(17 nodes) Macrophage differentiation network (Monodelphis domestica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CASP18	Uncharacterized protein; Belongs to the peptidase C14A family. (471 aa)
	CEBPE	CCAAT/enhancer-binding protein. (278 aa)
	TSPAN2	Tetraspanin. (219 aa)
	EIF2AK1	Eukaryotic translation initiation factor 2 alpha kinase 1. (630 aa)
	GAB3	GRB2 associated binding protein 3. (564 aa)
	CEBPA	CCAAT enhancer binding protein alpha. (358 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (472 aa)
	SIRT1	Deacetylase sirtuin-type domain-containing protein. (713 aa)
	VEGFA	Vascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (445 aa)
	CSF1	Uncharacterized protein. (340 aa)
	CD4	CD4. (461 aa)
	LOC100016987	Uncharacterized protein; Belongs to the peptidase C14A family. (472 aa)
	IL15	Interleukin; Belongs to the IL-15/IL-21 family. (183 aa)
	APP	Amyloid beta precursor protein. (717 aa)
	NRROS	Negative regulator of reactive oxygen species. (782 aa)
	ZBTB46	Zinc finger and BTB domain containing 46. (666 aa)
	NKX2-3	NK2 homeobox 3. (345 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP18	CASP8	ENSMODP00000040167	ENSMODP00000018969	Uncharacterized protein; Belongs to the peptidase C14A family.	Caspase 8; Belongs to the peptidase C14A family.	0.910
CASP18	CD4	ENSMODP00000040167	ENSMODP00000035778	Uncharacterized protein; Belongs to the peptidase C14A family.	CD4.	0.417
CASP18	LOC100016987	ENSMODP00000040167	ENSMODP00000036251	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.913
CASP8	CASP18	ENSMODP00000018969	ENSMODP00000040167	Caspase 8; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.910
CASP8	CD4	ENSMODP00000018969	ENSMODP00000035778	Caspase 8; Belongs to the peptidase C14A family.	CD4.	0.417
CASP8	LOC100016987	ENSMODP00000018969	ENSMODP00000036251	Caspase 8; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.907
CD4	CASP18	ENSMODP00000035778	ENSMODP00000040167	CD4.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.417
CD4	CASP8	ENSMODP00000035778	ENSMODP00000018969	CD4.	Caspase 8; Belongs to the peptidase C14A family.	0.417
CD4	CSF1	ENSMODP00000035778	ENSMODP00000029060	CD4.	Uncharacterized protein.	0.731
CD4	IL15	ENSMODP00000035778	ENSMODP00000042052	CD4.	Interleukin; Belongs to the IL-15/IL-21 family.	0.739
CD4	LOC100016987	ENSMODP00000035778	ENSMODP00000036251	CD4.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.417
CD4	ZBTB46	ENSMODP00000035778	ENSMODP00000048978	CD4.	Zinc finger and BTB domain containing 46.	0.406
CSF1	CD4	ENSMODP00000029060	ENSMODP00000035778	Uncharacterized protein.	CD4.	0.731
IL15	CD4	ENSMODP00000042052	ENSMODP00000035778	Interleukin; Belongs to the IL-15/IL-21 family.	CD4.	0.739
LOC100016987	CASP18	ENSMODP00000036251	ENSMODP00000040167	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.913
LOC100016987	CASP8	ENSMODP00000036251	ENSMODP00000018969	Uncharacterized protein; Belongs to the peptidase C14A family.	Caspase 8; Belongs to the peptidase C14A family.	0.907
LOC100016987	CD4	ENSMODP00000036251	ENSMODP00000035778	Uncharacterized protein; Belongs to the peptidase C14A family.	CD4.	0.417
ZBTB46	CD4	ENSMODP00000048978	ENSMODP00000035778	Zinc finger and BTB domain containing 46.	CD4.	0.406