53 items (Monodelphis domestica) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BBS1	BBS1 domain-containing protein. (559 aa)
	LRP8	LDL receptor related protein 8. (854 aa)
	ATP2B4	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1058 aa)
	PHLPP2	PH domain and leucine rich repeat protein phosphatase 2. (1349 aa)
	GLI3	GLI family zinc finger 3. (1501 aa)
	FEZF2	FEZ family zinc finger 2. (487 aa)
	PROX1	Prospero homeobox 1. (782 aa)
	FEZ1	Fasciculation and elongation protein zeta 1. (408 aa)
	MKKS	McKusick-Kaufman syndrome. (570 aa)
	LOC100012668	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (377 aa)
	F7G4H7_MONDO	FERM domain-containing protein. (482 aa)
	MAS1	MAS1 proto-oncogene, G protein-coupled receptor; Belongs to the G-protein coupled receptor 1 family. (325 aa)
	DLX1	Distal-less homeobox 1. (255 aa)
	DLX2	Distal-less homeobox 2. (329 aa)
	EMX2	Empty spiracles homeobox 2. (248 aa)
	YWHAE	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family. (251 aa)
	CRK	CRK proto-oncogene, adaptor protein. (297 aa)
	TSC1	TSC complex subunit 1. (1152 aa)
	KIF14	Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1710 aa)
	BBS2	Bardet-Biedl syndrome 2 protein homolog. (722 aa)
	LOC100015788	Uncharacterized protein. (82 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (785 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (450 aa)
	CRKL	Uncharacterized protein. (303 aa)
	MFSD2A	Major facilitator superfamily domain containing 2A. (504 aa)
	HDAC2	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1. (385 aa)
	SRF	Serum response factor. (490 aa)
	LEF1	Lymphoid enhancer binding factor 1. (401 aa)
	UBA6	Ubiquitin like modifier activating enzyme 6. (1009 aa)
	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (409 aa)
	CDK5R1	Cyclin-dependent kinase 5 activator. (306 aa)
	ATAT1	Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...] (470 aa)
	TSKU	Tsukushi, small leucine rich proteoglycan. (353 aa)
	NEUROD6	Neurogenic differentiation factor. (337 aa)
	BCAN	Brevican. (885 aa)
	TENT2	Terminal nucleotidyltransferase 2. (499 aa)
	ENSMODP00000041618	Uncharacterized protein. (93 aa)
	DCLK2	Uncharacterized protein. (1631 aa)
	TMEM108	Uncharacterized protein. (105 aa)
	FAM205A	Uncharacterized protein. (1362 aa)
	BTG2	Uncharacterized protein. (162 aa)
	BBS4	Bardet-Biedl syndrome 4. (621 aa)
	ENSMODP00000053169	Uncharacterized protein. (59 aa)
	NF2	Neurofibromin 2. (595 aa)
	FGF13	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (249 aa)
	RELN	Reelin. (3458 aa)
	CDK5R2	Cyclin-dependent kinase 5 activator. (361 aa)
	ENSMODP00000057195	SH2 domain-containing protein. (119 aa)
	CDK5	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1259 aa)
	ANXA3	Annexin. (345 aa)
	KIRREL3	Kirre like nephrin family adhesion molecule 3. (778 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BBS1	BBS2	ENSMODP00000010171	ENSMODP00000016740	BBS1 domain-containing protein.	Bardet-Biedl syndrome 2 protein homolog.	0.995
BBS1	BBS4	ENSMODP00000010171	ENSMODP00000051495	BBS1 domain-containing protein.	Bardet-Biedl syndrome 4.	0.995
BBS1	MKKS	ENSMODP00000010171	ENSMODP00000005982	BBS1 domain-containing protein.	McKusick-Kaufman syndrome.	0.437
BBS1	SMO	ENSMODP00000010171	ENSMODP00000018347	BBS1 domain-containing protein.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.772
BBS2	BBS1	ENSMODP00000016740	ENSMODP00000010171	Bardet-Biedl syndrome 2 protein homolog.	BBS1 domain-containing protein.	0.995
BBS2	BBS4	ENSMODP00000016740	ENSMODP00000051495	Bardet-Biedl syndrome 2 protein homolog.	Bardet-Biedl syndrome 4.	0.994
BBS2	MKKS	ENSMODP00000016740	ENSMODP00000005982	Bardet-Biedl syndrome 2 protein homolog.	McKusick-Kaufman syndrome.	0.427
BBS2	SMO	ENSMODP00000016740	ENSMODP00000018347	Bardet-Biedl syndrome 2 protein homolog.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.650
BBS4	BBS1	ENSMODP00000051495	ENSMODP00000010171	Bardet-Biedl syndrome 4.	BBS1 domain-containing protein.	0.995
BBS4	BBS2	ENSMODP00000051495	ENSMODP00000016740	Bardet-Biedl syndrome 4.	Bardet-Biedl syndrome 2 protein homolog.	0.994
BBS4	SMO	ENSMODP00000051495	ENSMODP00000018347	Bardet-Biedl syndrome 4.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.638
CDK5	CDK5R1	ENSMODP00000057999	ENSMODP00000028842	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily.	Cyclin-dependent kinase 5 activator.	0.995
CDK5	CDK5R2	ENSMODP00000057999	ENSMODP00000055949	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily.	Cyclin-dependent kinase 5 activator.	0.959
CDK5R1	CDK5	ENSMODP00000028842	ENSMODP00000057999	Cyclin-dependent kinase 5 activator.	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily.	0.995
CDK5R1	PAFAH1B1	ENSMODP00000028842	ENSMODP00000028692	Cyclin-dependent kinase 5 activator.	Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...]	0.403
CDK5R2	CDK5	ENSMODP00000055949	ENSMODP00000057999	Cyclin-dependent kinase 5 activator.	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily.	0.959
CDK5R2	PAFAH1B1	ENSMODP00000055949	ENSMODP00000028692	Cyclin-dependent kinase 5 activator.	Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...]	0.403
CRK	CRKL	ENSMODP00000012751	ENSMODP00000021994	CRK proto-oncogene, adaptor protein.	Uncharacterized protein.	0.536
CRK	ENSMODP00000057195	ENSMODP00000012751	ENSMODP00000057195	CRK proto-oncogene, adaptor protein.	SH2 domain-containing protein.	0.536
CRK	YWHAE	ENSMODP00000012751	ENSMODP00000012735	CRK proto-oncogene, adaptor protein.	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; Belongs to the 14-3-3 family.	0.430