(47 nodes) Myotube differentiation network (Monodelphis domestica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BARX2	BARX homeobox 2. (279 aa)
	IGF1	Insulin like growth factor 1. (225 aa)
	TMEM182	Transmembrane protein 182. (229 aa)
	SORT1	Sortilin. (693 aa)
	KEL	Kell metallo-endopeptidase (Kell blood group). (714 aa)
	KLF5	Kruppel like factor 5. (464 aa)
	F6S9P8_MONDO	Tetraspanin. (224 aa)
	ADAMTS5	ADAM metallopeptidase with thrombospondin type 1 motif 5. (944 aa)
	SKI	SKI proto-oncogene. (677 aa)
	HOMER1	Homer scaffold protein 1. (410 aa)
	PLEKHO1	Uncharacterized protein. (225 aa)
	BCL9	BCL9 transcription coactivator. (1426 aa)
	CD9	Tetraspanin. (227 aa)
	SPG11	SPG11 vesicle trafficking associated, spatacsin. (2446 aa)
	P2RX2	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (473 aa)
	F6U275_MONDO	Uncharacterized protein. (484 aa)
	DOCK5	Dedicator of cytokinesis 5; Belongs to the DOCK family. (1839 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (335 aa)
	DYRK1B	Dual specificity tyrosine phosphorylation regulated kinase 1B. (728 aa)
	P2RX2-2	Uncharacterized protein. (64 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (802 aa)
	LOC100017154	Uncharacterized protein. (390 aa)
	KLHL41	Kelch like family member 41. (948 aa)
	MEF2C	Myocyte enhancer factor 2C. (483 aa)
	CAV2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
	ENSMODP00000048962	Uncharacterized protein. (66 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (242 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (785 aa)
	F6VQE9_MONDO	Uncharacterized protein. (435 aa)
	NPHS1	NPHS1 adhesion molecule, nephrin. (1236 aa)
	KLHL40	Kelch like family member 40. (486 aa)
	RYR1	Ryanodine receptor 1. (4131 aa)
	MYMK	Myomaker, myoblast fusion factor. (221 aa)
	DNER	Delta/notch like EGF repeat containing. (732 aa)
	NFATC2	Nuclear factor of activated T cells 2. (927 aa)
	ENSMODP00000051179	Uncharacterized protein. (68 aa)
	F6PFW3_MONDO	Tetraspanin. (225 aa)
	RIPOR2	PL48 domain-containing protein. (1046 aa)
	BIN3	Bridging integrator 3. (253 aa)
	SIX4	SIX homeobox 4. (788 aa)
	DOCK2	Dedicator of cytokinesis 2; Belongs to the DOCK family. (1825 aa)
	F6PU44_MONDO	DHR-2 domain-containing protein; Belongs to the DOCK family. (930 aa)
	MYOD1	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (321 aa)
	SMYD3	SET domain-containing protein. (257 aa)
	ADAMTS15	ADAM metallopeptidase with thrombospondin type 1 motif 15. (950 aa)
	PTGFRN	Prostaglandin F2 receptor inhibitor. (883 aa)
	TANC1	Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1. (1794 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAV2	CAV3	ENSMODP00000044928	ENSMODP00000049955	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.995
CAV2	ITGB1	ENSMODP00000044928	ENSMODP00000040537	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Integrin beta; Belongs to the integrin beta chain family.	0.919
CAV3	CAV2	ENSMODP00000049955	ENSMODP00000044928	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.995
CAV3	ITGB1	ENSMODP00000049955	ENSMODP00000040537	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Integrin beta; Belongs to the integrin beta chain family.	0.918
CAV3	RYR1	ENSMODP00000049955	ENSMODP00000016617	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Ryanodine receptor 1.	0.498
CD9	ITGB1	ENSMODP00000022507	ENSMODP00000040537	Tetraspanin.	Integrin beta; Belongs to the integrin beta chain family.	0.676
CD9	PTGFRN	ENSMODP00000022507	ENSMODP00000006270	Tetraspanin.	Prostaglandin F2 receptor inhibitor.	0.703
F6PFW3_MONDO	ITGB1	ENSMODP00000034738	ENSMODP00000040537	Tetraspanin.	Integrin beta; Belongs to the integrin beta chain family.	0.676
F6PFW3_MONDO	PTGFRN	ENSMODP00000034738	ENSMODP00000006270	Tetraspanin.	Prostaglandin F2 receptor inhibitor.	0.703
F6S9P8_MONDO	ITGB1	ENSMODP00000000969	ENSMODP00000040537	Tetraspanin.	Integrin beta; Belongs to the integrin beta chain family.	0.676
F6S9P8_MONDO	PTGFRN	ENSMODP00000000969	ENSMODP00000006270	Tetraspanin.	Prostaglandin F2 receptor inhibitor.	0.703
F6VQE9_MONDO	RYR1	ENSMODP00000017520	ENSMODP00000016617	Uncharacterized protein.	Ryanodine receptor 1.	0.507
ITGB1	CAV2	ENSMODP00000040537	ENSMODP00000044928	Integrin beta; Belongs to the integrin beta chain family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.919
ITGB1	CAV3	ENSMODP00000040537	ENSMODP00000049955	Integrin beta; Belongs to the integrin beta chain family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.918
ITGB1	CD9	ENSMODP00000040537	ENSMODP00000022507	Integrin beta; Belongs to the integrin beta chain family.	Tetraspanin.	0.676
ITGB1	F6PFW3_MONDO	ENSMODP00000040537	ENSMODP00000034738	Integrin beta; Belongs to the integrin beta chain family.	Tetraspanin.	0.676
ITGB1	F6S9P8_MONDO	ENSMODP00000040537	ENSMODP00000000969	Integrin beta; Belongs to the integrin beta chain family.	Tetraspanin.	0.676
KLHL40	SMO	ENSMODP00000016994	ENSMODP00000018347	Kelch like family member 40.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.505
KLHL40	TMEM182	ENSMODP00000016994	ENSMODP00000002972	Kelch like family member 40.	Transmembrane protein 182.	0.403
KLHL41	SMO	ENSMODP00000041794	ENSMODP00000018347	Kelch like family member 41.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.526