(39 nodes) Osteoclast differentiation network (Monodelphis domestica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SH3PXD2A	SH3 and PX domains 2A. (1133 aa)
	EFNA2	Ephrin A2; Belongs to the ephrin family. (200 aa)
	WISP1	IGFBP N-terminal domain-containing protein. (172 aa)
	CSF1	Uncharacterized protein. (340 aa)
	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (409 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (540 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (731 aa)
	H9H7E3_MONDO	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (459 aa)
	TFRC	Transferrin receptor. (771 aa)
	OSTM1	Osteoclastogenesis associated transmembrane protein 1. (338 aa)
	FARP2	FERM, ARH/RhoGEF and pleckstrin domain protein 2. (940 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (229 aa)
	GPC3	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (486 aa)
	TNFSF11	Tumor necrosis factor ligand superfamily member. (317 aa)
	GLO1	Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (184 aa)
	TCTA	T-cell leukemia translocation-altered gene protein homolog; May be required for cellular fusion during osteoclastogenesis; Belongs to the TCTA family. (109 aa)
	LRRK1	Leucine rich repeat kinase 1. (2005 aa)
	IREB2	Aconitase domain-containing protein. (282 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	CSF1R	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (959 aa)
	ATP6AP1	Uncharacterized protein. (491 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (424 aa)
	FAM20C	FAM20C golgi associated secretory pathway kinase. (591 aa)
	GPR183	G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (355 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (379 aa)
	DCSTAMP	Dendrocyte expressed seven transmembrane protein. (447 aa)
	TNFRSF11A	TNFR-Cys domain-containing protein. (670 aa)
	EPHA2	EPH receptor A2. (886 aa)
	SNX10	Sorting nexin 10. (306 aa)
	GPR68	G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (344 aa)
	CREB1	cAMP responsive element binding protein 1. (327 aa)
	ENSMODP00000058674	Uncharacterized protein. (456 aa)
	TCIRG1	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (559 aa)
	NF1	Neurofibromin 1. (2781 aa)
	JUNB	JunB proto-oncogene, AP-1 transcription factor subunit. (357 aa)
	SBNO2	Strawberry notch homolog 2. (1400 aa)
	ENSMODP00000051863	Uncharacterized protein. (461 aa)
	TMEM64	Transmembrane protein 64. (389 aa)
	FOXP1	Fork-head domain-containing protein. (693 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP6AP1	TCIRG1	ENSMODP00000011047	ENSMODP00000057638	Uncharacterized protein.	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.	0.969
CREB1	CTNNB1	ENSMODP00000059251	ENSMODP00000014004	cAMP responsive element binding protein 1.	Catenin beta 1.	0.676
CREB1	FOS	ENSMODP00000059251	ENSMODP00000007329	cAMP responsive element binding protein 1.	Fos proto-oncogene, AP-1 transcription factor subunit.	0.767
CREB1	JUNB	ENSMODP00000059251	ENSMODP00000053073	cAMP responsive element binding protein 1.	JunB proto-oncogene, AP-1 transcription factor subunit.	0.454
CREB1	PIK3R1	ENSMODP00000059251	ENSMODP00000024566	cAMP responsive element binding protein 1.	Phosphoinositide-3-kinase regulatory subunit 1.	0.586
CREB1	TNF	ENSMODP00000059251	ENSMODP00000019686	cAMP responsive element binding protein 1.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.449
CSF1	CSF1R	ENSMODP00000029060	ENSMODP00000012194	Uncharacterized protein.	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.999
CSF1	FAM20C	ENSMODP00000029060	ENSMODP00000010565	Uncharacterized protein.	FAM20C golgi associated secretory pathway kinase.	0.551
CSF1	TGFB1	ENSMODP00000029060	ENSMODP00000010737	Uncharacterized protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.452
CSF1	TNF	ENSMODP00000029060	ENSMODP00000019686	Uncharacterized protein.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.484
CSF1	TNFSF11	ENSMODP00000029060	ENSMODP00000018584	Uncharacterized protein.	Tumor necrosis factor ligand superfamily member.	0.596
CSF1R	CSF1	ENSMODP00000012194	ENSMODP00000029060	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Uncharacterized protein.	0.999
CSF1R	EFNA2	ENSMODP00000012194	ENSMODP00000041802	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Ephrin A2; Belongs to the ephrin family.	0.660
CSF1R	PIK3R1	ENSMODP00000012194	ENSMODP00000024566	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Phosphoinositide-3-kinase regulatory subunit 1.	0.758
CSF1R	TNFSF11	ENSMODP00000012194	ENSMODP00000018584	Colony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Tumor necrosis factor ligand superfamily member.	0.716
CTNNB1	CREB1	ENSMODP00000014004	ENSMODP00000059251	Catenin beta 1.	cAMP responsive element binding protein 1.	0.676
CTNNB1	EPHA2	ENSMODP00000014004	ENSMODP00000004043	Catenin beta 1.	EPH receptor A2.	0.410
CTNNB1	PIK3R1	ENSMODP00000014004	ENSMODP00000024566	Catenin beta 1.	Phosphoinositide-3-kinase regulatory subunit 1.	0.488
CTNNB1	TGFB1	ENSMODP00000014004	ENSMODP00000010737	Catenin beta 1.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.542
CTNNB1	TNF	ENSMODP00000014004	ENSMODP00000019686	Catenin beta 1.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.405