(41 nodes) Positive regulation of epithelial cell differentiation network (Monodelphis domestica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MACROH2A1	H2A histone family member Y. (406 aa)
	ZBED3	BED-type domain-containing protein. (234 aa)
	PAX6	Paired box 6. (221 aa)
	TMEM100	Transmembrane protein 100. (114 aa)
	SFN	Stratifin; Belongs to the 14-3-3 family. (256 aa)
	CYP27B1	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (516 aa)
	GDNF	Glial cell derived neurotrophic factor. (183 aa)
	BMP6	Bone morphogenetic protein 6. (534 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	SFRP4	Secreted frizzled related protein 4. (348 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1609 aa)
	BMP4	Bone morphogenetic protein 4. (410 aa)
	KDF1	Keratinocyte differentiation factor 1. (415 aa)
	ETV4	ETS variant 4. (478 aa)
	RFX3	Regulatory factor X3. (753 aa)
	NCOA3	Nuclear receptor coactivator. (1400 aa)
	LOC100030262	Anti_prolifrtn domain-containing protein. (151 aa)
	CYP27C1	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (372 aa)
	FGF2	Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (156 aa)
	FOXN1	Forkhead box N1. (636 aa)
	ATOH1	Atonal bHLH transcription factor 1. (380 aa)
	LOC100015455	BHLH domain-containing protein. (262 aa)
	LOC100013657	Uncharacterized protein. (332 aa)
	ENSMODP00000054835	Uncharacterized protein. (83 aa)
	AHI1	Abelson helper integration site 1. (1237 aa)
	PROM1	Prominin 1. (875 aa)
	ATOH8	BHLH domain-containing protein. (328 aa)
	GDF2	TGF_BETA_2 domain-containing protein. (427 aa)
	SERPINE1	Serpin family E member 1; Belongs to the serpin family. (413 aa)
	ENSMODP00000045775	SAM domain-containing protein. (300 aa)
	MACROH2A2	H2A histone family member Y2. (347 aa)
	BAD	Uncharacterized protein. (212 aa)
	ETV2	ETS domain-containing protein. (294 aa)
	VDR	Uncharacterized protein. (289 aa)
	PTCH2	Patched 2. (992 aa)
	PTCH1	Patched 1. (1521 aa)
	BMP2	Bone morphogenetic protein 2. (436 aa)
	TRIM16	Uncharacterized protein. (553 aa)
	FOXJ1	Forkhead box J1. (418 aa)
	LIF	LIF interleukin 6 family cytokine. (202 aa)
	BTG1	BTG anti-proliferation factor 1. (169 aa)

Your Current Organism:

Monodelphis domestica

NCBI taxonomy Id: 13616
Other names: gray short-tailed opossum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATOH1	PAX6	ENSMODP00000024053	ENSMODP00000034398	Atonal bHLH transcription factor 1.	Paired box 6.	0.460
BAD	SFN	ENSMODP00000044261	ENSMODP00000032232	Uncharacterized protein.	Stratifin; Belongs to the 14-3-3 family.	0.639
BMP2	BMP4	ENSMODP00000004813	ENSMODP00000016205	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.901
BMP2	BMP6	ENSMODP00000004813	ENSMODP00000012538	Bone morphogenetic protein 2.	Bone morphogenetic protein 6.	0.957
BMP2	PTCH1	ENSMODP00000004813	ENSMODP00000003369	Bone morphogenetic protein 2.	Patched 1.	0.425
BMP2	PTCH2	ENSMODP00000004813	ENSMODP00000003066	Bone morphogenetic protein 2.	Patched 2.	0.425
BMP4	BMP2	ENSMODP00000016205	ENSMODP00000004813	Bone morphogenetic protein 4.	Bone morphogenetic protein 2.	0.901
BMP4	BMP6	ENSMODP00000016205	ENSMODP00000012538	Bone morphogenetic protein 4.	Bone morphogenetic protein 6.	0.959
BMP4	PTCH1	ENSMODP00000016205	ENSMODP00000003369	Bone morphogenetic protein 4.	Patched 1.	0.425
BMP4	PTCH2	ENSMODP00000016205	ENSMODP00000003066	Bone morphogenetic protein 4.	Patched 2.	0.425
BMP6	BMP2	ENSMODP00000012538	ENSMODP00000004813	Bone morphogenetic protein 6.	Bone morphogenetic protein 2.	0.957
BMP6	BMP4	ENSMODP00000012538	ENSMODP00000016205	Bone morphogenetic protein 6.	Bone morphogenetic protein 4.	0.959
CTNNB1	FGF2	ENSMODP00000014004	ENSMODP00000023577	Catenin beta 1.	Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family.	0.403
CTNNB1	PROM1	ENSMODP00000014004	ENSMODP00000051970	Catenin beta 1.	Prominin 1.	0.511
CTNNB1	SFN	ENSMODP00000014004	ENSMODP00000032232	Catenin beta 1.	Stratifin; Belongs to the 14-3-3 family.	0.509
CTNNB1	SFRP4	ENSMODP00000014004	ENSMODP00000015758	Catenin beta 1.	Secreted frizzled related protein 4.	0.473
CYP27B1	MED1	ENSMODP00000026680	ENSMODP00000015961	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.561
CYP27B1	VDR	ENSMODP00000026680	ENSMODP00000039221	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.441
CYP27C1	MED1	ENSMODP00000023310	ENSMODP00000015961	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.561
CYP27C1	VDR	ENSMODP00000023310	ENSMODP00000039221	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.441