STRINGSTRING
FLT4 FLT4 ENSMODP00000045874 ENSMODP00000045874 EFEMP1 EFEMP1 LEP LEP ABL1 ABL1 INSRR INSRR FER FER DSTYK DSTYK FGFR4 FGFR4 DYRK1A DYRK1A ENSMODP00000042930 ENSMODP00000042930 IL15 IL15 ENSMODP00000041354 ENSMODP00000041354 LOC103105989 LOC103105989 STYK1 STYK1 MELK MELK TTK TTK KIT KIT NTRK2 NTRK2 NTRK3 NTRK3 CLK2 CLK2 JAK3 JAK3 AXL AXL EIF2AK2 EIF2AK2 YES1 YES1 EPHA4 EPHA4 LOC100017469 LOC100017469 EPHA5 EPHA5 ERBB3 ERBB3 FLT3 FLT3 FYN FYN TNK2 TNK2 ERBB2 ERBB2 FGFR3 FGFR3 IL2 IL2 WEE1 WEE1 ENSMODP00000052651 ENSMODP00000052651 PTK2 PTK2 MUSK MUSK SYK SYK RELN RELN SIRT6 SIRT6 ENSMODP00000055672 ENSMODP00000055672 ENSMODP00000056005 ENSMODP00000056005 ENSMODP00000056551 ENSMODP00000056551 LYN LYN CNTF CNTF DYRK1B DYRK1B MERTK MERTK ENSMODP00000058991 ENSMODP00000058991 IGF1R IGF1R ENSMODP00000059161 ENSMODP00000059161 BMX BMX EPHB3 EPHB3 KDR KDR PDGFRA PDGFRA TEC TEC TXK TXK HCK HCK FES FES ROR2 ROR2 PDGFRL PDGFRL TTBK1 TTBK1 F7C7H2_MONDO F7C7H2_MONDO HPX HPX EPHB1 EPHB1 PTPN6 PTPN6 EPHA7 EPHA7 FRK FRK ABI1 ABI1 NRP2 NRP2 ENSMODP00000048038 ENSMODP00000048038 EPHA10 EPHA10 LCK LCK EPHA6 EPHA6 EPHA3 EPHA3 SRMS SRMS PTK6 PTK6 NTRK1 NTRK1 EPHB2 EPHB2 EPHA8 EPHA8 PTK2B PTK2B DDR1 DDR1 CAV1 CAV1 MET MET ERBB4 ERBB4 ALK ALK JAK2 JAK2 STK16 STK16 INSR INSR CLK1 CLK1 MAP2K7 MAP2K7 IL5 IL5 BAZ1B BAZ1B WEE2 WEE2 NOD2 NOD2 RSRC2 RSRC2 LRRK1 LRRK1 BLK BLK BTK BTK TIE1 TIE1 HTR2A HTR2A PRKCD PRKCD FGFR1 FGFR1 HIPK3 HIPK3 CSF1R CSF1R TYRO3 TYRO3 LTK LTK SRC SRC PKDCC PKDCC PTPN4 PTPN4 MATK MATK HIPK1 HIPK1 F6WLE6_MONDO F6WLE6_MONDO PIBF1 PIBF1 F7BHT6_MONDO F7BHT6_MONDO EPHB6 EPHB6 DDR2 DDR2 RET RET JAK1 JAK1 EPHA1 EPHA1 DYRK3 DYRK3 TESK2 TESK2 EPHA2 EPHA2 ZAP70 ZAP70 CLK4 CLK4 TEK TEK FGFRL1 FGFRL1 EPHB4 EPHB4 TYK2 TYK2 ABL2 ABL2 NRP1 NRP1 HIPK4 HIPK4 RIPK2 RIPK2 ITK ITK FGFR2 FGFR2 PTPN9 PTPN9 EGFR EGFR FLT1 FLT1 LIF LIF LOC100029431 LOC100029431 CSK CSK F7FZE2_MONDO F7FZE2_MONDO MAP2K5 MAP2K5 PDGFB PDGFB MAP2K1 MAP2K1 PDGFRB PDGFRB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1337 aa)
ENSMODP00000045874Tyrosine-protein kinase. (491 aa)
EFEMP1EGF containing fibulin extracellular matrix protein 1. (464 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
INSRRTyrosine-protein kinase receptor. (1307 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (765 aa)
DSTYKDual serine/threonine and tyrosine protein kinase. (903 aa)
FGFR4Fibroblast growth factor receptor. (849 aa)
DYRK1ADual specificity tyrosine phosphorylation regulated kinase 1A. (754 aa)
ENSMODP00000042930Eph LBD domain-containing protein. (284 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (183 aa)
ENSMODP00000041354Kazal-like domain-containing protein. (79 aa)
LOC103105989Kazal-like domain-containing protein. (89 aa)
STYK1Serine/threonine/tyrosine kinase 1. (359 aa)
MELKNon-specific serine/threonine protein kinase. (608 aa)
TTKTTK protein kinase. (895 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (967 aa)
NTRK2Tyrosine-protein kinase receptor. (750 aa)
NTRK3Tyrosine-protein kinase receptor. (850 aa)
CLK2Protein kinase domain-containing protein. (269 aa)
JAK3Tyrosine-protein kinase. (1097 aa)
AXLAXL receptor tyrosine kinase. (886 aa)
EIF2AK2Uncharacterized protein. (651 aa)
YES1Tyrosine-protein kinase. (541 aa)
EPHA4EPH receptor A4. (986 aa)
LOC100017469Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1570 aa)
EPHA5EPH receptor A5. (1050 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1343 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
FYNTyrosine-protein kinase. (600 aa)
TNK2Tyrosine kinase non receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1121 aa)
ERBB2Receptor protein-tyrosine kinase. (1257 aa)
FGFR3Fibroblast growth factor receptor. (729 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (142 aa)
WEE1WEE1 G2 checkpoint kinase. (648 aa)
ENSMODP00000052651Eph LBD domain-containing protein. (304 aa)
PTK2Uncharacterized protein. (161 aa)
MUSKMuscle associated receptor tyrosine kinase. (888 aa)
SYKTyrosine-protein kinase. (588 aa)
RELNReelin. (3458 aa)
SIRT6Uncharacterized protein. (547 aa)
ENSMODP00000055672Uncharacterized protein. (151 aa)
ENSMODP00000056005Sema domain-containing protein. (996 aa)
ENSMODP00000056551Uncharacterized protein. (292 aa)
LYNTyrosine-protein kinase. (516 aa)
CNTFCiliary neurotrophic factor. (201 aa)
DYRK1BDual specificity tyrosine phosphorylation regulated kinase 1B. (728 aa)
MERTKMER proto-oncogene, tyrosine kinase. (973 aa)
ENSMODP00000058991Fibronectin type-III domain-containing protein. (165 aa)
IGF1RTyrosine-protein kinase receptor. (1259 aa)
ENSMODP00000059161FERM domain-containing protein. (121 aa)
BMXTyrosine-protein kinase. (682 aa)
EPHB3Uncharacterized protein. (538 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1349 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1085 aa)
TECTyrosine-protein kinase. (648 aa)
TXKTyrosine-protein kinase. (525 aa)
HCKTyrosine-protein kinase. (538 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (943 aa)
PDGFRLPlatelet derived growth factor receptor like. (384 aa)
TTBK1Protein kinase domain-containing protein. (656 aa)
F7C7H2_MONDOInterleukin; Belongs to the IL-15/IL-21 family. (158 aa)
HPXHemopexin. (444 aa)
EPHB1EPH receptor B1. (545 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
EPHA7EPH receptor A7. (998 aa)
FRKTyrosine-protein kinase. (517 aa)
ABI1Abl interactor 1. (508 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (931 aa)
ENSMODP00000048038Protein kinase domain-containing protein. (68 aa)
EPHA10Eph LBD domain-containing protein. (313 aa)
LCKTyrosine-protein kinase. (686 aa)
EPHA6Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (454 aa)
EPHA3EPH receptor A3. (984 aa)
SRMSTyrosine-protein kinase. (514 aa)
PTK6Tyrosine-protein kinase. (453 aa)
NTRK1Tyrosine-protein kinase receptor. (739 aa)
EPHB2EPH receptor B2. (962 aa)
EPHA8EPH receptor A8. (1003 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (984 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (911 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1387 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
ALKTyrosine-protein kinase receptor. (548 aa)
JAK2Tyrosine-protein kinase. (1130 aa)
STK16Serine/threonine kinase 16. (305 aa)
INSRTyrosine-protein kinase receptor. (1378 aa)
CLK1CDC like kinase 1; Belongs to the protein kinase superfamily. (487 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (546 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (137 aa)
BAZ1BBromodomain adjacent to zinc finger domain 1B. (1485 aa)
WEE2Protein kinase domain-containing protein. (705 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1012 aa)
RSRC2Arginine and serine rich coiled-coil 2. (424 aa)
LRRK1Leucine rich repeat kinase 1. (2005 aa)
BLKTyrosine-protein kinase. (501 aa)
BTKTyrosine-protein kinase. (655 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa)
HTR2A5-hydroxytryptamine receptor 2A. (469 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (677 aa)
FGFR1Fibroblast growth factor receptor. (809 aa)
HIPK3Homeodomain interacting protein kinase 3. (1247 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (959 aa)
TYRO3TYRO3 protein tyrosine kinase. (820 aa)
LTKTyrosine-protein kinase receptor. (952 aa)
SRCTyrosine-protein kinase. (550 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (490 aa)
PTPN4Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (922 aa)
MATKTyrosine-protein kinase. (470 aa)
HIPK1Homeodomain interacting protein kinase 1. (1211 aa)
F6WLE6_MONDOFocal_AT domain-containing protein. (115 aa)
PIBF1Progesterone immunomodulatory binding factor 1. (794 aa)
F7BHT6_MONDOUncharacterized protein. (807 aa)
EPHB6EPH receptor B6. (1006 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (879 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1105 aa)
JAK1Protein kinase domain-containing protein. (199 aa)
EPHA1EPH receptor A1. (980 aa)
DYRK3Dual specificity tyrosine phosphorylation regulated kinase 3. (588 aa)
TESK2Testis associated actin remodelling kinase 2. (573 aa)
EPHA2EPH receptor A2. (886 aa)
ZAP70Tyrosine-protein kinase. (619 aa)
CLK4CDC like kinase 4. (507 aa)
TEKTEK receptor tyrosine kinase. (1124 aa)
FGFRL1Fibroblast growth factor receptor like 1. (494 aa)
EPHB4EPH receptor B4. (918 aa)
TYK2Tyrosine-protein kinase. (1193 aa)
ABL2Tyrosine-protein kinase. (1169 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (922 aa)
HIPK4Homeodomain interacting protein kinase 4. (617 aa)
RIPK2Receptor interacting serine/threonine kinase 2. (540 aa)
ITKTyrosine-protein kinase. (620 aa)
FGFR2Fibroblast growth factor receptor. (839 aa)
PTPN9Protein tyrosine phosphatase non-receptor type 9. (575 aa)
EGFRReceptor protein-tyrosine kinase. (1213 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1341 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
LOC100029431Uncharacterized protein. (414 aa)
CSKTyrosine-protein kinase. (450 aa)
F7FZE2_MONDOProtein kinase domain-containing protein. (472 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (235 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
PDGFRBPlatelet derived growth factor receptor beta. (1061 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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