(16 nodes) Mixed, incl. GDNF receptor alpha, and Glial cell line-derived neurotrophic factor family network (Monodelphis domestica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RET	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1105 aa)
	ARTN	TGF_BETA_2 domain-containing protein. (278 aa)
	GFRA2	GDNF family receptor alpha-2; Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. (464 aa)
	GFRA3	Uncharacterized protein. (410 aa)
	DOK5	Docking protein 5. (306 aa)
	F7AD67_MONDO	Uncharacterized protein. (437 aa)
	PDGFRL	Platelet derived growth factor receptor like. (384 aa)
	GDNF	Glial cell derived neurotrophic factor. (183 aa)
	NRTN	Neurturin. (222 aa)
	STYK1	Serine/threonine/tyrosine kinase 1. (359 aa)
	TINAGL1	Tubulointerstitial nephritis antigen like 1; Belongs to the peptidase C1 family. (466 aa)
	FAM83B	FAM83 domain-containing protein. (1005 aa)
	DCLK2	Uncharacterized protein. (1631 aa)
	GFRA4	Uncharacterized protein. (355 aa)
	LOC103092471	TGF_BETA_2 domain-containing protein. (355 aa)
	GFRA1	GDNF family receptor alpha 1. (511 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARTN	F7AD67_MONDO	ENSMODP00000003680	ENSMODP00000023426	TGF_BETA_2 domain-containing protein.	Uncharacterized protein.	0.407
ARTN	GDNF	ENSMODP00000003680	ENSMODP00000025432	TGF_BETA_2 domain-containing protein.	Glial cell derived neurotrophic factor.	0.639
ARTN	GFRA1	ENSMODP00000003680	ENSMODP00000059399	TGF_BETA_2 domain-containing protein.	GDNF family receptor alpha 1.	0.407
ARTN	GFRA2	ENSMODP00000003680	ENSMODP00000012228	TGF_BETA_2 domain-containing protein.	GDNF family receptor alpha-2; Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.	0.407
ARTN	GFRA3	ENSMODP00000003680	ENSMODP00000015259	TGF_BETA_2 domain-containing protein.	Uncharacterized protein.	0.407
ARTN	GFRA4	ENSMODP00000003680	ENSMODP00000055169	TGF_BETA_2 domain-containing protein.	Uncharacterized protein.	0.807
ARTN	NRTN	ENSMODP00000003680	ENSMODP00000027120	TGF_BETA_2 domain-containing protein.	Neurturin.	0.689
DOK5	RET	ENSMODP00000020495	ENSMODP00000001452	Docking protein 5.	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.	0.511
F7AD67_MONDO	ARTN	ENSMODP00000023426	ENSMODP00000003680	Uncharacterized protein.	TGF_BETA_2 domain-containing protein.	0.407
F7AD67_MONDO	FAM83B	ENSMODP00000023426	ENSMODP00000043265	Uncharacterized protein.	FAM83 domain-containing protein.	0.634
F7AD67_MONDO	GDNF	ENSMODP00000023426	ENSMODP00000025432	Uncharacterized protein.	Glial cell derived neurotrophic factor.	0.829
F7AD67_MONDO	LOC103092471	ENSMODP00000023426	ENSMODP00000057948	Uncharacterized protein.	TGF_BETA_2 domain-containing protein.	0.748
F7AD67_MONDO	NRTN	ENSMODP00000023426	ENSMODP00000027120	Uncharacterized protein.	Neurturin.	0.683
F7AD67_MONDO	RET	ENSMODP00000023426	ENSMODP00000001452	Uncharacterized protein.	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands.	0.794
F7AD67_MONDO	TINAGL1	ENSMODP00000023426	ENSMODP00000040581	Uncharacterized protein.	Tubulointerstitial nephritis antigen like 1; Belongs to the peptidase C1 family.	0.493
FAM83B	F7AD67_MONDO	ENSMODP00000043265	ENSMODP00000023426	FAM83 domain-containing protein.	Uncharacterized protein.	0.634
FAM83B	TINAGL1	ENSMODP00000043265	ENSMODP00000040581	FAM83 domain-containing protein.	Tubulointerstitial nephritis antigen like 1; Belongs to the peptidase C1 family.	0.447
GDNF	ARTN	ENSMODP00000025432	ENSMODP00000003680	Glial cell derived neurotrophic factor.	TGF_BETA_2 domain-containing protein.	0.639
GDNF	F7AD67_MONDO	ENSMODP00000025432	ENSMODP00000023426	Glial cell derived neurotrophic factor.	Uncharacterized protein.	0.829
GDNF	GFRA1	ENSMODP00000025432	ENSMODP00000059399	Glial cell derived neurotrophic factor.	GDNF family receptor alpha 1.	0.977