(23 nodes) Regulation of macrophage cytokine production network (Monodelphis domestica)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	SEMA7A	Semaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (675 aa)
	PYCARD	PYD and CARD domain containing. (195 aa)
	AXL	AXL receptor tyrosine kinase. (886 aa)
	F6Q6J4_MONDO	UBIQUITIN_CONJUGAT_2 domain-containing protein. (315 aa)
	CARD9	Uncharacterized protein. (377 aa)
	SIRT1	Deacetylase sirtuin-type domain-containing protein. (713 aa)
	PLCG2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1264 aa)
	NLRX1	NLR family member X1. (975 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (1012 aa)
	F6YH86_MONDO	UBIQUITIN_CONJUGAT_2 domain-containing protein. (294 aa)
	CUEDC2	Uncharacterized protein. (192 aa)
	IRAK3	Interleukin 1 receptor associated kinase 3. (591 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (424 aa)
	RIPK2	Receptor interacting serine/threonine kinase 2. (540 aa)
	TLR3	Toll like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
	SPON2	Spondin 2. (330 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (408 aa)
	MAPKAPK2	MAPK activated protein kinase 2. (388 aa)
	RTN4	Reticulon. (1217 aa)
	PANX1	Pannexin; Structural component of the gap junctions and the hemichannels. (431 aa)
	CD74	CD74 molecule. (281 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (938 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXL	PLCG2	ENSMODP00000031323	ENSMODP00000018986	AXL receptor tyrosine kinase.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.918
CARD9	NOD1	ENSMODP00000021908	ENSMODP00000060008	Uncharacterized protein.	Nucleotide binding oligomerization domain containing 1.	0.500
CARD9	NOD2	ENSMODP00000021908	ENSMODP00000016381	Uncharacterized protein.	Nucleotide binding oligomerization domain containing 2.	0.767
CARD9	RIPK2	ENSMODP00000021908	ENSMODP00000009583	Uncharacterized protein.	Receptor interacting serine/threonine kinase 2.	0.944
IRAK3	SEMA7A	ENSMODP00000011339	ENSMODP00000037486	Interleukin 1 receptor associated kinase 3.	Semaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family.	0.486
IRAK3	TGFB3	ENSMODP00000011339	ENSMODP00000007007	Interleukin 1 receptor associated kinase 3.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.419
NLRX1	TLR3	ENSMODP00000016571	ENSMODP00000005984	NLR family member X1.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.422
NOD1	CARD9	ENSMODP00000060008	ENSMODP00000021908	Nucleotide binding oligomerization domain containing 1.	Uncharacterized protein.	0.500
NOD1	NOD2	ENSMODP00000060008	ENSMODP00000016381	Nucleotide binding oligomerization domain containing 1.	Nucleotide binding oligomerization domain containing 2.	0.808
NOD1	PYCARD	ENSMODP00000060008	ENSMODP00000037460	Nucleotide binding oligomerization domain containing 1.	PYD and CARD domain containing.	0.539
NOD1	RIPK2	ENSMODP00000060008	ENSMODP00000009583	Nucleotide binding oligomerization domain containing 1.	Receptor interacting serine/threonine kinase 2.	0.993
NOD2	CARD9	ENSMODP00000016381	ENSMODP00000021908	Nucleotide binding oligomerization domain containing 2.	Uncharacterized protein.	0.767
NOD2	NOD1	ENSMODP00000016381	ENSMODP00000060008	Nucleotide binding oligomerization domain containing 2.	Nucleotide binding oligomerization domain containing 1.	0.808
NOD2	PYCARD	ENSMODP00000016381	ENSMODP00000037460	Nucleotide binding oligomerization domain containing 2.	PYD and CARD domain containing.	0.464
NOD2	RIPK2	ENSMODP00000016381	ENSMODP00000009583	Nucleotide binding oligomerization domain containing 2.	Receptor interacting serine/threonine kinase 2.	0.996
NOD2	TLR3	ENSMODP00000016381	ENSMODP00000005984	Nucleotide binding oligomerization domain containing 2.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.429
PANX1	TLR3	ENSMODP00000000334	ENSMODP00000005984	Pannexin; Structural component of the gap junctions and the hemichannels.	Toll like receptor 3; Belongs to the Toll-like receptor family.	0.408
PLCG2	AXL	ENSMODP00000018986	ENSMODP00000031323	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	AXL receptor tyrosine kinase.	0.918
PYCARD	NOD1	ENSMODP00000037460	ENSMODP00000060008	PYD and CARD domain containing.	Nucleotide binding oligomerization domain containing 1.	0.539
PYCARD	NOD2	ENSMODP00000037460	ENSMODP00000016381	PYD and CARD domain containing.	Nucleotide binding oligomerization domain containing 2.	0.464