(33 nodes) JAK-STAT signaling pathway network (Monodelphis domestica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IL2RB	Fibronectin type-III domain-containing protein. (562 aa)
	IL23R	Uncharacterized protein. (604 aa)
	JAK1	Protein kinase domain-containing protein. (199 aa)
	IL10	Interleukin 10. (173 aa)
	IFN3	Uncharacterized protein. (184 aa)
	LOC100021419	Type I interferon 5. (184 aa)
	IFNK	Type I interferon 9. (202 aa)
	IL13RA2	Uncharacterized protein. (400 aa)
	IL2RG	Fibronectin type-III domain-containing protein. (301 aa)
	TYK2	Tyrosine-protein kinase. (1193 aa)
	IL22	Uncharacterized protein. (173 aa)
	IL17D	Interleukin 17D. (210 aa)
	IL13RA1	Interleukin 13 receptor subunit alpha 1. (423 aa)
	IL22RA1	Fibronectin type-III domain-containing protein. (633 aa)
	IFNLR1	Fibronectin type-III domain-containing protein. (524 aa)
	IL10RA	Fibronectin type-III domain-containing protein. (605 aa)
	IL7R	Fibronectin type-III domain-containing protein. (456 aa)
	IFNGR2	Uncharacterized protein. (344 aa)
	IFNAR1	Uncharacterized protein. (565 aa)
	IL10RB	Interleukin 10 receptor subunit beta. (330 aa)
	JAK3	Tyrosine-protein kinase. (1097 aa)
	K7E4W0_MONDO	Fibronectin type-III domain-containing protein. (529 aa)
	CRLF2	Uncharacterized protein. (369 aa)
	IL9	Uncharacterized protein. (167 aa)
	IL4R	IL4Ra_N domain-containing protein. (930 aa)
	IL15	Interleukin; Belongs to the IL-15/IL-21 family. (183 aa)
	IFNAR2	Uncharacterized protein. (511 aa)
	IL7	Uncharacterized protein. (205 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (142 aa)
	IFN4	Type I interferon 4. (183 aa)
	IFNGR1	Fibronectin type-III domain-containing protein. (503 aa)
	IL15RA	Sushi domain-containing protein. (295 aa)
	IFN2	Type I interferon 2. (183 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRLF2	IFN2	ENSMODP00000041017	ENSMODP00000059244	Uncharacterized protein.	Type I interferon 2.	0.650
CRLF2	IFN3	ENSMODP00000041017	ENSMODP00000004490	Uncharacterized protein.	Uncharacterized protein.	0.650
CRLF2	IFN4	ENSMODP00000041017	ENSMODP00000054966	Uncharacterized protein.	Type I interferon 4.	0.650
CRLF2	IFNK	ENSMODP00000041017	ENSMODP00000005303	Uncharacterized protein.	Type I interferon 9.	0.650
CRLF2	IL10	ENSMODP00000041017	ENSMODP00000002554	Uncharacterized protein.	Interleukin 10.	0.679
CRLF2	IL15	ENSMODP00000041017	ENSMODP00000042052	Uncharacterized protein.	Interleukin; Belongs to the IL-15/IL-21 family.	0.674
CRLF2	IL17D	ENSMODP00000041017	ENSMODP00000010199	Uncharacterized protein.	Interleukin 17D.	0.666
CRLF2	IL2	ENSMODP00000041017	ENSMODP00000052096	Uncharacterized protein.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.684
CRLF2	IL22	ENSMODP00000041017	ENSMODP00000009164	Uncharacterized protein.	Uncharacterized protein.	0.668
CRLF2	IL7	ENSMODP00000041017	ENSMODP00000049727	Uncharacterized protein.	Uncharacterized protein.	0.830
CRLF2	IL7R	ENSMODP00000041017	ENSMODP00000025476	Uncharacterized protein.	Fibronectin type-III domain-containing protein.	0.997
CRLF2	IL9	ENSMODP00000041017	ENSMODP00000041312	Uncharacterized protein.	Uncharacterized protein.	0.697
CRLF2	JAK1	ENSMODP00000041017	ENSMODP00000001468	Uncharacterized protein.	Protein kinase domain-containing protein.	0.788
CRLF2	JAK3	ENSMODP00000041017	ENSMODP00000032098	Uncharacterized protein.	Tyrosine-protein kinase.	0.400
CRLF2	LOC100021419	ENSMODP00000041017	ENSMODP00000004540	Uncharacterized protein.	Type I interferon 5.	0.650
CRLF2	TYK2	ENSMODP00000041017	ENSMODP00000007046	Uncharacterized protein.	Tyrosine-protein kinase.	0.738
IFN2	CRLF2	ENSMODP00000059244	ENSMODP00000041017	Type I interferon 2.	Uncharacterized protein.	0.650
IFN2	IFNAR2	ENSMODP00000059244	ENSMODP00000045960	Type I interferon 2.	Uncharacterized protein.	0.943
IFN2	IFNGR1	ENSMODP00000059244	ENSMODP00000055686	Type I interferon 2.	Fibronectin type-III domain-containing protein.	0.682
IFN2	IFNGR2	ENSMODP00000059244	ENSMODP00000026342	Type I interferon 2.	Uncharacterized protein.	0.677