(58 nodes) Negative regulation of autophagy network (Monodelphis domestica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	F6QBX0_MONDO	Uncharacterized protein. (98 aa)
	FEZ2	Fasciculation and elongation protein zeta 2. (374 aa)
	NUPR1	Uncharacterized protein. (82 aa)
	TSC2	TSC complex subunit 2. (1830 aa)
	ADRA1A	Adrenoceptor alpha 1A. (465 aa)
	UBQLN4	Ubiquilin 4. (671 aa)
	F7FF42_MONDO	Myotubularin phosphatase domain-containing protein. (570 aa)
	TMEM39A	Transmembrane protein 39A. (488 aa)
	WASHC1	WASH complex subunit 1. (467 aa)
	CTSA	Carboxypeptidase; Belongs to the peptidase S10 family. (471 aa)
	IL10RA	Fibronectin type-III domain-containing protein. (605 aa)
	WDR6	WD_REPEATS_REGION domain-containing protein. (920 aa)
	TSC1	TSC complex subunit 1. (1152 aa)
	F7BA89_MONDO	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (740 aa)
	HTR2B	5-hydroxytryptamine receptor 2B; Belongs to the G-protein coupled receptor 1 family. (473 aa)
	MTMR9	Myotubularin related protein 9. (549 aa)
	F6WBW3_MONDO	Uncharacterized protein. (653 aa)
	TSPO	Uncharacterized protein. (275 aa)
	LRRK2	Leucine rich repeat kinase 2. (2527 aa)
	SEC22B	SEC22 homolog B, vesicle trafficking protein (gene/pseudogene); Belongs to the synaptobrevin family. (216 aa)
	POLDIP2	DNA polymerase delta interacting protein 2. (367 aa)
	USP30	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (443 aa)
	PHF23	PHD finger protein 23. (432 aa)
	CPTP	Ceramide-1-phosphate transfer protein. (239 aa)
	BCL2	BCL2 apoptosis regulator. (188 aa)
	FEZ1	Fasciculation and elongation protein zeta 1. (408 aa)
	FOXK2	Fork-head domain-containing protein. (467 aa)
	IL10	Interleukin 10. (173 aa)
	LEPR	Uncharacterized protein. (893 aa)
	HMOX1	Uncharacterized protein. (290 aa)
	FOXK1	Forkhead box K1. (594 aa)
	NPC1	NPC intracellular cholesterol transporter 1. (1281 aa)
	TMEM39B	Uncharacterized protein. (331 aa)
	NRBP2	Nuclear receptor binding protein 2. (464 aa)
	F7F5B8_MONDO	Uncharacterized protein. (1088 aa)
	SMCR8	SMCR8-C9orf72 complex subunit. (791 aa)
	F6U2S4_MONDO	Deacetylase sirtuin-type domain-containing protein. (261 aa)
	ENSMODP00000041557	Uncharacterized protein. (223 aa)
	DAP	Uncharacterized protein. (185 aa)
	SCFD1	Sec1 family domain containing 1; Belongs to the STXBP/unc-18/SEC1 family. (612 aa)
	CLEC16A	C-type lectin domain containing 16A. (1049 aa)
	EHMT2	Euchromatic histone lysine methyltransferase 2. (961 aa)
	DAPL1	Death associated protein like 1. (106 aa)
	TIGAR	Uncharacterized protein. (269 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	SLC7A5	Solute carrier family 7 member 5. (533 aa)
	BMF	Uncharacterized protein. (184 aa)
	MTM1	Myotubularin 1. (605 aa)
	LZTS1	Leucine zipper tumor suppressor 1. (608 aa)
	RUBCN	Rubicon autophagy regulator. (1018 aa)
	STAT3	Signal transducer and activator of transcription. (805 aa)
	SMG1	SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3671 aa)
	PINK1	Protein kinase domain-containing protein. (573 aa)
	RNF41	RING-type domain-containing protein. (201 aa)
	MTOR	Serine/threonine-protein kinase mTOR. (1040 aa)
	LOC100030714	Uncharacterized protein. (272 aa)
	F6T9Y7_MONDO	Carboxypeptidase; Belongs to the peptidase S10 family. (490 aa)
	KLHL22	BTB domain-containing protein. (697 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL2	BMF	ENSMODP00000006458	ENSMODP00000047994	BCL2 apoptosis regulator.	Uncharacterized protein.	0.878
BCL2	HMOX1	ENSMODP00000006458	ENSMODP00000001389	BCL2 apoptosis regulator.	Uncharacterized protein.	0.403
BCL2	IL10	ENSMODP00000006458	ENSMODP00000002554	BCL2 apoptosis regulator.	Interleukin 10.	0.448
BCL2	LEP	ENSMODP00000006458	ENSMODP00000044791	BCL2 apoptosis regulator.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.552
BCL2	LOC100030714	ENSMODP00000006458	ENSMODP00000059819	BCL2 apoptosis regulator.	Uncharacterized protein.	0.403
BCL2	PINK1	ENSMODP00000006458	ENSMODP00000053610	BCL2 apoptosis regulator.	Protein kinase domain-containing protein.	0.414
BCL2	STAT3	ENSMODP00000006458	ENSMODP00000052576	BCL2 apoptosis regulator.	Signal transducer and activator of transcription.	0.721
BMF	BCL2	ENSMODP00000047994	ENSMODP00000006458	Uncharacterized protein.	BCL2 apoptosis regulator.	0.878
CLEC16A	RNF41	ENSMODP00000042541	ENSMODP00000056165	C-type lectin domain containing 16A.	RING-type domain-containing protein.	0.621
CTSA	F6T9Y7_MONDO	ENSMODP00000017131	ENSMODP00000017770	Carboxypeptidase; Belongs to the peptidase S10 family.	Carboxypeptidase; Belongs to the peptidase S10 family.	0.903
ENSMODP00000041557	LEP	ENSMODP00000041557	ENSMODP00000044791	Uncharacterized protein.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.704
ENSMODP00000041557	LEPR	ENSMODP00000041557	ENSMODP00000001394	Uncharacterized protein.	Uncharacterized protein.	0.731
ENSMODP00000041557	STAT3	ENSMODP00000041557	ENSMODP00000052576	Uncharacterized protein.	Signal transducer and activator of transcription.	0.452
F6T9Y7_MONDO	CTSA	ENSMODP00000017770	ENSMODP00000017131	Carboxypeptidase; Belongs to the peptidase S10 family.	Carboxypeptidase; Belongs to the peptidase S10 family.	0.903
F6U2S4_MONDO	PINK1	ENSMODP00000038370	ENSMODP00000053610	Deacetylase sirtuin-type domain-containing protein.	Protein kinase domain-containing protein.	0.578
F7BA89_MONDO	MTOR	ENSMODP00000013940	ENSMODP00000057648	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Serine/threonine-protein kinase mTOR.	0.925
F7BA89_MONDO	SMG1	ENSMODP00000013940	ENSMODP00000053431	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family.	0.546
F7BA89_MONDO	STAT3	ENSMODP00000013940	ENSMODP00000052576	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Signal transducer and activator of transcription.	0.518
F7BA89_MONDO	TSC1	ENSMODP00000013940	ENSMODP00000015755	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	TSC complex subunit 1.	0.817
F7BA89_MONDO	TSC2	ENSMODP00000013940	ENSMODP00000019988	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	TSC complex subunit 2.	0.835