STRINGSTRING
PCSK6 PCSK6 NKD2 NKD2 COL2A1 COL2A1 SORT1 SORT1 IL1R2 IL1R2 IGFBPL1 IGFBPL1 ACVR2A ACVR2A EPHA2 EPHA2 ACVR1C ACVR1C FGFRL1 FGFRL1 LRRC32 LRRC32 ENG ENG TGFB3 TGFB3 LTBP2 LTBP2 F7CCQ3_MONDO F7CCQ3_MONDO NRP1 NRP1 TRIM16 TRIM16 LTBP4 LTBP4 FGFR2 FGFR2 ITGA6 ITGA6 EGFR EGFR FIBP FIBP FLT1 FLT1 PDGFB PDGFB PDGFRB PDGFRB FGFR1 FGFR1 ITGAV ITGAV COL3A1 COL3A1 KAZALD1 KAZALD1 COL1A1 COL1A1 SEC61B SEC61B WFIKKN2 WFIKKN2 TGFBR1 TGFBR1 IGFBP4 IGFBP4 SCN5A SCN5A GPC1 GPC1 IL10RA IL10RA IL1RN IL1RN IL36RN IL36RN INSR INSR TGFBR2 TGFBR2 LTBP1 LTBP1 IGFBP5 IGFBP5 IGFBP2 IGFBP2 EPHA8 EPHA8 IGFALS IGFALS RHBDF1 RHBDF1 WFIKKN1 WFIKKN1 NTRK1 NTRK1 F6WYG5_MONDO F6WYG5_MONDO S100A13 S100A13 IL6ST IL6ST API5 API5 OSMR OSMR LIFR LIFR PDGFRA PDGFRA KDR KDR IGFBP7 IGFBP7 LOC100017469 LOC100017469 GHRHR GHRHR TWSG1 TWSG1 IGF2R IGF2R RHBDF2 RHBDF2 TSKU TSKU IL6R IL6R NTRK2 NTRK2 F6SBA9_MONDO F6SBA9_MONDO NGFR NGFR K7E4W0_MONDO K7E4W0_MONDO ENSMODP00000041663 ENSMODP00000041663 GLG1 GLG1 FGFR4 FGFR4 THBS1 THBS1 ACVR1 ACVR1 ENSMODP00000045040 ENSMODP00000045040 ACVR2B ACVR2B FLT4 FLT4 SRPX2 SRPX2 NRROS NRROS FLT3 FLT3 CXCL13 CXCL13 FGFR3 FGFR3 ENSMODP00000052695 ENSMODP00000052695 LTBP3 LTBP3 CEP57 CEP57 SDCBP SDCBP IGF1R IGF1R
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PCSK6Proprotein convertase subtilisin/kexin type 6; Belongs to the peptidase S8 family. (970 aa)
NKD2NKD inhibitor of WNT signaling pathway 2. (451 aa)
COL2A1Collagen type II alpha 1 chain. (886 aa)
SORT1Sortilin. (693 aa)
IL1R2Uncharacterized protein. (414 aa)
IGFBPL1Insulin like growth factor binding protein like 1. (292 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
EPHA2EPH receptor A2. (886 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (495 aa)
FGFRL1Fibroblast growth factor receptor like 1. (494 aa)
LRRC32Leucine rich repeat containing 32. (670 aa)
ENGZP domain-containing protein. (654 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1757 aa)
F7CCQ3_MONDOUncharacterized protein. (294 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (922 aa)
TRIM16Uncharacterized protein. (553 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1488 aa)
FGFR2Fibroblast growth factor receptor. (839 aa)
ITGA6Integrin subunit alpha 6; Belongs to the integrin alpha chain family. (1075 aa)
EGFRReceptor protein-tyrosine kinase. (1213 aa)
FIBPFGF1 intracellular binding protein. (358 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1341 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (235 aa)
PDGFRBPlatelet derived growth factor receptor beta. (1061 aa)
FGFR1Fibroblast growth factor receptor. (809 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1058 aa)
COL3A1Collagen type III alpha 1 chain. (1461 aa)
KAZALD1Kazal type serine peptidase inhibitor domain 1. (300 aa)
COL1A1Collagen type I alpha 1 chain. (1430 aa)
SEC61BProtein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (96 aa)
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (567 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (552 aa)
IGFBP4Insulin like growth factor binding protein 4. (260 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1839 aa)
GPC1Glypican 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (550 aa)
IL10RAFibronectin type-III domain-containing protein. (605 aa)
IL1RNInterleukin-1. (174 aa)
IL36RNInterleukin-1. (143 aa)
INSRTyrosine-protein kinase receptor. (1378 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (564 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1744 aa)
IGFBP5Uncharacterized protein. (310 aa)
IGFBP2Insulin like growth factor binding protein 2. (319 aa)
EPHA8EPH receptor A8. (1003 aa)
IGFALSInsulin like growth factor binding protein acid labile subunit. (689 aa)
RHBDF1Rhomboid 5 homolog 1. (857 aa)
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1. (553 aa)
NTRK1Tyrosine-protein kinase receptor. (739 aa)
F6WYG5_MONDOHCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (231 aa)
S100A13S100 calcium binding protein A13; Belongs to the S-100 family. (98 aa)
IL6STInterleukin 6 signal transducer. (923 aa)
API5Apoptosis inhibitor 5. (501 aa)
OSMRUncharacterized protein. (908 aa)
LIFRLIF receptor subunit alpha. (1101 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1085 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1349 aa)
IGFBP7Insulin like growth factor binding protein 7. (287 aa)
LOC100017469Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1570 aa)
GHRHRUncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (700 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (222 aa)
IGF2RInsulin like growth factor 2 receptor. (2520 aa)
RHBDF2Rhomboid 5 homolog 2. (830 aa)
TSKUTsukushi, small leucine rich proteoglycan. (353 aa)
IL6RInterleukin-6 receptor alpha. (467 aa)
NTRK2Tyrosine-protein kinase receptor. (750 aa)
F6SBA9_MONDOThyroglobulin type-1 domain-containing protein. (77 aa)
NGFRNerve growth factor receptor. (433 aa)
K7E4W0_MONDOFibronectin type-III domain-containing protein. (529 aa)
ENSMODP00000041663Uncharacterized protein. (668 aa)
GLG1Golgi glycoprotein 1. (1237 aa)
FGFR4Fibroblast growth factor receptor. (849 aa)
THBS1Thrombospondin 1. (1197 aa)
ACVR1TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (559 aa)
ENSMODP00000045040Uncharacterized protein. (1025 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (530 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1337 aa)
SRPX2Sushi repeat containing protein X-linked 2. (484 aa)
NRROSNegative regulator of reactive oxygen species. (782 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (976 aa)
CXCL13SCY domain-containing protein. (111 aa)
FGFR3Fibroblast growth factor receptor. (729 aa)
ENSMODP00000052695Uncharacterized protein. (143 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1267 aa)
CEP57Centrosomal protein 57. (493 aa)
SDCBPSyndecan binding protein. (311 aa)
IGF1RTyrosine-protein kinase receptor. (1259 aa)
Your Current Organism:
Monodelphis domestica
NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum
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