(14 nodes) Gamma-secretase complex, and E2 domain superfamily network (Monodelphis domestica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CNTN5	Contactin 5. (1027 aa)
	PSENEN	Uncharacterized protein. (101 aa)
	APBB1	Amyloid beta precursor protein binding family B member 1. (711 aa)
	TNFRSF21	TNF receptor superfamily member 21. (671 aa)
	APLP1	Amyloid beta precursor like protein 1. (581 aa)
	APH1A	Aph-1 homolog A, gamma-secretase subunit. (265 aa)
	APBB2	Amyloid beta precursor protein binding family B member 2. (769 aa)
	APP	Amyloid beta precursor protein. (717 aa)
	NCSTN	Nicastrin. (790 aa)
	APLP2	Amyloid beta precursor like protein 2. (714 aa)
	PSEN2	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (466 aa)
	APH1B	Aph-1 homolog B, gamma-secretase subunit. (211 aa)
	ENSMODP00000056779	BPTI/Kunitz inhibitor domain-containing protein. (65 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (516 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APBB1	APBB2	ENSMODP00000023186	ENSMODP00000042322	Amyloid beta precursor protein binding family B member 1.	Amyloid beta precursor protein binding family B member 2.	0.564
APBB1	APLP1	ENSMODP00000023186	ENSMODP00000031535	Amyloid beta precursor protein binding family B member 1.	Amyloid beta precursor like protein 1.	0.800
APBB1	APLP2	ENSMODP00000023186	ENSMODP00000044572	Amyloid beta precursor protein binding family B member 1.	Amyloid beta precursor like protein 2.	0.797
APBB1	APP	ENSMODP00000023186	ENSMODP00000043145	Amyloid beta precursor protein binding family B member 1.	Amyloid beta precursor protein.	0.981
APBB2	APBB1	ENSMODP00000042322	ENSMODP00000023186	Amyloid beta precursor protein binding family B member 2.	Amyloid beta precursor protein binding family B member 1.	0.564
APBB2	APLP1	ENSMODP00000042322	ENSMODP00000031535	Amyloid beta precursor protein binding family B member 2.	Amyloid beta precursor like protein 1.	0.661
APBB2	APLP2	ENSMODP00000042322	ENSMODP00000044572	Amyloid beta precursor protein binding family B member 2.	Amyloid beta precursor like protein 2.	0.605
APBB2	APP	ENSMODP00000042322	ENSMODP00000043145	Amyloid beta precursor protein binding family B member 2.	Amyloid beta precursor protein.	0.941
APH1A	APH1B	ENSMODP00000041564	ENSMODP00000050728	Aph-1 homolog A, gamma-secretase subunit.	Aph-1 homolog B, gamma-secretase subunit.	0.903
APH1A	APLP2	ENSMODP00000041564	ENSMODP00000044572	Aph-1 homolog A, gamma-secretase subunit.	Amyloid beta precursor like protein 2.	0.402
APH1A	APP	ENSMODP00000041564	ENSMODP00000043145	Aph-1 homolog A, gamma-secretase subunit.	Amyloid beta precursor protein.	0.570
APH1A	NCSTN	ENSMODP00000041564	ENSMODP00000043878	Aph-1 homolog A, gamma-secretase subunit.	Nicastrin.	0.992
APH1A	PSEN1	ENSMODP00000041564	ENSMODP00000057945	Aph-1 homolog A, gamma-secretase subunit.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.982
APH1A	PSEN2	ENSMODP00000041564	ENSMODP00000045389	Aph-1 homolog A, gamma-secretase subunit.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.980
APH1A	PSENEN	ENSMODP00000041564	ENSMODP00000017517	Aph-1 homolog A, gamma-secretase subunit.	Uncharacterized protein.	0.990
APH1B	APH1A	ENSMODP00000050728	ENSMODP00000041564	Aph-1 homolog B, gamma-secretase subunit.	Aph-1 homolog A, gamma-secretase subunit.	0.903
APH1B	APLP2	ENSMODP00000050728	ENSMODP00000044572	Aph-1 homolog B, gamma-secretase subunit.	Amyloid beta precursor like protein 2.	0.402
APH1B	APP	ENSMODP00000050728	ENSMODP00000043145	Aph-1 homolog B, gamma-secretase subunit.	Amyloid beta precursor protein.	0.570
APH1B	NCSTN	ENSMODP00000050728	ENSMODP00000043878	Aph-1 homolog B, gamma-secretase subunit.	Nicastrin.	0.992
APH1B	PSEN1	ENSMODP00000050728	ENSMODP00000057945	Aph-1 homolog B, gamma-secretase subunit.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.982