(74 nodes) Metencephalon development network (Monodelphis domestica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	ARCN1	Coatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (511 aa)
	LOC100015788	Uncharacterized protein. (82 aa)
	DIXDC1	DIX domain containing 1. (681 aa)
	AARS1	Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (968 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (785 aa)
	SLC25A46	Solute carrier family 25 member 46; Belongs to the mitochondrial carrier (TC 2.A.29) family. (417 aa)
	F7ASC3_MONDO	Uncharacterized protein. (274 aa)
	CRKL	Uncharacterized protein. (303 aa)
	RERE	Arginine-glutamic acid dipeptide repeats. (1561 aa)
	CRK	CRK proto-oncogene, adaptor protein. (297 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (335 aa)
	RPGRIP1L	RPGRIP1 like. (1268 aa)
	SERPINE2	Serpin family E member 2; Belongs to the serpin family. (469 aa)
	ENSMODP00000055901	Uncharacterized protein. (350 aa)
	CDK5R2	Cyclin-dependent kinase 5 activator. (361 aa)
	OPHN1	Oligophrenin 1. (633 aa)
	ENSMODP00000057195	SH2 domain-containing protein. (119 aa)
	LRRC1	Leucine rich repeat containing 1. (503 aa)
	CDK5	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	ENSMODP00000059044	SH2 domain-containing protein. (79 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1259 aa)
	NAGLU	Uncharacterized protein. (518 aa)
	TTBK2	Tau tubulin kinase 2. (1259 aa)
	KLHL1	Kelch like family member 1. (749 aa)
	F6YRI3_MONDO	Uncharacterized protein. (647 aa)
	GDF10	Growth differentiation factor 10. (493 aa)
	B4GALT2	Beta-1,4-galactosyltransferase 2. (356 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (599 aa)
	PROX1	Prospero homeobox 1. (782 aa)
	GAS1	Growth arrest specific 1. (373 aa)
	LHX5	Homeobox domain-containing protein. (211 aa)
	FZD4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (540 aa)
	PTBP2	Polypyrimidine tract binding protein 2. (531 aa)
	FAIM2	Fas apoptotic inhibitory molecule 2; Belongs to the BI1 family. (316 aa)
	EN1	Homeobox protein engrailed-like. (434 aa)
	BCL2	BCL2 apoptosis regulator. (188 aa)
	CDK5R1	Cyclin-dependent kinase 5 activator. (306 aa)
	SEMA4C	Uncharacterized protein; Belongs to the semaphorin family. (832 aa)
	WHRN	Whirlin. (970 aa)
	HSPA5	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (657 aa)
	CLP1-2	Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; thi [...] (433 aa)
	KLHL5	Kelch like family member 5. (708 aa)
	KLHL4	Kelch like family member 4. (606 aa)
	PDSS2	Decaprenyl diphosphate synthase subunit 2; Belongs to the FPP/GGPP synthase family. (399 aa)
	SEZ6L2	Seizure related 6 homolog like 2. (920 aa)
	TTC21B	Tetratricopeptide repeat domain 21B. (1315 aa)
	GBX2	Gastrulation brain homeobox 2. (352 aa)
	PHOX2A	Paired like homeobox 2A. (282 aa)
	COQ8B	Coenzyme Q8B. (530 aa)
	F6ZYR7_MONDO	Uncharacterized protein. (699 aa)
	AGTPBP1	ATP/GTP binding protein 1. (1163 aa)
	PTF1A	Pancreas associated transcription factor 1a. (335 aa)
	SCRIB	Scribble planar cell polarity protein. (1599 aa)
	NANOS1	Nanos C2HC-type zinc finger 1; Belongs to the nanos family. (290 aa)
	GNPAT	Dihydroxyacetone phosphate acyltransferase. (686 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (734 aa)
	SEC24B	SEC24 homolog B, COPII coat complex component. (1099 aa)
	HOXB1	Homeobox domain-containing protein. (298 aa)
	FAM205A	Uncharacterized protein. (1362 aa)
	RORA	RAR related orphan receptor A. (523 aa)
	NCSTN	Nicastrin. (790 aa)
	ENSMODP00000042313	Uncharacterized protein. (84 aa)
	OTX1	Orthodenticle homeobox 1. (367 aa)
	ENSMODP00000041618	Uncharacterized protein. (93 aa)
	TTLL1	Tubulin tyrosine ligase like 1. (424 aa)
	K7E0A4_MONDO	Uncharacterized protein. (667 aa)
	KCNE1	Uncharacterized protein. (126 aa)
	EZH2	Uncharacterized protein. (665 aa)
	CLP1	Cleavage and polyadenylation factor I subunit 1. (425 aa)
	LDB1	LIM domain binding 1. (411 aa)
	MECP2	Methyl-CpG binding protein 2. (537 aa)
	CNTN1	Contactin 1. (1007 aa)
	KIF14	Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1710 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARCN1	SEC24B	ENSMODP00000016800	ENSMODP00000049174	Coatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.	SEC24 homolog B, COPII coat complex component.	0.617
BCL2	HSPA5	ENSMODP00000006458	ENSMODP00000024667	BCL2 apoptosis regulator.	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	0.459
BCL2	IGF1R	ENSMODP00000006458	ENSMODP00000059069	BCL2 apoptosis regulator.	Tyrosine-protein kinase receptor.	0.413
CDK5	CDK5R1	ENSMODP00000057999	ENSMODP00000028842	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily.	Cyclin-dependent kinase 5 activator.	0.995
CDK5	CDK5R2	ENSMODP00000057999	ENSMODP00000055949	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily.	Cyclin-dependent kinase 5 activator.	0.959
CDK5	NCSTN	ENSMODP00000057999	ENSMODP00000043878	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily.	Nicastrin.	0.405
CDK5R1	CDK5	ENSMODP00000028842	ENSMODP00000057999	Cyclin-dependent kinase 5 activator.	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily.	0.995
CDK5R2	CDK5	ENSMODP00000055949	ENSMODP00000057999	Cyclin-dependent kinase 5 activator.	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily.	0.959
COQ8B	PDSS2	ENSMODP00000009810	ENSMODP00000022466	Coenzyme Q8B.	Decaprenyl diphosphate synthase subunit 2; Belongs to the FPP/GGPP synthase family.	0.467
CRK	CRKL	ENSMODP00000012751	ENSMODP00000021994	CRK proto-oncogene, adaptor protein.	Uncharacterized protein.	0.536
CRK	ENSMODP00000057195	ENSMODP00000012751	ENSMODP00000057195	CRK proto-oncogene, adaptor protein.	SH2 domain-containing protein.	0.536
CRKL	CRK	ENSMODP00000021994	ENSMODP00000012751	Uncharacterized protein.	CRK proto-oncogene, adaptor protein.	0.536
CRKL	IGF1R	ENSMODP00000021994	ENSMODP00000059069	Uncharacterized protein.	Tyrosine-protein kinase receptor.	0.934
DLL1	MECP2	ENSMODP00000049507	ENSMODP00000014588	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Methyl-CpG binding protein 2.	0.456
EN1	WNT1	ENSMODP00000006131	ENSMODP00000052765	Homeobox protein engrailed-like.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.465
ENSMODP00000042313	EZH2	ENSMODP00000042313	ENSMODP00000033725	Uncharacterized protein.	Uncharacterized protein.	0.816
ENSMODP00000057195	CRK	ENSMODP00000057195	ENSMODP00000012751	SH2 domain-containing protein.	CRK proto-oncogene, adaptor protein.	0.536
ENSMODP00000059044	IGF1R	ENSMODP00000059044	ENSMODP00000059069	SH2 domain-containing protein.	Tyrosine-protein kinase receptor.	0.487
EZH2	ENSMODP00000042313	ENSMODP00000033725	ENSMODP00000042313	Uncharacterized protein.	Uncharacterized protein.	0.816
F6YRI3_MONDO	K7E0A4_MONDO	ENSMODP00000001250	ENSMODP00000039205	Uncharacterized protein.	Uncharacterized protein.	0.543