(58 nodes) Sarcoplasmic reticulum network (Monodelphis domestica)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	CALR	Calreticulin. (418 aa)
	SRI	Sorcin. (234 aa)
	PBDC1	Polysacc_synt_4 domain-containing protein. (133 aa)
	CASQ1	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (395 aa)
	SGCD	Sarcoglycan delta. (237 aa)
	MRVI1	Murine retrovirus integration site 1 homolog. (758 aa)
	JPH1	Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (659 aa)
	NOL3	CARD domain-containing protein. (279 aa)
	CASQ2	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (416 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (2733 aa)
	JPH3	Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (755 aa)
	FKBP1B	Peptidylprolyl isomerase. (108 aa)
	NOS1AP	PID domain-containing protein. (705 aa)
	F7F7P9_MONDO	Uncharacterized protein. (359 aa)
	MTMR12	Myotubularin related protein 12. (789 aa)
	TMEM109	Transmembrane protein 109. (260 aa)
	THBS4	Thrombospondin 4. (955 aa)
	F6TTE4_MONDO	PID domain-containing protein. (203 aa)
	FKBP1A	Peptidylprolyl isomerase. (108 aa)
	FSD2	Fibronectin type III and SPRY domain containing 2. (739 aa)
	AKAP6	A-kinase anchoring protein 6. (2333 aa)
	S100A1	Protein S100; Belongs to the S-100 family. (94 aa)
	F6WYG5_MONDO	HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (231 aa)
	CACNA2D1	Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (960 aa)
	CCDC78	DUF4472 domain-containing protein. (592 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2. (2698 aa)
	ATP2A1	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (948 aa)
	TMEM38A	Transmembrane protein 38A. (303 aa)
	RYR1	Ryanodine receptor 1. (4131 aa)
	REEP5	Receptor expression-enhancing protein. (189 aa)
	PLN	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
	NOS1	Nitric oxide synthase 1. (1464 aa)
	RTN2	Reticulon. (439 aa)
	F6XCF5_MONDO	Peptidylprolyl isomerase. (103 aa)
	MANF	Uncharacterized protein. (181 aa)
	HSP90B1	Heat shock protein 90 beta family member 1. (835 aa)
	KLHL41	Kelch like family member 41. (948 aa)
	ENSMODP00000043447	EF-hand domain-containing protein; Belongs to the S-100 family. (72 aa)
	THBS1	Thrombospondin 1. (1197 aa)
	DHRS7C	Dehydrogenase/reductase 7C; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (383 aa)
	ENSMODP00000045422	Cation_ATPase_C domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (763 aa)
	RYR2	Ryanodine receptor 2. (4900 aa)
	STIM1	Stromal interaction molecule 1. (776 aa)
	CHERP	Calcium homeostasis endoplasmic reticulum protein. (946 aa)
	ENSMODP00000047579	Uncharacterized protein. (103 aa)
	RASD1	Uncharacterized protein. (278 aa)
	P3H2	Prolyl 3-hydroxylase 2. (684 aa)
	SYNE2	Spectrin repeat containing nuclear envelope protein 2. (6528 aa)
	JPH2	Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (742 aa)
	LOC100029733	Peptidylprolyl isomerase. (101 aa)
	RYR3	Ryanodine receptor 3. (4841 aa)
	ENSMODP00000052695	Uncharacterized protein. (143 aa)
	SRL	Sarcalumenin; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (472 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (2608 aa)
	ATP2A2	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
	TRDN	Uncharacterized protein. (275 aa)
	CACNA2D1-2	Uncharacterized protein. (105 aa)
	POMT1	Protein O-mannosyltransferase 1. (725 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKAP6	RYR1	ENSMODP00000021971	ENSMODP00000016617	A-kinase anchoring protein 6.	Ryanodine receptor 1.	0.403
AKAP6	RYR2	ENSMODP00000021971	ENSMODP00000046276	A-kinase anchoring protein 6.	Ryanodine receptor 2.	0.754
ATP2A1	ATP2A2	ENSMODP00000019420	ENSMODP00000054285	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.908
ATP2A1	CASQ1	ENSMODP00000019420	ENSMODP00000012053	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.402
ATP2A1	CASQ2	ENSMODP00000019420	ENSMODP00000006048	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle.	0.402
ATP2A1	ENSMODP00000045422	ENSMODP00000019420	ENSMODP00000045422	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Cation_ATPase_C domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	0.904
ATP2A1	PLN	ENSMODP00000019420	ENSMODP00000029517	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.	0.988
ATP2A1	RYR1	ENSMODP00000019420	ENSMODP00000016617	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Ryanodine receptor 1.	0.742
ATP2A1	SRL	ENSMODP00000019420	ENSMODP00000053021	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Sarcalumenin; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.607
ATP2A1	TRDN	ENSMODP00000019420	ENSMODP00000054571	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Uncharacterized protein.	0.468
ATP2A2	ATP2A1	ENSMODP00000054285	ENSMODP00000019420	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	0.908
ATP2A2	ENSMODP00000043447	ENSMODP00000054285	ENSMODP00000043447	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	EF-hand domain-containing protein; Belongs to the S-100 family.	0.495
ATP2A2	ENSMODP00000045422	ENSMODP00000054285	ENSMODP00000045422	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Cation_ATPase_C domain-containing protein; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.	0.904
ATP2A2	ITPR1	ENSMODP00000054285	ENSMODP00000005545	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Inositol 1,4,5-trisphosphate receptor type 1.	0.518
ATP2A2	PLN	ENSMODP00000054285	ENSMODP00000029517	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.	0.990
ATP2A2	RYR1	ENSMODP00000054285	ENSMODP00000016617	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Ryanodine receptor 1.	0.481
ATP2A2	RYR2	ENSMODP00000054285	ENSMODP00000046276	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Ryanodine receptor 2.	0.618
ATP2A2	S100A1	ENSMODP00000054285	ENSMODP00000021678	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Protein S100; Belongs to the S-100 family.	0.495
ATP2A2	SRL	ENSMODP00000054285	ENSMODP00000053021	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Sarcalumenin; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.559
ATP2A2	STIM1	ENSMODP00000054285	ENSMODP00000046909	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.	Stromal interaction molecule 1.	0.450