STRINGSTRING
PDGFD PDGFD PRDM4 PRDM4 PDGFC PDGFC IGF1 IGF1 VEGFC VEGFC FGF16 FGF16 FGF19 FGF19 FGF4 FGF4 TEK TEK FGFRL1 FGFRL1 NGF NGF ANGPT1 ANGPT1 FGF11 FGF11 FGFR2 FGFR2 FLT1 FLT1 IGFBP3 IGFBP3 PDGFB PDGFB FGF17 FGF17 CSF1R CSF1R FGFR1 FGFR1 TIE1 TIE1 TGFA TGFA ANGPT2 ANGPT2 NTF4 NTF4 IL34 IL34 NTRK1 NTRK1 VEGFD VEGFD CCN2 CCN2 FGF23 FGF23 FGF2 FGF2 VEGFA VEGFA FGF20 FGF20 KLB KLB PDGFRA PDGFRA KDR KDR FGF5 FGF5 LOC100017469 LOC100017469 CSF1 CSF1 NTRK3 NTRK3 NTRK2 NTRK2 KIT KIT F6WCI6_MONDO F6WCI6_MONDO EGF EGF NGFR NGFR FGF3 FGF3 FGFR4 FGFR4 KITLG KITLG BDNF BDNF PDGFA PDGFA FLT4 FLT4 ENSMODP00000047413 ENSMODP00000047413 ENSMODP00000048105 ENSMODP00000048105 PGF PGF SH2B3 SH2B3 FGF1 FGF1 ANGPT4 ANGPT4 FGF6 FGF6 FGFR3 FGFR3 FGF8 FGF8 FGF10 FGF10 FGF18 FGF18 FGF7 FGF7 NTF3 NTF3 VEGFB VEGFB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDGFDPlatelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (370 aa)
PRDM4PR/SET domain 4. (833 aa)
PDGFCPlatelet derived growth factor C. (345 aa)
IGF1Insulin like growth factor 1. (225 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (351 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (212 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (192 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
FGFRL1Fibroblast growth factor receptor like 1. (494 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (238 aa)
ANGPT1Angiopoietin 1. (498 aa)
FGF11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (225 aa)
FGFR2Fibroblast growth factor receptor. (839 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1341 aa)
IGFBP3Insulin like growth factor binding protein 3. (283 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (235 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (959 aa)
FGFR1Fibroblast growth factor receptor. (809 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa)
TGFATransforming growth factor alpha. (159 aa)
ANGPT2Angiopoietin 2. (495 aa)
NTF4Neurotrophin 4; Belongs to the NGF-beta family. (249 aa)
IL34Uncharacterized protein. (279 aa)
NTRK1Tyrosine-protein kinase receptor. (739 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (353 aa)
CCN2Cellular communication network factor 2. (351 aa)
FGF23Fibroblast growth factor 23. (193 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (156 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (445 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
KLBKlotho beta. (1018 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1085 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1349 aa)
FGF5Uncharacterized protein. (125 aa)
LOC100017469Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1570 aa)
CSF1Uncharacterized protein. (340 aa)
NTRK3Tyrosine-protein kinase receptor. (850 aa)
NTRK2Tyrosine-protein kinase receptor. (750 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (967 aa)
F6WCI6_MONDOUncharacterized protein; Belongs to the glycosyl hydrolase 1 family. (301 aa)
EGFEpidermal growth factor. (1143 aa)
NGFRNerve growth factor receptor. (433 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (254 aa)
FGFR4Fibroblast growth factor receptor. (849 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (285 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (211 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1337 aa)
ENSMODP00000047413Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (226 aa)
ENSMODP00000048105Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family. (343 aa)
PGFPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (207 aa)
SH2B3SH2 domain-containing protein. (458 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (181 aa)
ANGPT4Angiopoietin 4. (495 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
FGFR3Fibroblast growth factor receptor. (729 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (229 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (223 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (212 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (343 aa)
VEGFBPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (568 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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