35 items (Monodelphis domestica) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BAK1	BCL2 antagonist/killer 1. (204 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (164 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (559 aa)
	CBL	Cbl proto-oncogene. (837 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (1142 aa)
	F7CKG5_MONDO	HSF_DOMAIN domain-containing protein. (525 aa)
	TLK2	Tousled like kinase 2. (750 aa)
	POLB	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
	MAP3K20	Mitogen-activated protein kinase kinase kinase 20. (805 aa)
	CHEK2	Checkpoint kinase 2. (531 aa)
	GTF2H5	General transcription factor IIH subunit 5. (71 aa)
	DCUN1D3	DCN1-like protein. (308 aa)
	PARP1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa)
	FANCD2	FA complementation group D2. (1419 aa)
	BCL2	BCL2 apoptosis regulator. (188 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (435 aa)
	ERCC6	ERCC excision repair 6, chromatin remodeling factor. (1492 aa)
	XRCC6	X-ray repair cross complementing 6. (633 aa)
	BAX	Uncharacterized protein. (296 aa)
	XRCC5	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (701 aa)
	XRCC2	X-ray repair cross complementing 2. (280 aa)
	TIGAR	Uncharacterized protein. (269 aa)
	WRN	WRN RecQ like helicase. (1333 aa)
	PML	Uncharacterized protein. (1118 aa)
	LIG4	DNA ligase. (911 aa)
	BRCA2	Tower domain-containing protein. (3324 aa)
	TMEM109	Transmembrane protein 109. (260 aa)
	ATM	TAN domain-containing protein. (112 aa)
	CRYAB	Crystallin alpha B; Belongs to the small heat shock protein (HSP20) family. (182 aa)
	EGR1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (527 aa)
	ATR	Uncharacterized protein. (159 aa)
	ENSMODP00000051881	ETS domain-containing protein. (526 aa)
	APOBEC1	C->U-editing enzyme APOBEC-1; Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. (235 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (476 aa)
	KDM1A	Lysine demethylase 1A. (909 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	ATR	ENSMODP00000059879	ENSMODP00000052412	TAN domain-containing protein.	Uncharacterized protein.	0.999
ATM	BCL2	ENSMODP00000059879	ENSMODP00000006458	TAN domain-containing protein.	BCL2 apoptosis regulator.	0.434
ATM	BRCA2	ENSMODP00000059879	ENSMODP00000033276	TAN domain-containing protein.	Tower domain-containing protein.	0.930
ATM	CHEK2	ENSMODP00000059879	ENSMODP00000010421	TAN domain-containing protein.	Checkpoint kinase 2.	0.997
ATM	FANCD2	ENSMODP00000059879	ENSMODP00000006723	TAN domain-containing protein.	FA complementation group D2.	0.751
ATM	LIG4	ENSMODP00000059879	ENSMODP00000036738	TAN domain-containing protein.	DNA ligase.	0.749
ATM	MYC	ENSMODP00000059879	ENSMODP00000002125	TAN domain-containing protein.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.549
ATM	PARP1	ENSMODP00000059879	ENSMODP00000007535	TAN domain-containing protein.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.598
ATM	WRN	ENSMODP00000059879	ENSMODP00000037910	TAN domain-containing protein.	WRN RecQ like helicase.	0.988
ATM	XRCC2	ENSMODP00000059879	ENSMODP00000046264	TAN domain-containing protein.	X-ray repair cross complementing 2.	0.732
ATM	XRCC5	ENSMODP00000059879	ENSMODP00000047042	TAN domain-containing protein.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.936
ATM	XRCC6	ENSMODP00000059879	ENSMODP00000050498	TAN domain-containing protein.	X-ray repair cross complementing 6.	0.950
ATR	ATM	ENSMODP00000052412	ENSMODP00000059879	Uncharacterized protein.	TAN domain-containing protein.	0.999
ATR	BRCA2	ENSMODP00000052412	ENSMODP00000033276	Uncharacterized protein.	Tower domain-containing protein.	0.594
ATR	CHEK2	ENSMODP00000052412	ENSMODP00000010421	Uncharacterized protein.	Checkpoint kinase 2.	0.996
ATR	ERCC6	ENSMODP00000052412	ENSMODP00000003046	Uncharacterized protein.	ERCC excision repair 6, chromatin remodeling factor.	0.532
ATR	FANCD2	ENSMODP00000052412	ENSMODP00000006723	Uncharacterized protein.	FA complementation group D2.	0.857
ATR	LIG4	ENSMODP00000052412	ENSMODP00000036738	Uncharacterized protein.	DNA ligase.	0.681
ATR	WRN	ENSMODP00000052412	ENSMODP00000037910	Uncharacterized protein.	WRN RecQ like helicase.	0.997
ATR	XRCC5	ENSMODP00000052412	ENSMODP00000047042	Uncharacterized protein.	X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family.	0.733