(24 nodes) Endothelial cell proliferation network (Monodelphis domestica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (552 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (212 aa)
	BMPER	BMP binding endothelial regulator. (686 aa)
	VSTM4	V-set and transmembrane domain containing 4. (319 aa)
	EPHA2	EPH receptor A2. (886 aa)
	LOXL4	Lysyl oxidase like 4. (752 aa)
	TEK	TEK receptor tyrosine kinase. (1124 aa)
	XBP1	X-box binding protein 1. (204 aa)
	NOX5	NADPH oxidase 5. (745 aa)
	THAP1	THAP domain containing 1. (213 aa)
	ITGB1BP1	Integrin subunit beta 1 binding protein 1. (200 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1035 aa)
	FGF2	Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (156 aa)
	LOXL2	Lysyl oxidase like 2. (713 aa)
	NRARP	NOTCH regulated ankyrin repeat protein. (114 aa)
	LOXL3	Lysyl oxidase like 3. (756 aa)
	SCARB1	Scavenger receptor class B member 1; Belongs to the CD36 family. (519 aa)
	CAV2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
	PRKX	Uncharacterized protein. (419 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1074 aa)
	PROK1	Prokineticin domain-containing protein. (105 aa)
	PROK2	Prokineticin 2. (111 aa)
	NF1	Neurofibromin 1. (2781 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMPER	BMPR2	ENSMODP00000000037	ENSMODP00000020362	BMP binding endothelial regulator.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.501
BMPR2	BMPER	ENSMODP00000020362	ENSMODP00000000037	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	BMP binding endothelial regulator.	0.501
BMPR2	TGFBR1	ENSMODP00000020362	ENSMODP00000015863	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.658
CAV1	CAV2	ENSMODP00000019745	ENSMODP00000044928	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.996
CAV1	EPHA2	ENSMODP00000019745	ENSMODP00000004043	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	EPH receptor A2.	0.446
CAV1	SCARB1	ENSMODP00000019745	ENSMODP00000044237	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.627
CAV1	TGFBR1	ENSMODP00000019745	ENSMODP00000015863	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.596
CAV2	CAV1	ENSMODP00000044928	ENSMODP00000019745	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.996
EPHA2	CAV1	ENSMODP00000004043	ENSMODP00000019745	EPH receptor A2.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.446
EPHA2	SCARB1	ENSMODP00000004043	ENSMODP00000044237	EPH receptor A2.	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.575
FGF2	FGF7	ENSMODP00000023577	ENSMODP00000060027	Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.452
FGF2	TEK	ENSMODP00000023577	ENSMODP00000005260	Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family.	TEK receptor tyrosine kinase.	0.843
FGF7	FGF2	ENSMODP00000060027	ENSMODP00000023577	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family.	0.452
FGF7	PIK3CB	ENSMODP00000060027	ENSMODP00000053456	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.465
FGF7	TEK	ENSMODP00000060027	ENSMODP00000005260	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	TEK receptor tyrosine kinase.	0.775
PIK3CB	FGF7	ENSMODP00000053456	ENSMODP00000060027	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.465
PIK3CB	TEK	ENSMODP00000053456	ENSMODP00000005260	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	TEK receptor tyrosine kinase.	0.549
SCARB1	CAV1	ENSMODP00000044237	ENSMODP00000019745	Scavenger receptor class B member 1; Belongs to the CD36 family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.627
SCARB1	EPHA2	ENSMODP00000044237	ENSMODP00000004043	Scavenger receptor class B member 1; Belongs to the CD36 family.	EPH receptor A2.	0.575
TEK	FGF2	ENSMODP00000005260	ENSMODP00000023577	TEK receptor tyrosine kinase.	Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family.	0.843