(48 nodes) Regulation of glucose transmembrane transport network (Monodelphis domestica)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	APPL1	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (662 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	RHOQ	Ras homolog family member Q. (205 aa)
	H9H5X6_MONDO	Uncharacterized protein. (86 aa)
	APPL2	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (663 aa)
	IGF1	Insulin like growth factor 1. (225 aa)
	CAPN10	Calpain 10; Belongs to the peptidase C2 family. (676 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (599 aa)
	ASPSCR1	Uncharacterized protein. (409 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (212 aa)
	FFAR4	G_PROTEIN_RECEP_F1_2 domain-containing protein. (370 aa)
	FABP5	Fatty acid binding protein 5; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)
	RNASEL	Uncharacterized protein. (764 aa)
	OPN3	Opsin 3; Belongs to the G-protein coupled receptor 1 family. (526 aa)
	PTH	Uncharacterized protein. (137 aa)
	GRB10	Growth factor receptor bound protein 10. (596 aa)
	NFE2L2	Nuclear factor, erythroid 2 like 2. (585 aa)
	PEA15	Proliferation and apoptosis adaptor protein 15. (130 aa)
	EDN1	Endothelin 1. (214 aa)
	HK2	Hexokinase 2. (932 aa)
	NR4A3	Nuclear receptor subfamily 4 group A member 3. (623 aa)
	ADIPOQ	Adiponectin, C1Q and collagen domain containing. (256 aa)
	STXBP4	Syntaxin binding protein 4. (580 aa)
	INSR	Tyrosine-protein kinase receptor. (1378 aa)
	GPC3	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (486 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (229 aa)
	F7ASC3_MONDO	Uncharacterized protein. (274 aa)
	OCLN	Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (523 aa)
	SLC1A2	Amino acid transporter. (574 aa)
	OSBPL8	Oxysterol-binding protein; Belongs to the OSBP family. (890 aa)
	RTN2	Reticulon. (439 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (563 aa)
	PID1	Phosphotyrosine interaction domain containing 1. (203 aa)
	F6QHP1_MONDO	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1274 aa)
	F6XDE0_MONDO	Fibrinogen C-terminal domain-containing protein. (285 aa)
	LOC100029567	Fibrinogen C-terminal domain-containing protein. (311 aa)
	TRIB3	Protein kinase domain-containing protein. (146 aa)
	CREBL2	BZIP domain-containing protein. (130 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
	INPP5K	Inositol polyphosphate-5-phosphatase K. (465 aa)
	CLIP3	CAP-Gly domain containing linker protein 3. (595 aa)
	SORBS1	Sorbin and SH3 domain containing 1. (1277 aa)
	MEF2A	Myocyte enhancer factor 2A. (505 aa)
	STXBP3	Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (594 aa)
	LOC100029540	Fibrinogen C-terminal domain-containing protein. (315 aa)
	OSTN	Osteocrin. (142 aa)
	C2CD5	C2 calcium dependent domain containing 5. (1038 aa)
	ENSMODP00000059044	SH2 domain-containing protein. (79 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADIPOQ	APPL1	ENSMODP00000016761	ENSMODP00000000103	Adiponectin, C1Q and collagen domain containing.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	0.746
ADIPOQ	APPL2	ENSMODP00000016761	ENSMODP00000002413	Adiponectin, C1Q and collagen domain containing.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.746
ADIPOQ	LEP	ENSMODP00000016761	ENSMODP00000044791	Adiponectin, C1Q and collagen domain containing.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.893
ADIPOQ	TNF	ENSMODP00000016761	ENSMODP00000019686	Adiponectin, C1Q and collagen domain containing.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.545
APPL1	ADIPOQ	ENSMODP00000000103	ENSMODP00000016761	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Adiponectin, C1Q and collagen domain containing.	0.746
APPL1	APPL2	ENSMODP00000000103	ENSMODP00000002413	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	0.991
APPL1	INSR	ENSMODP00000000103	ENSMODP00000018879	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Tyrosine-protein kinase receptor.	0.517
APPL1	PEA15	ENSMODP00000000103	ENSMODP00000012034	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	Proliferation and apoptosis adaptor protein 15.	0.667
APPL2	ADIPOQ	ENSMODP00000002413	ENSMODP00000016761	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Adiponectin, C1Q and collagen domain containing.	0.746
APPL2	APPL1	ENSMODP00000002413	ENSMODP00000000103	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1.	0.991
APPL2	INSR	ENSMODP00000002413	ENSMODP00000018879	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Tyrosine-protein kinase receptor.	0.517
APPL2	PEA15	ENSMODP00000002413	ENSMODP00000012034	Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2.	Proliferation and apoptosis adaptor protein 15.	0.667
BRAF	F6QHP1_MONDO	ENSMODP00000034042	ENSMODP00000036990	B-Raf proto-oncogene, serine/threonine kinase.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...]	0.444
EDN1	EDNRA	ENSMODP00000013239	ENSMODP00000000789	Endothelin 1.	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	0.999
EDN1	LEP	ENSMODP00000013239	ENSMODP00000044791	Endothelin 1.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.461
EDN1	TNF	ENSMODP00000013239	ENSMODP00000019686	Endothelin 1.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.475
EDNRA	EDN1	ENSMODP00000000789	ENSMODP00000013239	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.	Endothelin 1.	0.999
ENSMODP00000059044	INSR	ENSMODP00000059044	ENSMODP00000018879	SH2 domain-containing protein.	Tyrosine-protein kinase receptor.	0.475
F6QHP1_MONDO	BRAF	ENSMODP00000036990	ENSMODP00000034042	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...]	B-Raf proto-oncogene, serine/threonine kinase.	0.444
F7ASC3_MONDO	INSR	ENSMODP00000020528	ENSMODP00000018879	Uncharacterized protein.	Tyrosine-protein kinase receptor.	0.475