STRINGSTRING
LEPR LEPR THPO THPO EPOR EPOR GH1 GH1 PRL PRL CSF3 CSF3 JAK2 JAK2 CSF3R CSF3R GHR GHR PRLR PRLR ENSMODP00000041557 ENSMODP00000041557 LEP LEP EPO EPO
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LEPRUncharacterized protein. (893 aa)
THPOUncharacterized protein. (366 aa)
EPORErythropoietin receptor. (532 aa)
GH1Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues (By similarity); Belongs to the somatotropin/prolactin family. (215 aa)
PRLProlactin; Prolactin acts primarily on the mammary gland by promoting lactation. (228 aa)
CSF3Colony stimulating factor 3. (233 aa)
JAK2Tyrosine-protein kinase. (1130 aa)
CSF3RUncharacterized protein. (866 aa)
GHRGrowth hormone receptor. (630 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (636 aa)
ENSMODP00000041557Uncharacterized protein. (223 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
EPOErythropoietin. (188 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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