STRINGSTRING
NKX3-1 NKX3-1 SEMA3E SEMA3E HGF HGF F6WYG5_MONDO F6WYG5_MONDO SIRT1 SIRT1 PTPN6 PTPN6 NOP53 NOP53 MYOC MYOC STAMBP STAMBP ENSMODP00000059161 ENSMODP00000059161 LOC103099055 LOC103099055 IGF1R IGF1R LOC103101367 LOC103101367 ENSMODP00000055709 ENSMODP00000055709 RELN RELN SERPINE2 SERPINE2 DAB2IP DAB2IP PTK2 PTK2 CAT CAT ENSMODP00000052695 ENSMODP00000052695 ROR1 ROR1 LOC103102395 LOC103102395 RASGRP1 RASGRP1 SEMA4D SEMA4D PTPN13 PTPN13 PRR5 PRR5 FSHR FSHR PDGFC PDGFC IGF1 IGF1 TEK TEK TGFB2 TGFB2 PIK3AP1 PIK3AP1 CEP55 CEP55 FN1 FN1 PIK3IP1 PIK3IP1 LEP LEP LIME1 LIME1 OSM OSM UBE3A UBE3A SLC9A3R1 SLC9A3R1 NCF1 NCF1 NEDD4 NEDD4 UNC5B UNC5B EGFR EGFR FLT1 FLT1 AGT AGT PDGFB PDGFB DCN DCN CSF3 CSF3 CBL CBL F2R F2R PPARD PPARD RGL2 RGL2 HCLS1 HCLS1 NTRK2 NTRK2 PRR5L PRR5L LOC100024614 LOC100024614 DIPK2A DIPK2A LOC100017469 LOC100017469 KDR KDR F2 F2 CRYBA1 CRYBA1 ROR2 ROR2 CRNN CRNN FGF2 FGF2 INSR INSR JAK2 JAK2 WNT16 WNT16 TSC2 TSC2 NLRC3 NLRC3 NTRK1 NTRK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NKX3-1NK3 homeobox 1. (258 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (715 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
F6WYG5_MONDOHCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (231 aa)
SIRT1Deacetylase sirtuin-type domain-containing protein. (713 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
NOP53NOP53 ribosome biogenesis factor. (497 aa)
MYOCMyocilin. (478 aa)
STAMBPMPN domain-containing protein. (246 aa)
ENSMODP00000059161FERM domain-containing protein. (121 aa)
LOC103099055Uncharacterized protein; Belongs to the semaphorin family. (776 aa)
IGF1RTyrosine-protein kinase receptor. (1259 aa)
LOC103101367Uncharacterized protein. (211 aa)
ENSMODP00000055709Uncharacterized protein. (84 aa)
RELNReelin. (3458 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (469 aa)
DAB2IPDAB2 interacting protein. (1180 aa)
PTK2Uncharacterized protein. (161 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family. (529 aa)
ENSMODP00000052695Uncharacterized protein. (143 aa)
ROR1Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (920 aa)
LOC103102395Uncharacterized protein. (207 aa)
RASGRP1RAS guanyl releasing protein 1. (861 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (737 aa)
PTPN13Tyrosine-protein phosphatase non-receptor type 13; Regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling. (2335 aa)
PRR5Uncharacterized protein. (408 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (700 aa)
PDGFCPlatelet derived growth factor C. (345 aa)
IGF1Insulin like growth factor 1. (225 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (408 aa)
PIK3AP1Phosphoinositide-3-kinase adaptor protein 1. (806 aa)
CEP55Centrosomal protein 55. (408 aa)
FN1Fibronectin 1. (2482 aa)
PIK3IP1Phosphoinositide-3-kinase interacting protein 1. (243 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
LIME1Uncharacterized protein. (249 aa)
OSMUncharacterized protein. (206 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (878 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (366 aa)
NCF1Neutrophil cytosolic factor 1. (389 aa)
NEDD4NEDD4 E3 ubiquitin protein ligase. (1238 aa)
UNC5BUnc-5 netrin receptor B. (865 aa)
EGFRReceptor protein-tyrosine kinase. (1213 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1341 aa)
AGTAngiotensinogen; Belongs to the serpin family. (469 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (235 aa)
DCNDecorin; May affect the rate of fibrils formation. (356 aa)
CSF3Colony stimulating factor 3. (233 aa)
CBLCbl proto-oncogene. (837 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (426 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
RGL2Ral guanine nucleotide dissociation stimulator like 2. (869 aa)
HCLS1SH3 domain-containing protein. (408 aa)
NTRK2Tyrosine-protein kinase receptor. (750 aa)
PRR5LProline rich 5 like. (369 aa)
LOC100024614SERPIN domain-containing protein; Belongs to the serpin family. (422 aa)
DIPK2ADivergent protein kinase domain 2A. (430 aa)
LOC100017469Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1570 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1349 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
CRYBA1Crystallin beta A1; Belongs to the beta/gamma-crystallin family. (215 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (943 aa)
CRNNEF-hand domain-containing protein. (627 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (156 aa)
INSRTyrosine-protein kinase receptor. (1378 aa)
JAK2Tyrosine-protein kinase. (1130 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (375 aa)
TSC2TSC complex subunit 2. (1830 aa)
NLRC3NLR family CARD domain containing 3. (1109 aa)
NTRK1Tyrosine-protein kinase receptor. (739 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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