterized protein. (598 aa)
	L798_04236	Cell division cycle-associated 7-like protein. (293 aa)
	L798_10144	Uncharacterized protein. (100 aa)
	L798_03342	Cell cycle checkpoint protein RAD17. (616 aa)
	L798_04486	Uncharacterized protein. (761 aa)
	L798_00484	Uncharacterized protein. (161 aa)
	L798_04103	Tudor domain-containing protein 3. (816 aa)
	L798_08300	Uncharacterized protein. (118 aa)
	L798_03144	Breast cancer type 1 susceptibility protein-like protein. (650 aa)
	L798_01172	Putative E3 ubiquitin-protein ligase HERC2. (1940 aa)
	L798_07380	DNA helicase; Belongs to the MCM family. (814 aa)
	L798_05836	E3 ubiquitin-protein ligase RNF168. (653 aa)
	L798_02644	Exonuclease 3'-5' domain-containing protein 2. (607 aa)
	L798_14236	Origin recognition complex subunit 3. (661 aa)
	L798_04179	BRCA1-A complex subunit BRE. (388 aa)
	L798_12864	Wee1-like protein kinase. (575 aa)
	L798_07611	Serine/threonine-protein kinase grp. (503 aa)
	L798_13571	Protein chiffon. (1438 aa)
	L798_14749	Replication factor C subunit 3. (333 aa)
	L798_12186	Uncharacterized protein. (165 aa)
	L798_02501	E3 ubiquitin-protein ligase RNF8. (97 aa)
	L798_14792	Uncharacterized protein. (164 aa)
	L798_13600	Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (434 aa)
	L798_12043	G2/mitotic-specific cyclin-B3; Belongs to the cyclin family. (488 aa)
	L798_12338	Cell division cycle 7-related protein kinase. (688 aa)
	L798_11449	Uncharacterized protein. (161 aa)
	L798_01850	Ubiquitin. (229 aa)
	L798_12215	Lys-63-specific deubiquitinase BRCC36. (263 aa)
	L798_13361	Uncharacterized protein. (128 aa)
	L798_05606	Serine/threonine-protein kinase Chk2. (456 aa)
	L798_02126	E3 ubiquitin-protein ligase RNF8. (254 aa)
	L798_01313	Cell division control protein 6-like protein. (428 aa)
	L798_15108	Uncharacterized protein. (160 aa)
	L798_01925	RecQ-mediated genome instability protein 1. (686 aa)
	L798_00977	ATP-dependent DNA helicase Q4. (1386 aa)
	L798_01150	M-phase inducer phosphatase. (358 aa)
	L798_15720	DNA helicase; Belongs to the MCM family. (732 aa)
	L798_15277	Claspin. (1288 aa)
	L798_03122	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
	L798_13865	Uncharacterized protein. (106 aa)
	L798_13903	Cell cycle checkpoint protein RAD1. (274 aa)
	L798_14617	Uncharacterized protein. (1163 aa)
	L798_14842	Origin recognition complex subunit 5. (447 aa)

Your Current Organism:

Zootermopsis nevadensis

NCBI taxonomy Id: 136037
Other names: Z. nevadensis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
L798_00096	L798_00977	A0A067RKT9	A0A067QLC4	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	ATP-dependent DNA helicase Q4.	0.932
L798_00096	L798_01129	A0A067RKT9	A0A067RBB5	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Cell cycle checkpoint control protein; Belongs to the rad9 family.	0.919
L798_00096	L798_01313	A0A067RKT9	A0A067QJI7	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Cell division control protein 6-like protein.	0.654
L798_00096	L798_01850	A0A067RKT9	A0A067QVQ6	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Ubiquitin.	0.403
L798_00096	L798_01925	A0A067RKT9	A0A067QK69	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	RecQ-mediated genome instability protein 1.	0.965
L798_00096	L798_02092	A0A067RKT9	A0A067RGL1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Replication factor C subunit 4.	0.792
L798_00096	L798_02644	A0A067RKT9	A0A067QRJ3	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Exonuclease 3'-5' domain-containing protein 2.	0.716
L798_00096	L798_02831	A0A067RKT9	A0A067RQC0	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Replication factor C subunit 2.	0.777
L798_00096	L798_03122	A0A067RKT9	A0A067QQ31	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.476
L798_00096	L798_03144	A0A067RKT9	A0A067REA2	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Breast cancer type 1 susceptibility protein-like protein.	0.721
L798_00096	L798_03342	A0A067RKT9	A0A067RD43	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Cell cycle checkpoint protein RAD17.	0.861
L798_00096	L798_04103	A0A067RKT9	A0A067RDU6	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Tudor domain-containing protein 3.	0.654
L798_00096	L798_04236	A0A067RKT9	A0A067RC17	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Cell division cycle-associated 7-like protein.	0.732
L798_00096	L798_04486	A0A067RKT9	A0A067RD52	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Uncharacterized protein.	0.695
L798_00096	L798_04854	A0A067RKT9	A0A067RAK7	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Origin recognition complex subunit 2.	0.748
L798_00096	L798_06593	A0A067RKT9	A0A067RHI8	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Checkpoint protein; Belongs to the HUS1 family.	0.750
L798_00096	L798_07051	A0A067RKT9	A0A067RG02	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA replication licensing factor MCM8; Belongs to the MCM family.	0.597
L798_00096	L798_07380	A0A067RKT9	A0A067RF20	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	DNA helicase; Belongs to the MCM family.	0.876
L798_00096	L798_07450	A0A067RKT9	A0A067R7J3	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Origin recognition complex subunit 6.	0.606
L798_00096	L798_07611	A0A067RKT9	A0A067RWE0	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	Serine/threonine-protein kinase grp.	0.727